The effects of impact and non-impact exercise on circulating markers of collagen remodelling in humans

TY - JOUR

T1 - The effects of impact and non-impact exercise on circulating markers of collagen remodelling in humans

AU - Mackey, Abigail

AU - Donnelly, Alan E

AU - Swanton, Alan

AU - Murray, Fiona

AU - Turpeenniemi-Hujanen, Taina

N1 - Keywords: Adult; Biological Markers; Collagen Type IV; Creatine Kinase; Epitopes; Female; Humans; Immersion; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Running; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2

PY - 2006

Y1 - 2006

N2 - Exercise has been shown to influence collagen synthesis and degradation. The aim of this study was to determine whether the stimulus for these changes is metabolic or mechanical. Eight healthy adults aged 22 +/- 4 years (mean +/- s) completed two exercise bouts-a 10 km road run and a deep water running session. Blood samples were collected before exercise and on days 1, 2, 3, 6 and 10 after exercise for measurement of creatine kinase activity, type IV collagen antigenicity, and concentrations of matrix metalloproteinase (MMP)- 9, tissue inhibitors of metalloproteinase (TIMP)- 1 and -2, and the MMP-2/TIMP-2 complex. Serum creatine kinase was elevated 24 h after the road run, but unchanged after the deep water running session. Serum collagen IV antigenicity decreased after both the road run and the deep water running session, suggesting suppressed type IV collagen synthesis in response to exercise, although serum MMPs and TIMPs remained unchanged after exercise. These results suggest that collagen IV synthesis is temporarily suppressed after exercise, irrespective of exercise type.

AB - Exercise has been shown to influence collagen synthesis and degradation. The aim of this study was to determine whether the stimulus for these changes is metabolic or mechanical. Eight healthy adults aged 22 +/- 4 years (mean +/- s) completed two exercise bouts-a 10 km road run and a deep water running session. Blood samples were collected before exercise and on days 1, 2, 3, 6 and 10 after exercise for measurement of creatine kinase activity, type IV collagen antigenicity, and concentrations of matrix metalloproteinase (MMP)- 9, tissue inhibitors of metalloproteinase (TIMP)- 1 and -2, and the MMP-2/TIMP-2 complex. Serum creatine kinase was elevated 24 h after the road run, but unchanged after the deep water running session. Serum collagen IV antigenicity decreased after both the road run and the deep water running session, suggesting suppressed type IV collagen synthesis in response to exercise, although serum MMPs and TIMPs remained unchanged after exercise. These results suggest that collagen IV synthesis is temporarily suppressed after exercise, irrespective of exercise type.

U2 - 10.1080/02640410500231470

DO - 10.1080/02640410500231470

M3 - Journal article

C2 - 16815778

SN - 0264-0414

VL - 24

SP - 843

EP - 848

JO - Journal of Sports Sciences

JF - Journal of Sports Sciences

IS - 8

ER -