The effect of GWAS identified BMI loci on changes in body weight among middle-aged danes during a five year period

Camilla Helene Sandholt; Kristine Højgaard Allin; U Toft; A Borglykke; Rasmus Ribel-Madsen; Thomas Hempel Sparsø; Johanne Marie Justesen; Marie Neergaard Harder; Torben Jørgensen; Torben Hansen; O Pedersen

doi:10.1002/oby.20540

The effect of GWAS identified BMI loci on changes in body weight among middle-aged danes during a five year period

Camilla Helene Sandholt, Kristine Højgaard Allin, U Toft, A Borglykke, Rasmus Ribel-Madsen, Thomas Hempel Sparsø, Johanne Marie Justesen, Marie Neergaard Harder, Torben Jørgensen, Torben Hansen, O Pedersen

23 Citations (Scopus)

Abstract

Objective Genome-wide association studies have identified genetic variants associating with BMI, however, it is un-clarified whether the same variants also influence body weight fluctuations. Methods Among 3,982 adult individuals that attended both a baseline and a five-year follow-up examination in the Danish Inter99 intervention study, a genetic risk score (GRS) was constructed based on 30 BMI variants to address whether it is associated with body weight changes. Moreover, it was examined whether the effect of lifestyle changes was modulated by the GRS. Results The GRS associated strongly with baseline body weight, with a per risk allele increase of 0.45 (0.33-0.58) kg (P = 2.7 × 10 ^-12), corresponding to a body weight difference of 3.41 (2.21-4.60) kg comparing the highest (≥ 30 risk alleles) and lowest (≤ 26 risk alleles) risk allele tertile. No association was observed with changes in body weight during the five years. Changes in lifestyle, including physical activity, diet and smoking habits associated strongly with body weight changes, however, no interactions with the GRS was observed. Conclusion The GRS associated with body weight cross-sectionally, but not with changes over a five-year period. Body weight changes were influenced by lifestyle changes, however, independently of the GRS.

Original language	English
Journal	Obesity
Volume	22
Issue number	3
Pages (from-to)	901-908
Number of pages	9
ISSN	1930-7381
DOIs	https://doi.org/10.1002/oby.20540
Publication status	Published - Mar 2014

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@article{424177cd7c9440818fd54d026fa5ffa1,

title = "The effect of GWAS identified BMI loci on changes in body weight among middle-aged danes during a five year period",

abstract = "Objective Genome-wide association studies have identified genetic variants associating with BMI, however, it is un-clarified whether the same variants also influence body weight fluctuations. Methods Among 3,982 adult individuals that attended both a baseline and a five-year follow-up examination in the Danish Inter99 intervention study, a genetic risk score (GRS) was constructed based on 30 BMI variants to address whether it is associated with body weight changes. Moreover, it was examined whether the effect of lifestyle changes was modulated by the GRS. Results The GRS associated strongly with baseline body weight, with a per risk allele increase of 0.45 (0.33-0.58) kg (P = 2.7 × 10 -12), corresponding to a body weight difference of 3.41 (2.21-4.60) kg comparing the highest (≥ 30 risk alleles) and lowest (≤ 26 risk alleles) risk allele tertile. No association was observed with changes in body weight during the five years. Changes in lifestyle, including physical activity, diet and smoking habits associated strongly with body weight changes, however, no interactions with the GRS was observed. Conclusion The GRS associated with body weight cross-sectionally, but not with changes over a five-year period. Body weight changes were influenced by lifestyle changes, however, independently of the GRS.",

author = "Sandholt, {Camilla Helene} and Allin, {Kristine H{\o}jgaard} and U Toft and A Borglykke and Rasmus Ribel-Madsen and Spars{\o}, {Thomas Hempel} and Justesen, {Johanne Marie} and Harder, {Marie Neergaard} and Torben J{\o}rgensen and Torben Hansen and O Pedersen",

note = "Copyright {\textcopyright} 2013 The Obesity Society.",

year = "2014",

month = mar,

doi = "10.1002/oby.20540",

language = "English",

volume = "22",

pages = "901--908",

journal = "Obesity",

issn = "1930-7381",

publisher = "Wiley-Blackwell",

number = "3",

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TY - JOUR

T1 - The effect of GWAS identified BMI loci on changes in body weight among middle-aged danes during a five year period

AU - Sandholt, Camilla Helene

AU - Allin, Kristine Højgaard

AU - Toft, U

AU - Borglykke, A

AU - Ribel-Madsen, Rasmus

AU - Sparsø, Thomas Hempel

AU - Justesen, Johanne Marie

AU - Harder, Marie Neergaard

AU - Jørgensen, Torben

AU - Hansen, Torben

AU - Pedersen, O

PY - 2014/3

Y1 - 2014/3

N2 - Objective Genome-wide association studies have identified genetic variants associating with BMI, however, it is un-clarified whether the same variants also influence body weight fluctuations. Methods Among 3,982 adult individuals that attended both a baseline and a five-year follow-up examination in the Danish Inter99 intervention study, a genetic risk score (GRS) was constructed based on 30 BMI variants to address whether it is associated with body weight changes. Moreover, it was examined whether the effect of lifestyle changes was modulated by the GRS. Results The GRS associated strongly with baseline body weight, with a per risk allele increase of 0.45 (0.33-0.58) kg (P = 2.7 × 10 -12), corresponding to a body weight difference of 3.41 (2.21-4.60) kg comparing the highest (≥ 30 risk alleles) and lowest (≤ 26 risk alleles) risk allele tertile. No association was observed with changes in body weight during the five years. Changes in lifestyle, including physical activity, diet and smoking habits associated strongly with body weight changes, however, no interactions with the GRS was observed. Conclusion The GRS associated with body weight cross-sectionally, but not with changes over a five-year period. Body weight changes were influenced by lifestyle changes, however, independently of the GRS.

AB - Objective Genome-wide association studies have identified genetic variants associating with BMI, however, it is un-clarified whether the same variants also influence body weight fluctuations. Methods Among 3,982 adult individuals that attended both a baseline and a five-year follow-up examination in the Danish Inter99 intervention study, a genetic risk score (GRS) was constructed based on 30 BMI variants to address whether it is associated with body weight changes. Moreover, it was examined whether the effect of lifestyle changes was modulated by the GRS. Results The GRS associated strongly with baseline body weight, with a per risk allele increase of 0.45 (0.33-0.58) kg (P = 2.7 × 10 -12), corresponding to a body weight difference of 3.41 (2.21-4.60) kg comparing the highest (≥ 30 risk alleles) and lowest (≤ 26 risk alleles) risk allele tertile. No association was observed with changes in body weight during the five years. Changes in lifestyle, including physical activity, diet and smoking habits associated strongly with body weight changes, however, no interactions with the GRS was observed. Conclusion The GRS associated with body weight cross-sectionally, but not with changes over a five-year period. Body weight changes were influenced by lifestyle changes, however, independently of the GRS.

U2 - 10.1002/oby.20540

DO - 10.1002/oby.20540

M3 - Journal article

C2 - 23804573

SN - 1930-7381

VL - 22

SP - 901

EP - 908

JO - Obesity

JF - Obesity

IS - 3

ER -

The effect of GWAS identified BMI loci on changes in body weight among middle-aged danes during a five year period

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