The effect of voluntarily ingested buprenorphine on rats subjected to surgically induced global cerebral ischaemia

Otto Henrik Kalliokoski; Klas Abelson; Janne Koch; Anna Boschian; Sarah F Thormose; Natasha Fauerby; Rune Skovgaard Rasmussen; Flemming Fryd Johansen; Jann Hau

The effect of voluntarily ingested buprenorphine on rats subjected to surgically induced global cerebral ischaemia

Otto Henrik Kalliokoski, Klas Abelson, Janne Koch, Anna Boschian, Sarah F Thormose, Natasha Fauerby, Rune Skovgaard Rasmussen, Flemming Fryd Johansen, Jann Hau

26 Citations (Scopus)

Abstract

The effect of perioperatively administered buprenorphine analgesia on rats subjected to surgically induced global ischaemia was assessed. Rats supplied with buprenorphine, mixed in nut paste for voluntary ingestion, displayed significant reductions in postoperative excretions of faecal corticosterone, in both magnitude and variance. This is indicative of lowered stress levels and less inter-animal metabolic variation. Although corticosterone has been reported to modulate the extent of cerebral damage, histology of coronal sections exhibited no differences in the extent of the ischaemia in buprenorphine-treated and untreated animals. A part from a slightly higher hyperthermia immediately after surgery and typical opiate-associated behaviour, the buprenorphine treatment had no apparent adverse effects on the experimental model. In contrast, the analgesic treatment improved the model by minimizing stress-associated confounding variables in the experimental animals.

Original language	English
Journal	In Vivo
Volume	24
Issue number	5
Pages (from-to)	641-646
Number of pages	5
ISSN	0258-851X
Publication status	Published - Sept 2010

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title = "The effect of voluntarily ingested buprenorphine on rats subjected to surgically induced global cerebral ischaemia",

abstract = "The effect of perioperatively administered buprenorphine analgesia on rats subjected to surgically induced global ischaemia was assessed. Rats supplied with buprenorphine, mixed in nut paste for voluntary ingestion, displayed significant reductions in postoperative excretions of faecal corticosterone, in both magnitude and variance. This is indicative of lowered stress levels and less inter-animal metabolic variation. Although corticosterone has been reported to modulate the extent of cerebral damage, histology of coronal sections exhibited no differences in the extent of the ischaemia in buprenorphine-treated and untreated animals. A part from a slightly higher hyperthermia immediately after surgery and typical opiate-associated behaviour, the buprenorphine treatment had no apparent adverse effects on the experimental model. In contrast, the analgesic treatment improved the model by minimizing stress-associated confounding variables in the experimental animals.",

author = "Kalliokoski, {Otto Henrik} and Klas Abelson and Janne Koch and Anna Boschian and Thormose, {Sarah F} and Natasha Fauerby and Rasmussen, {Rune Skovgaard} and Johansen, {Flemming Fryd} and Jann Hau",

year = "2010",

month = sep,

language = "English",

volume = "24",

pages = "641--646",

journal = "In Vivo",

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TY - JOUR

T1 - The effect of voluntarily ingested buprenorphine on rats subjected to surgically induced global cerebral ischaemia

AU - Kalliokoski, Otto Henrik

AU - Abelson, Klas

AU - Koch, Janne

AU - Boschian, Anna

AU - Thormose, Sarah F

AU - Fauerby, Natasha

AU - Rasmussen, Rune Skovgaard

AU - Johansen, Flemming Fryd

AU - Hau, Jann

PY - 2010/9

Y1 - 2010/9

N2 - The effect of perioperatively administered buprenorphine analgesia on rats subjected to surgically induced global ischaemia was assessed. Rats supplied with buprenorphine, mixed in nut paste for voluntary ingestion, displayed significant reductions in postoperative excretions of faecal corticosterone, in both magnitude and variance. This is indicative of lowered stress levels and less inter-animal metabolic variation. Although corticosterone has been reported to modulate the extent of cerebral damage, histology of coronal sections exhibited no differences in the extent of the ischaemia in buprenorphine-treated and untreated animals. A part from a slightly higher hyperthermia immediately after surgery and typical opiate-associated behaviour, the buprenorphine treatment had no apparent adverse effects on the experimental model. In contrast, the analgesic treatment improved the model by minimizing stress-associated confounding variables in the experimental animals.

AB - The effect of perioperatively administered buprenorphine analgesia on rats subjected to surgically induced global ischaemia was assessed. Rats supplied with buprenorphine, mixed in nut paste for voluntary ingestion, displayed significant reductions in postoperative excretions of faecal corticosterone, in both magnitude and variance. This is indicative of lowered stress levels and less inter-animal metabolic variation. Although corticosterone has been reported to modulate the extent of cerebral damage, histology of coronal sections exhibited no differences in the extent of the ischaemia in buprenorphine-treated and untreated animals. A part from a slightly higher hyperthermia immediately after surgery and typical opiate-associated behaviour, the buprenorphine treatment had no apparent adverse effects on the experimental model. In contrast, the analgesic treatment improved the model by minimizing stress-associated confounding variables in the experimental animals.

M3 - Journal article

SN - 0258-851X

VL - 24

SP - 641

EP - 646

JO - In Vivo

JF - In Vivo

IS - 5

ER -

The effect of voluntarily ingested buprenorphine on rats subjected to surgically induced global cerebral ischaemia

Abstract

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