The effect of nutritional supplementation on quality of life in people living with HIV: a randomized controlled trial

TY - JOUR

T1 - The effect of nutritional supplementation on quality of life in people living with HIV

T2 - a randomized controlled trial

AU - Tesfaye Woldeyohannes, Markos

AU - Kæstel, Pernille

AU - Olsen, Mette Frahm

AU - Girma, Tsinuel

AU - Yilma, Daniel

AU - Abdissa, Alemseged

AU - Ritz, Christian

AU - Michaelsen, Kim F.

AU - Hanlon, Charlotte

AU - Friis, Henrik

N1 - CURIS 2016 NEXS 138

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Objective: To determine the effects of lipid-based nutrient supplements (LNS) on the quality of life of people living with HIV (PLHIV) during the first 3 months of antiretroviral treatment (ART) and to investigate the effects of timing of supplementation by comparing with supplementation during the subsequent 3 months. Methods: A randomised controlled trial was conducted in three ART clinics within public health facilities in Jimma, Ethiopia. Participants were PLHIV eligible to start ART with body mass index >17 kg/m2 and given daily supplements of 200 g of LNS containing whey or soya either during the first 3 months or the subsequent months of ART. The outcome was measured in terms of total quality-of-life scores on the adapted version of the WHOQOL-HIV-BREF assessed at baseline, three and six months. Results: Of the 282 participants, 186 (66.0%) were women. The mean age (SD) was 32.8 (±9.0) years, and the mean (SD) total quality-of-life score was 82.0 (±14.8) at baseline assessment. At 3 months, participants who received LNS showed better quality of life than those who only received ART without LNS (β = 6.2, 95% CI: 2.9: 9.6). At 6 months, there was no difference in total quality-of-life score between the early and delayed supplementation groups (β = 3.0, 95% CI: -0.4: 6.4). However, the early supplementation group showed higher scores on the social and spirituality domains than the delayed group. Conclusions: LNS given during the first three months of ART improves the quality of life of PLHIV.

AB - Objective: To determine the effects of lipid-based nutrient supplements (LNS) on the quality of life of people living with HIV (PLHIV) during the first 3 months of antiretroviral treatment (ART) and to investigate the effects of timing of supplementation by comparing with supplementation during the subsequent 3 months. Methods: A randomised controlled trial was conducted in three ART clinics within public health facilities in Jimma, Ethiopia. Participants were PLHIV eligible to start ART with body mass index >17 kg/m2 and given daily supplements of 200 g of LNS containing whey or soya either during the first 3 months or the subsequent months of ART. The outcome was measured in terms of total quality-of-life scores on the adapted version of the WHOQOL-HIV-BREF assessed at baseline, three and six months. Results: Of the 282 participants, 186 (66.0%) were women. The mean age (SD) was 32.8 (±9.0) years, and the mean (SD) total quality-of-life score was 82.0 (±14.8) at baseline assessment. At 3 months, participants who received LNS showed better quality of life than those who only received ART without LNS (β = 6.2, 95% CI: 2.9: 9.6). At 6 months, there was no difference in total quality-of-life score between the early and delayed supplementation groups (β = 3.0, 95% CI: -0.4: 6.4). However, the early supplementation group showed higher scores on the social and spirituality domains than the delayed group. Conclusions: LNS given during the first three months of ART improves the quality of life of PLHIV.

U2 - 10.1111/tmi.12705

DO - 10.1111/tmi.12705

M3 - Journal article

C2 - 27115126

SN - 1360-2276

VL - 21

SP - 735

EP - 742

JO - Tropical Medicine & International Health

JF - Tropical Medicine & International Health

IS - 6

ER -