The effect of olive oil polyphenols on antibodies against oxidized LDL. A randomized clinical trial

Olga Castañer; Montserrat Fitó; M Carmen López-Sabater; Henrik E Poulsen; Kristiina Nyyssönen; Helmut Schröder; Jukka T Salonen; Karina De la Torre-Carbot; Hans-Franz Zunft; Rafael De la Torre; Hans Bäumler; Antonio V Gaddi; Guillermo T Saez; Marta Tomás; Maria-Isabel Covas; for the EUROLIVE Study Group; Helmut Schröder

doi:10.1016/j.clnu.2011.01.013

The effect of olive oil polyphenols on antibodies against oxidized LDL. A randomized clinical trial

Olga Castañer, Montserrat Fitó, M Carmen López-Sabater, Henrik E Poulsen, Kristiina Nyyssönen, Helmut Schröder, Jukka T Salonen, Karina De la Torre-Carbot, Hans-Franz Zunft, Rafael De la Torre, Hans Bäumler, Antonio V Gaddi, Guillermo T Saez, Marta Tomás, Maria-Isabel Covas, for the EUROLIVE Study Group, Helmut Schröder

54 Citations (Scopus)

Abstract

BACKGROUND & AIM: Oxidized LDL (oxLDL) is a highly immunogenic particle that plays a key role in the development of atherosclerosis. Some data suggest a protective role of OxLDL autoantibodies (OLAB) in atherosclerosis. Our aim was to assess the effect of olive oil polyphenols on the immunogenicity of oxLDL to autoantibody generation. METHODS: In a crossover, controlled trial, 200 healthy men were randomly assigned to 3-week sequences of 25 mL/day of 3 olive oils with high (366 mg/kg), medium (164 mg/kg), and low (2.7 mg/kg) phenolic content. RESULTS: Plasma OLAB concentration was inversely associated with oxLDL (p

Original language	English
Journal	Clinical Nutrition
Volume	30
Issue number	4
Pages (from-to)	490-493
ISSN	0261-5614
DOIs	https://doi.org/10.1016/j.clnu.2011.01.013
Publication status	Published - Aug 2011

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Castañer, O., Fitó, M., López-Sabater, M. C., Poulsen, H. E., Nyyssönen, K., Schröder, H., Salonen, J. T., De la Torre-Carbot, K., Zunft, H-F., De la Torre, R., Bäumler, H., Gaddi, A. V., Saez, G. T., Tomás, M., Covas, M-I., for the EUROLIVE Study Group, & Schröder, H. (2011). The effect of olive oil polyphenols on antibodies against oxidized LDL. A randomized clinical trial. Clinical Nutrition, 30(4), 490-493. https://doi.org/10.1016/j.clnu.2011.01.013

Castañer, O, Fitó, M, López-Sabater, MC, Poulsen, HE, Nyyssönen, K, Schröder, H, Salonen, JT, De la Torre-Carbot, K, Zunft, H-F, De la Torre, R, Bäumler, H, Gaddi, AV, Saez, GT, Tomás, M, Covas, M-I, for the EUROLIVE Study Group & Schröder, H 2011, 'The effect of olive oil polyphenols on antibodies against oxidized LDL. A randomized clinical trial', Clinical Nutrition, vol. 30, no. 4, pp. 490-493. https://doi.org/10.1016/j.clnu.2011.01.013

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title = "The effect of olive oil polyphenols on antibodies against oxidized LDL. A randomized clinical trial",

abstract = "BACKGROUND & AIM: Oxidized LDL (oxLDL) is a highly immunogenic particle that plays a key role in the development of atherosclerosis. Some data suggest a protective role of OxLDL autoantibodies (OLAB) in atherosclerosis. Our aim was to assess the effect of olive oil polyphenols on the immunogenicity of oxLDL to autoantibody generation. METHODS: In a crossover, controlled trial, 200 healthy men were randomly assigned to 3-week sequences of 25 mL/day of 3 olive oils with high (366 mg/kg), medium (164 mg/kg), and low (2.7 mg/kg) phenolic content. RESULTS: Plasma OLAB concentration was inversely associated with oxLDL (p ",

author = "Olga Casta{\~n}er and Montserrat Fit{\'o} and L{\'o}pez-Sabater, {M Carmen} and Poulsen, {Henrik E} and Kristiina Nyyss{\"o}nen and Helmut Schr{\"o}der and Salonen, {Jukka T} and {De la Torre-Carbot}, Karina and Hans-Franz Zunft and {De la Torre}, Rafael and Hans B{\"a}umler and Gaddi, {Antonio V} and Saez, {Guillermo T} and Marta Tom{\'a}s and Maria-Isabel Covas and Poulsen, {Henrik Enghusen} and Helmut Schr{\"o}der",

year = "2011",

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doi = "10.1016/j.clnu.2011.01.013",

language = "English",

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T1 - The effect of olive oil polyphenols on antibodies against oxidized LDL. A randomized clinical trial

AU - Castañer, Olga

AU - Fitó, Montserrat

AU - López-Sabater, M Carmen

AU - Poulsen, Henrik E

AU - Nyyssönen, Kristiina

AU - Schröder, Helmut

AU - Salonen, Jukka T

AU - De la Torre-Carbot, Karina

AU - Zunft, Hans-Franz

AU - De la Torre, Rafael

AU - Bäumler, Hans

AU - Gaddi, Antonio V

AU - Saez, Guillermo T

AU - Tomás, Marta

AU - Covas, Maria-Isabel

AU - for the EUROLIVE Study Group

AU - Schröder, Helmut

PY - 2011/8

Y1 - 2011/8

N2 - BACKGROUND & AIM: Oxidized LDL (oxLDL) is a highly immunogenic particle that plays a key role in the development of atherosclerosis. Some data suggest a protective role of OxLDL autoantibodies (OLAB) in atherosclerosis. Our aim was to assess the effect of olive oil polyphenols on the immunogenicity of oxLDL to autoantibody generation. METHODS: In a crossover, controlled trial, 200 healthy men were randomly assigned to 3-week sequences of 25 mL/day of 3 olive oils with high (366 mg/kg), medium (164 mg/kg), and low (2.7 mg/kg) phenolic content. RESULTS: Plasma OLAB concentration was inversely associated with oxLDL (p

AB - BACKGROUND & AIM: Oxidized LDL (oxLDL) is a highly immunogenic particle that plays a key role in the development of atherosclerosis. Some data suggest a protective role of OxLDL autoantibodies (OLAB) in atherosclerosis. Our aim was to assess the effect of olive oil polyphenols on the immunogenicity of oxLDL to autoantibody generation. METHODS: In a crossover, controlled trial, 200 healthy men were randomly assigned to 3-week sequences of 25 mL/day of 3 olive oils with high (366 mg/kg), medium (164 mg/kg), and low (2.7 mg/kg) phenolic content. RESULTS: Plasma OLAB concentration was inversely associated with oxLDL (p

U2 - 10.1016/j.clnu.2011.01.013

DO - 10.1016/j.clnu.2011.01.013

M3 - Journal article

SN - 0261-5614

VL - 30

SP - 490

EP - 493

JO - Clinical Nutrition

JF - Clinical Nutrition

IS - 4

ER -

The effect of olive oil polyphenols on antibodies against oxidized LDL. A randomized clinical trial

Abstract

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