Abstract
The renal clearance of endogenous creatinine (CCr), sodium (CNa) and lithium (CLi) was determined before and after a single intravenous bolus of cimetidine in nine renal transplant recipients. The glomerular filtration rate (GFR) was measured with 125I-iothalamate clearance (CTh). The initial CCr of 65 ml/min (median) was reduced to a nadir of 46 ml/min (p less than 0.01) during the first 2 h after infusion of cimetidine. GFR remained unchanged, and thus the fractional clearance of creatinine (CCr/CTh) was reduced from 1.43 (median) to 1.03 (p less than 0.01). CNa and the fractional excretion of sodium decreased throughout the study (p less than 0.05); CLi was unchanged. In conclusion cimetidine, when measured during 1-h clearance periods, interferes with tubular creatinine secretion in the denervated kidney of transplant recipients without affecting the glomerular filtration rate or proximal tubular flow. This suggests that on-going cimetidine treatment must be taken into account when graft function is evaluated by the CCr alone.
| Original language | English |
|---|---|
| Journal | Scandinavian Journal of Clinical & Laboratory Investigation |
| Volume | 49 |
| Issue number | 2 |
| Pages (from-to) | 155-9 |
| Number of pages | 5 |
| ISSN | 0036-5513 |
| Publication status | Published - Apr 1989 |
Keywords
- Absorption
- Adult
- Cimetidine
- Creatinine
- Glomerular Filtration Rate
- Humans
- Kidney Transplantation
- Kidney Tubules
- Lithium
- Male
- Metabolic Clearance Rate
- Middle Aged
- Sodium