The effect of physical exercise on cerebral blood flow in Alzheimer's disease

Lisa A van der Kleij; Esben T Petersen; Hartwig R Siebner; Jeroen Hendrikse; Kristian S Frederiksen; Nanna A Sobol; Steen G Hasselbalch; Ellen Garde

doi:10.1016/j.nicl.2018.09.003

The effect of physical exercise on cerebral blood flow in Alzheimer's disease

Lisa A van der Kleij, Esben T Petersen, Hartwig R Siebner, Jeroen Hendrikse, Kristian S Frederiksen, Nanna A Sobol, Steen G Hasselbalch, Ellen Garde

Department of Clinical Medicine

22 Citations (Scopus)

42 Downloads (Pure)

Abstract

In recent years there has been an increasing focus on the relation between cerebrovascular health, physical exercise and Alzheimer's disease. The aim of the current study was to determine the effect of moderate-to-high-intensity aerobic exercise on cerebral blood flow in patients with mild to moderate Alzheimer's disease. Fifty-one patients were randomized to either usual care or moderate-to-high intensity aerobic exercise for 16 weeks. Exercise had no consistent effect on whole brain or regional cerebral blood flow. Sixteen weeks of exercise are, therefore, not sufficient to produce a consistent increase in cerebral blood flow in a relatively small sample of Alzheimer's patients.

Original language	English
Journal	NeuroImage: Clinical
Volume	20
Pages (from-to)	650-654
ISSN	2213-1582
DOIs	https://doi.org/10.1016/j.nicl.2018.09.003
Publication status	Published - 2018

Keywords

Aged
Alzheimer Disease/diagnosis
Brief Psychiatric Rating Scale
Cerebrovascular Circulation/physiology
Exercise/physiology
Female
Follow-Up Studies
Humans
Male
Middle Aged
Single-Blind Method

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1-s2.0-S2213158218302778-mainFinal published version, 511 KBLicence: CC BY-NC-ND

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title = "The effect of physical exercise on cerebral blood flow in Alzheimer's disease",

abstract = "In recent years there has been an increasing focus on the relation between cerebrovascular health, physical exercise and Alzheimer's disease. The aim of the current study was to determine the effect of moderate-to-high-intensity aerobic exercise on cerebral blood flow in patients with mild to moderate Alzheimer's disease. Fifty-one patients were randomized to either usual care or moderate-to-high intensity aerobic exercise for 16 weeks. Exercise had no consistent effect on whole brain or regional cerebral blood flow. Sixteen weeks of exercise are, therefore, not sufficient to produce a consistent increase in cerebral blood flow in a relatively small sample of Alzheimer's patients.",

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year = "2018",

doi = "10.1016/j.nicl.2018.09.003",

language = "English",

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pages = "650--654",

journal = "NeuroImage: Clinical",

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T1 - The effect of physical exercise on cerebral blood flow in Alzheimer's disease

AU - van der Kleij, Lisa A

AU - Petersen, Esben T

AU - Siebner, Hartwig R

AU - Hendrikse, Jeroen

AU - Frederiksen, Kristian S

AU - Sobol, Nanna A

AU - Hasselbalch, Steen G

AU - Garde, Ellen

PY - 2018

Y1 - 2018

N2 - In recent years there has been an increasing focus on the relation between cerebrovascular health, physical exercise and Alzheimer's disease. The aim of the current study was to determine the effect of moderate-to-high-intensity aerobic exercise on cerebral blood flow in patients with mild to moderate Alzheimer's disease. Fifty-one patients were randomized to either usual care or moderate-to-high intensity aerobic exercise for 16 weeks. Exercise had no consistent effect on whole brain or regional cerebral blood flow. Sixteen weeks of exercise are, therefore, not sufficient to produce a consistent increase in cerebral blood flow in a relatively small sample of Alzheimer's patients.

AB - In recent years there has been an increasing focus on the relation between cerebrovascular health, physical exercise and Alzheimer's disease. The aim of the current study was to determine the effect of moderate-to-high-intensity aerobic exercise on cerebral blood flow in patients with mild to moderate Alzheimer's disease. Fifty-one patients were randomized to either usual care or moderate-to-high intensity aerobic exercise for 16 weeks. Exercise had no consistent effect on whole brain or regional cerebral blood flow. Sixteen weeks of exercise are, therefore, not sufficient to produce a consistent increase in cerebral blood flow in a relatively small sample of Alzheimer's patients.

KW - Aged

KW - Alzheimer Disease/diagnosis

KW - Brief Psychiatric Rating Scale

KW - Cerebrovascular Circulation/physiology

KW - Exercise/physiology

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Male

KW - Middle Aged

KW - Single-Blind Method

U2 - 10.1016/j.nicl.2018.09.003

DO - 10.1016/j.nicl.2018.09.003

M3 - Journal article

C2 - 30211001

SN - 2213-1582

VL - 20

SP - 650

EP - 654

JO - NeuroImage: Clinical

JF - NeuroImage: Clinical

ER -

The effect of physical exercise on cerebral blood flow in Alzheimer's disease

Abstract

Keywords

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