The effect of fatty acid positioning in dietary triacylglycerols and intake of long-chain n-3 polyunsaturated fatty acids on bone mineral accretion in growing piglets

Anders Daniel Andersen; Stine E Ludvig; Camilla Trab Damsgaard; Pasi Pulkkinen; Mikko Finnilä; Huiling Mu; Thomas Thymann; Kim F. Michaelsen; Christian Mølgaard; Lotte Lauritzen

doi:10.1016/j.plefa.2013.06.006

The effect of fatty acid positioning in dietary triacylglycerols and intake of long-chain n-3 polyunsaturated fatty acids on bone mineral accretion in growing piglets

Anders Daniel Andersen, Stine E Ludvig, Camilla Trab Damsgaard, Pasi Pulkkinen, Mikko Finnilä, Huiling Mu, Thomas Thymann, Kim F. Michaelsen, Christian Mølgaard, Lotte Lauritzen

Lifecourse Nutrition & Health

4 Citations (Scopus)

Abstract

Long-chain n-3 PUFA (LCPUFA) and palmitate (16:0) positioning in the triacylglycerol (TAG) of infant formula may affect calcium-uptake which could affect bone health. We investigated if a human milk fat substitute (HMFS) with a modified TAG structure holding 16:0 predominantly in the sn-2-position compared with a control (CONT) and if increasing n-3LCPUFA intake giving fish oil (FO) compared with sunflower oil (SO) would affect bone parameters in piglets in two sets of controlled 14d-interventions (n=12/group). We assessed this by dual-energy x-ray absorptiometry, and ex vivo peripheral quantitative computed tomography and mechanical strength. Bone mineral content (BMC) was higher in the FO compared to the SO-group (p=0.03). Despite similar weight gain in HMFS- and CONT-groups, body fat accumulation was higher with HMFS (p

Original language	English
Journal	Prostaglandins, Leukotrienes & Essential Fatty Acids
Volume	89
Issue number	4
Pages (from-to)	235-240
Number of pages	6
ISSN	0952-3278
DOIs	https://doi.org/10.1016/j.plefa.2013.06.006
Publication status	Published - Sept 2013

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Andersen, A. D., Ludvig, S. E., Damsgaard, C. T., Pulkkinen, P., Finnilä, M., Mu, H., Thymann, T., Michaelsen, K. F., Mølgaard, C., & Lauritzen, L. (2013). The effect of fatty acid positioning in dietary triacylglycerols and intake of long-chain n-3 polyunsaturated fatty acids on bone mineral accretion in growing piglets. Prostaglandins, Leukotrienes & Essential Fatty Acids, 89(4), 235-240. https://doi.org/10.1016/j.plefa.2013.06.006

The effect of fatty acid positioning in dietary triacylglycerols and intake of long-chain n-3 polyunsaturated fatty acids on bone mineral accretion in growing piglets. / Andersen, Anders Daniel; Ludvig, Stine E; Damsgaard, Camilla Trab et al.
In: Prostaglandins, Leukotrienes & Essential Fatty Acids, Vol. 89, No. 4, 09.2013, p. 235-240.

Research output: Contribution to journal › Journal article › Research › peer-review

Andersen, AD, Ludvig, SE, Damsgaard, CT, Pulkkinen, P, Finnilä, M, Mu, H , Thymann, T , Michaelsen, KF , Mølgaard, C & Lauritzen, L 2013, 'The effect of fatty acid positioning in dietary triacylglycerols and intake of long-chain n-3 polyunsaturated fatty acids on bone mineral accretion in growing piglets', Prostaglandins, Leukotrienes & Essential Fatty Acids, vol. 89, no. 4, pp. 235-240. https://doi.org/10.1016/j.plefa.2013.06.006

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abstract = "Long-chain n-3 PUFA (LCPUFA) and palmitate (16:0) positioning in the triacylglycerol (TAG) of infant formula may affect calcium-uptake which could affect bone health. We investigated if a human milk fat substitute (HMFS) with a modified TAG structure holding 16:0 predominantly in the sn-2-position compared with a control (CONT) and if increasing n-3LCPUFA intake giving fish oil (FO) compared with sunflower oil (SO) would affect bone parameters in piglets in two sets of controlled 14d-interventions (n=12/group). We assessed this by dual-energy x-ray absorptiometry, and ex vivo peripheral quantitative computed tomography and mechanical strength. Bone mineral content (BMC) was higher in the FO compared to the SO-group (p=0.03). Despite similar weight gain in HMFS- and CONT-groups, body fat accumulation was higher with HMFS (p",

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AU - Pulkkinen, Pasi

AU - Finnilä, Mikko

AU - Mu, Huiling

AU - Thymann, Thomas

AU - Michaelsen, Kim F.

AU - Mølgaard, Christian

AU - Lauritzen, Lotte

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AB - Long-chain n-3 PUFA (LCPUFA) and palmitate (16:0) positioning in the triacylglycerol (TAG) of infant formula may affect calcium-uptake which could affect bone health. We investigated if a human milk fat substitute (HMFS) with a modified TAG structure holding 16:0 predominantly in the sn-2-position compared with a control (CONT) and if increasing n-3LCPUFA intake giving fish oil (FO) compared with sunflower oil (SO) would affect bone parameters in piglets in two sets of controlled 14d-interventions (n=12/group). We assessed this by dual-energy x-ray absorptiometry, and ex vivo peripheral quantitative computed tomography and mechanical strength. Bone mineral content (BMC) was higher in the FO compared to the SO-group (p=0.03). Despite similar weight gain in HMFS- and CONT-groups, body fat accumulation was higher with HMFS (p

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The effect of fatty acid positioning in dietary triacylglycerols and intake of long-chain n-3 polyunsaturated fatty acids on bone mineral accretion in growing piglets

Abstract

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