TY - JOUR
T1 - The emerging field of transport engineering of plant specialized metabolites
AU - Nour-Eldin, Hussam Hassan
AU - Halkier, Barbara Ann
N1 - Special issue: Food biotechnology • Plant biotechnology
PY - 2013/4
Y1 - 2013/4
N2 - From a biotechnological perspective transport processes represent attractive targets for modulation of metabolite levels and are the foundation for the emerging field of transport engineering. Potential applications of transport engineering include control of metabolite accumulation in a tissue-specific manner in crop plants as well as increased yields of commercially valuable compounds produced in synthetic biology approaches. Within specialized metabolism, recent advances include identification of not only vacuolar but now also plasma membrane-localized transporters and neo-functionalization of members of primary metabolite transporter families to include specific roles in transport of specialized metabolites. As glucosinolates are specialized metabolites of the model plant Arabidopsis, glucosinolate transport processes emerge as a model system for studying transport of specialized metabolites.
AB - From a biotechnological perspective transport processes represent attractive targets for modulation of metabolite levels and are the foundation for the emerging field of transport engineering. Potential applications of transport engineering include control of metabolite accumulation in a tissue-specific manner in crop plants as well as increased yields of commercially valuable compounds produced in synthetic biology approaches. Within specialized metabolism, recent advances include identification of not only vacuolar but now also plasma membrane-localized transporters and neo-functionalization of members of primary metabolite transporter families to include specific roles in transport of specialized metabolites. As glucosinolates are specialized metabolites of the model plant Arabidopsis, glucosinolate transport processes emerge as a model system for studying transport of specialized metabolites.
U2 - 10.1016/j.copbio.2012.09.006
DO - 10.1016/j.copbio.2012.09.006
M3 - Journal article
C2 - 23040969
SN - 0958-1669
VL - 24
SP - 263
EP - 270
JO - Current Opinion in Biotechnology
JF - Current Opinion in Biotechnology
IS - 2
ER -