The effect of different lung densities on the accuracy of various radiotherapy dose calculation methods: implications for tumour coverage

Lasse Rye Aarup; Alan E Nahum; Christina Zacharatou; Trine Juhler-Nøttrup; Tommy Knöös; Håkan Nyström; Lena Specht; Elinore Wieslander; Stine S Korreman; Lasse Rye Aarup; Alan E Nahum; Christina Zacharatou; Trine Juhler-Nøttrup; Tommy Knöös; Håkan Nyström; Lena Specht; Elinore Wieslander; Stine Korreman

doi:10.1016/j.radonc.2009.01.008

The effect of different lung densities on the accuracy of various radiotherapy dose calculation methods: implications for tumour coverage

Lasse Rye Aarup, Alan E Nahum, Christina Zacharatou, Trine Juhler-Nøttrup, Tommy Knöös, Håkan Nyström, Lena Specht, Elinore Wieslander, Stine S Korreman, Lasse Rye Aarup, Alan E Nahum, Christina Zacharatou, Trine Juhler-Nøttrup, Tommy Knöös, Håkan Nyström, Lena Specht, Elinore Wieslander, Stine Korreman

103 Citations (Scopus)

Abstract

PURPOSE: To evaluate against Monte-Carlo the performance of various dose calculations algorithms regarding lung tumour coverage in stereotactic body radiotherapy (SBRT) conditions. MATERIALS AND METHODS: Dose distributions in virtual lung phantoms have been calculated using four commercial Treatment Planning System (TPS) algorithms and one Monte Carlo (MC) system (EGSnrc). We compared the performance of the algorithms in calculating the target dose for different degrees of lung inflation. The phantoms had a cubic 'body' and 'lung' and a central 2-cm diameter spherical 'tumour' (the body and tumour have unit density). The lung tissue was assigned five densities (rho(lung)): 0.01, 0.1, 0.2, 0.4 and 1g/cm(3). Four-field treatment plans were calculated with 6- and 18 MV narrow beams for each value of rho(lung). We considered the Pencil Beam Convolution (PBC(Ecl)) and the Analytical Anisotropic Algorithm (AAA(Ecl)) from Varian Eclipse and the Pencil Beam Convolution (PBC(OMP)) and the Collapsed Cone Convolution (CCC(OMP)) algorithms from Oncentra MasterPlan. RESULTS: When changing rho(lung) from 0.4 to 0.1g/cm(3), the MC median target dose decreased from 89.2% to 74.9% for 6 MV and from 83.3% to 61.6% for 18 MV (of dose maximum in the homogenous case at both energies), while for both PB algorithms the median target dose was virtually independent of lung density. CONCLUSIONS: Both PB algorithms overestimated the target dose, the overestimation increasing as rho(lung) decreased. Concerning target dose, the AAA(Ecl) and CCC(OMP) algorithms appear to be adequate alternatives to MC.

Original language	English
Journal	Radiotherapy & Oncology
Volume	91
Issue number	3
Pages (from-to)	405-14
Number of pages	10
ISSN	0167-8140
DOIs	https://doi.org/10.1016/j.radonc.2009.01.008 https://doi.org/10.1016/j.radonc.2009.01.008
Publication status	Published - 1 Jun 2009

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Aarup, L. R., Nahum, A. E., Zacharatou, C., Juhler-Nøttrup, T., Knöös, T., Nyström, H., Specht, L., Wieslander, E., Korreman, S. S., Aarup, L. R., Nahum, A. E., Zacharatou, C., Juhler-Nøttrup, T., Knöös, T., Nyström, H., Specht, L., Wieslander, E., & Korreman, S. (2009). The effect of different lung densities on the accuracy of various radiotherapy dose calculation methods: implications for tumour coverage. Radiotherapy & Oncology, 91(3), 405-14. https://doi.org/10.1016/j.radonc.2009.01.008, https://doi.org/10.1016/j.radonc.2009.01.008

Aarup, LR, Nahum, AE, Zacharatou, C, Juhler-Nøttrup, T, Knöös, T, Nyström, H, Specht, L, Wieslander, E, Korreman, SS, Aarup, LR, Nahum, AE, Zacharatou, C, Juhler-Nøttrup, T, Knöös, T, Nyström, H, Specht, L, Wieslander, E & Korreman, S 2009, 'The effect of different lung densities on the accuracy of various radiotherapy dose calculation methods: implications for tumour coverage', Radiotherapy & Oncology, vol. 91, no. 3, pp. 405-14. https://doi.org/10.1016/j.radonc.2009.01.008, https://doi.org/10.1016/j.radonc.2009.01.008

@article{d029ac20485b11df928f000ea68e967b,

title = "The effect of different lung densities on the accuracy of various radiotherapy dose calculation methods: implications for tumour coverage",

abstract = "PURPOSE: To evaluate against Monte-Carlo the performance of various dose calculations algorithms regarding lung tumour coverage in stereotactic body radiotherapy (SBRT) conditions. MATERIALS AND METHODS: Dose distributions in virtual lung phantoms have been calculated using four commercial Treatment Planning System (TPS) algorithms and one Monte Carlo (MC) system (EGSnrc). We compared the performance of the algorithms in calculating the target dose for different degrees of lung inflation. The phantoms had a cubic 'body' and 'lung' and a central 2-cm diameter spherical 'tumour' (the body and tumour have unit density). The lung tissue was assigned five densities (rho(lung)): 0.01, 0.1, 0.2, 0.4 and 1g/cm(3). Four-field treatment plans were calculated with 6- and 18 MV narrow beams for each value of rho(lung). We considered the Pencil Beam Convolution (PBC(Ecl)) and the Analytical Anisotropic Algorithm (AAA(Ecl)) from Varian Eclipse and the Pencil Beam Convolution (PBC(OMP)) and the Collapsed Cone Convolution (CCC(OMP)) algorithms from Oncentra MasterPlan. RESULTS: When changing rho(lung) from 0.4 to 0.1g/cm(3), the MC median target dose decreased from 89.2% to 74.9% for 6 MV and from 83.3% to 61.6% for 18 MV (of dose maximum in the homogenous case at both energies), while for both PB algorithms the median target dose was virtually independent of lung density. CONCLUSIONS: Both PB algorithms overestimated the target dose, the overestimation increasing as rho(lung) decreased. Concerning target dose, the AAA(Ecl) and CCC(OMP) algorithms appear to be adequate alternatives to MC.",

author = "Aarup, {Lasse Rye} and Nahum, {Alan E} and Christina Zacharatou and Trine Juhler-N{\o}ttrup and Tommy Kn{\"o}{\"o}s and H{\aa}kan Nystr{\"o}m and Lena Specht and Elinore Wieslander and Korreman, {Stine S} and Aarup, {Lasse Rye} and Nahum, {Alan E} and Christina Zacharatou and Trine Juhler-N{\o}ttrup and Tommy Kn{\"o}{\"o}s and H{\aa}kan Nystr{\"o}m and Lena Specht and Elinore Wieslander and Stine Korreman",

note = "Keywords: Algorithms; Anisotropy; Computer Simulation; Dose-Response Relationship, Radiation; Humans; Lung; Lung Neoplasms; Monte Carlo Method; Radiometry; Radiotherapy Dosage; Radiotherapy Planning, Computer-Assisted",

year = "2009",

month = jun,

day = "1",

doi = "10.1016/j.radonc.2009.01.008",

language = "English",

volume = "91",

pages = "405--14",

journal = "Radiotherapy & Oncology",

issn = "0167-8140",

publisher = "Elsevier Ireland Ltd",

number = "3",

}

TY - JOUR

T1 - The effect of different lung densities on the accuracy of various radiotherapy dose calculation methods: implications for tumour coverage

AU - Aarup, Lasse Rye

AU - Nahum, Alan E

AU - Zacharatou, Christina

AU - Juhler-Nøttrup, Trine

AU - Knöös, Tommy

AU - Nyström, Håkan

AU - Specht, Lena

AU - Wieslander, Elinore

AU - Korreman, Stine S

AU - Aarup, Lasse Rye

AU - Nahum, Alan E

AU - Zacharatou, Christina

AU - Juhler-Nøttrup, Trine

AU - Knöös, Tommy

AU - Nyström, Håkan

AU - Specht, Lena

AU - Wieslander, Elinore

AU - Korreman, Stine

N1 - Keywords: Algorithms; Anisotropy; Computer Simulation; Dose-Response Relationship, Radiation; Humans; Lung; Lung Neoplasms; Monte Carlo Method; Radiometry; Radiotherapy Dosage; Radiotherapy Planning, Computer-Assisted

PY - 2009/6/1

Y1 - 2009/6/1

N2 - PURPOSE: To evaluate against Monte-Carlo the performance of various dose calculations algorithms regarding lung tumour coverage in stereotactic body radiotherapy (SBRT) conditions. MATERIALS AND METHODS: Dose distributions in virtual lung phantoms have been calculated using four commercial Treatment Planning System (TPS) algorithms and one Monte Carlo (MC) system (EGSnrc). We compared the performance of the algorithms in calculating the target dose for different degrees of lung inflation. The phantoms had a cubic 'body' and 'lung' and a central 2-cm diameter spherical 'tumour' (the body and tumour have unit density). The lung tissue was assigned five densities (rho(lung)): 0.01, 0.1, 0.2, 0.4 and 1g/cm(3). Four-field treatment plans were calculated with 6- and 18 MV narrow beams for each value of rho(lung). We considered the Pencil Beam Convolution (PBC(Ecl)) and the Analytical Anisotropic Algorithm (AAA(Ecl)) from Varian Eclipse and the Pencil Beam Convolution (PBC(OMP)) and the Collapsed Cone Convolution (CCC(OMP)) algorithms from Oncentra MasterPlan. RESULTS: When changing rho(lung) from 0.4 to 0.1g/cm(3), the MC median target dose decreased from 89.2% to 74.9% for 6 MV and from 83.3% to 61.6% for 18 MV (of dose maximum in the homogenous case at both energies), while for both PB algorithms the median target dose was virtually independent of lung density. CONCLUSIONS: Both PB algorithms overestimated the target dose, the overestimation increasing as rho(lung) decreased. Concerning target dose, the AAA(Ecl) and CCC(OMP) algorithms appear to be adequate alternatives to MC.

AB - PURPOSE: To evaluate against Monte-Carlo the performance of various dose calculations algorithms regarding lung tumour coverage in stereotactic body radiotherapy (SBRT) conditions. MATERIALS AND METHODS: Dose distributions in virtual lung phantoms have been calculated using four commercial Treatment Planning System (TPS) algorithms and one Monte Carlo (MC) system (EGSnrc). We compared the performance of the algorithms in calculating the target dose for different degrees of lung inflation. The phantoms had a cubic 'body' and 'lung' and a central 2-cm diameter spherical 'tumour' (the body and tumour have unit density). The lung tissue was assigned five densities (rho(lung)): 0.01, 0.1, 0.2, 0.4 and 1g/cm(3). Four-field treatment plans were calculated with 6- and 18 MV narrow beams for each value of rho(lung). We considered the Pencil Beam Convolution (PBC(Ecl)) and the Analytical Anisotropic Algorithm (AAA(Ecl)) from Varian Eclipse and the Pencil Beam Convolution (PBC(OMP)) and the Collapsed Cone Convolution (CCC(OMP)) algorithms from Oncentra MasterPlan. RESULTS: When changing rho(lung) from 0.4 to 0.1g/cm(3), the MC median target dose decreased from 89.2% to 74.9% for 6 MV and from 83.3% to 61.6% for 18 MV (of dose maximum in the homogenous case at both energies), while for both PB algorithms the median target dose was virtually independent of lung density. CONCLUSIONS: Both PB algorithms overestimated the target dose, the overestimation increasing as rho(lung) decreased. Concerning target dose, the AAA(Ecl) and CCC(OMP) algorithms appear to be adequate alternatives to MC.

U2 - 10.1016/j.radonc.2009.01.008

DO - 10.1016/j.radonc.2009.01.008

M3 - Journal article

C2 - 19297051

SN - 0167-8140

VL - 91

SP - 405

EP - 414

JO - Radiotherapy & Oncology

JF - Radiotherapy & Oncology

IS - 3

ER -

The effect of different lung densities on the accuracy of various radiotherapy dose calculation methods: implications for tumour coverage

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