The effect of sumatriptan on cephalic arteries: A 3T MR-angiography study in healthy volunteers

Faisal Mohammad Amin; Mohammad Sohail Asghar; Julie W Ravneberg; Patrick Jh de Koning; Henrik Bw Larsson; Jes Olesen; Messoud Ashina

doi:10.1177/0333102413483374

The effect of sumatriptan on cephalic arteries: A 3T MR-angiography study in healthy volunteers

Faisal Mohammad Amin, Mohammad Sohail Asghar, Julie W Ravneberg, Patrick Jh de Koning, Henrik Bw Larsson, Jes Olesen, Messoud Ashina

27 Citations (Scopus)

Abstract

AIM: To explore a possible differential effect of sumatriptan on extracerebral versus cerebral arteries, we examined the superficial temporal (STA), middle meningeal (MMA), extracranial internal carotid (ICAextra), intracranial internal carotid (ICAintra), middle cerebral (MCA) and basilar arteries (BA). METHODS: The arterial circumferences were recorded blindly using high-resolution magnetic resonance angiography before and after subcutaneous sumatriptan injection (6 mg) in 18 healthy volunteers. RESULTS: We found significant constrictions of MMA (16.5%), STA (16.4%) and ICAextra (15.2%) ( P ≤ 0.001). Smaller, but statistically significant, constrictions were seen in MCA (5.5%) and BA (2.1%) ( P ≤ 0.012). ICAintra change 1.8% was not significant ( P = 0.179). The constriction of cerebral arteries was significantly smaller than the constriction of extracerebral arteries ( P

Original language	English
Journal	Cephalalgia
ISSN	0333-1024
DOIs	https://doi.org/10.1177/0333102413483374
Publication status	Published - Sept 2013

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title = "The effect of sumatriptan on cephalic arteries: A 3T MR-angiography study in healthy volunteers",

abstract = "AIM: To explore a possible differential effect of sumatriptan on extracerebral versus cerebral arteries, we examined the superficial temporal (STA), middle meningeal (MMA), extracranial internal carotid (ICAextra), intracranial internal carotid (ICAintra), middle cerebral (MCA) and basilar arteries (BA). METHODS: The arterial circumferences were recorded blindly using high-resolution magnetic resonance angiography before and after subcutaneous sumatriptan injection (6 mg) in 18 healthy volunteers. RESULTS: We found significant constrictions of MMA (16.5%), STA (16.4%) and ICAextra (15.2%) ( P ≤ 0.001). Smaller, but statistically significant, constrictions were seen in MCA (5.5%) and BA (2.1%) ( P ≤ 0.012). ICAintra change 1.8% was not significant ( P = 0.179). The constriction of cerebral arteries was significantly smaller than the constriction of extracerebral arteries ( P ",

author = "Amin, {Faisal Mohammad} and Asghar, {Mohammad Sohail} and Ravneberg, {Julie W} and {de Koning}, {Patrick Jh} and Larsson, {Henrik Bw} and Jes Olesen and Messoud Ashina",

year = "2013",

month = sep,

doi = "10.1177/0333102413483374",

language = "English",

journal = "Cephalalgia",

issn = "0333-1024",

publisher = "SAGE Publications",

}

TY - JOUR

T1 - The effect of sumatriptan on cephalic arteries

T2 - A 3T MR-angiography study in healthy volunteers

AU - Amin, Faisal Mohammad

AU - Asghar, Mohammad Sohail

AU - Ravneberg, Julie W

AU - de Koning, Patrick Jh

AU - Larsson, Henrik Bw

AU - Olesen, Jes

AU - Ashina, Messoud

PY - 2013/9

Y1 - 2013/9

N2 - AIM: To explore a possible differential effect of sumatriptan on extracerebral versus cerebral arteries, we examined the superficial temporal (STA), middle meningeal (MMA), extracranial internal carotid (ICAextra), intracranial internal carotid (ICAintra), middle cerebral (MCA) and basilar arteries (BA). METHODS: The arterial circumferences were recorded blindly using high-resolution magnetic resonance angiography before and after subcutaneous sumatriptan injection (6 mg) in 18 healthy volunteers. RESULTS: We found significant constrictions of MMA (16.5%), STA (16.4%) and ICAextra (15.2%) ( P ≤ 0.001). Smaller, but statistically significant, constrictions were seen in MCA (5.5%) and BA (2.1%) ( P ≤ 0.012). ICAintra change 1.8% was not significant ( P = 0.179). The constriction of cerebral arteries was significantly smaller than the constriction of extracerebral arteries ( P

AB - AIM: To explore a possible differential effect of sumatriptan on extracerebral versus cerebral arteries, we examined the superficial temporal (STA), middle meningeal (MMA), extracranial internal carotid (ICAextra), intracranial internal carotid (ICAintra), middle cerebral (MCA) and basilar arteries (BA). METHODS: The arterial circumferences were recorded blindly using high-resolution magnetic resonance angiography before and after subcutaneous sumatriptan injection (6 mg) in 18 healthy volunteers. RESULTS: We found significant constrictions of MMA (16.5%), STA (16.4%) and ICAextra (15.2%) ( P ≤ 0.001). Smaller, but statistically significant, constrictions were seen in MCA (5.5%) and BA (2.1%) ( P ≤ 0.012). ICAintra change 1.8% was not significant ( P = 0.179). The constriction of cerebral arteries was significantly smaller than the constriction of extracerebral arteries ( P

U2 - 10.1177/0333102413483374

DO - 10.1177/0333102413483374

M3 - Journal article

C2 - 23588794

SN - 0333-1024

JO - Cephalalgia

JF - Cephalalgia

ER -

The effect of sumatriptan on cephalic arteries: A 3T MR-angiography study in healthy volunteers

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