The EADC-ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance: Evidence of validity

Giovanni B Frisoni; Clifford R Jack; Martina Bocchetta; Corinna Bauer; Kristian S Frederiksen; Yawu Liu; Gregory Preboske; Tim Swihart; Melanie Blair; Enrica Cavedo; Michel J Grothe; Mariangela Lanfredi; Oliver Martinez; Masami Nishikawa; Marileen Portegies; Travis Stoub; Chadwich Ward; Liana G Apostolova; Rossana Ganzola; Dominik Wolf; Frederik Barkhof; George Bartzokis; Charles DeCarli; John G Csernansky; Leyla deToledo-Morrell; Mirjam I Geerlings; Jeffrey Kaye; Ronald J Killiany; Stephane Lehéricy; Hiroshi Matsuda; John O'Brien; Lisa C Silbert; Philip Scheltens; Hilkka Soininen; Stefan Teipel; Gunhild Waldemar; Andreas Fellgiebel; Josephine Barnes; Michael Firbank; Lotte Gerritsen; Wouter Henneman; Nikolai Malykhin; Jens C Pruessner; Lei Wang; Craig Watson; Henrike Wolf; Mony deLeon; Johannes Pantel; Clarissa Ferrari; Paolo Bosco; EADC-ADNI Working Group on The Harmonized Protocol for Manual Hippocampal Volumetry and for the Alzheimer's Disease Neuroimaging Initiative

doi:10.1016/j.jalz.2014.05.1756

The EADC-ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance: Evidence of validity

Giovanni B Frisoni, Clifford R Jack, Martina Bocchetta, Corinna Bauer, Kristian S Frederiksen, Yawu Liu, Gregory Preboske, Tim Swihart, Melanie Blair, Enrica Cavedo, Michel J Grothe, Mariangela Lanfredi, Oliver Martinez, Masami Nishikawa, Marileen Portegies, Travis Stoub, Chadwich Ward, Liana G Apostolova, Rossana Ganzola, Dominik WolfFrederik Barkhof, George Bartzokis, Charles DeCarli, John G Csernansky, Leyla deToledo-Morrell, Mirjam I Geerlings, Jeffrey Kaye, Ronald J Killiany, Stephane Lehéricy, Hiroshi Matsuda, John O'Brien, Lisa C Silbert, Philip Scheltens, Hilkka Soininen, Stefan Teipel, Gunhild Waldemar, Andreas Fellgiebel, Josephine Barnes, Michael Firbank, Lotte Gerritsen, Wouter Henneman, Nikolai Malykhin, Jens C Pruessner, Lei Wang, Craig Watson, Henrike Wolf, Mony deLeon, Johannes Pantel, Clarissa Ferrari, Paolo Bosco, EADC-ADNI Working Group on The Harmonized Protocol for Manual Hippocampal Volumetry and for the Alzheimer's Disease Neuroimaging Initiative

Department of Clinical Medicine

117 Citations (Scopus)

Abstract

Background: An international Delphi panel has defined a harmonized protocol (HarP) for the manual segmentation of the hippocampus on MR. The aim of this study is to study the concurrent validity of the HarP toward local protocols, and its major sources of variance. Methods: Fourteen tracers segmented 10 Alzheimer's Disease Neuroimaging Initiative (ADNI) cases scanned at 1.5 T and 3T following local protocols, qualified for segmentation based on the HarP through a standard web-platform and resegmented following the HarP. The five most accurate tracers followed the HarP to segment 15 ADNI cases acquired at three time points on both 1.5 T and 3T. Results: The agreement among tracers was relatively low with the local protocols (absolute left/right ICC 0.44/0.43) and much higher with the HarP (absolute left/right ICC 0.88/0.89). On the larger set of 15 cases, the HarP agreement within (left/right ICC range: 0.94/0.95 to 0.99/0.99) and among tracers (left/right ICC range: 0.89/0.90) was very high. The volume variance due to different tracers was 0.9% of the total, comparing favorably to variance due to scanner manufacturer (1.2), atrophy rates (3.5), hemispheric asymmetry (3.7), field strength (4.4), and significantly smaller than the variance due to atrophy (33.5%, P <.001), and physiological variability (49.2%, P <.001). Conclusions: The HarP has high measurement stability compared with local segmentation protocols, and good reproducibility within and among human tracers. Hippocampi segmented with the HarP can be used as a reference for the qualification of human tracers and automated segmentation algorithms.

Original language	English
Journal	Alzheimer's & Dementia
Volume	11
Issue number	2
Pages (from-to)	111-125
Number of pages	15
ISSN	1552-5260
DOIs	https://doi.org/10.1016/j.jalz.2014.05.1756
Publication status	Published - Feb 2015

Keywords

Aged
Alzheimer Disease
Atrophy
Female
Functional Laterality
Hippocampus
Humans
Image Processing, Computer-Assisted
Imaging, Three-Dimensional
Internet
Magnetic Resonance Imaging
Male
Middle Aged
Neuroimaging
Organ Size
Reproducibility of Results

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jalz.2014.05.1756

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Frisoni, G. B., Jack, C. R., Bocchetta, M., Bauer, C., Frederiksen, K. S., Liu, Y., Preboske, G., Swihart, T., Blair, M., Cavedo, E., Grothe, M. J., Lanfredi, M., Martinez, O., Nishikawa, M., Portegies, M., Stoub, T., Ward, C., Apostolova, L. G., Ganzola, R., ... EADC-ADNI Working Group on The Harmonized Protocol for Manual Hippocampal Volumetry and for the Alzheimer's Disease Neuroimaging Initiative (2015). The EADC-ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance: Evidence of validity. Alzheimer's & Dementia, 11(2), 111-125. https://doi.org/10.1016/j.jalz.2014.05.1756

Frisoni, GB, Jack, CR, Bocchetta, M, Bauer, C, Frederiksen, KS, Liu, Y, Preboske, G, Swihart, T, Blair, M, Cavedo, E, Grothe, MJ, Lanfredi, M, Martinez, O, Nishikawa, M, Portegies, M, Stoub, T, Ward, C, Apostolova, LG, Ganzola, R, Wolf, D, Barkhof, F, Bartzokis, G, DeCarli, C, Csernansky, JG, deToledo-Morrell, L, Geerlings, MI, Kaye, J, Killiany, RJ, Lehéricy, S, Matsuda, H, O'Brien, J, Silbert, LC, Scheltens, P, Soininen, H, Teipel, S, Waldemar, G, Fellgiebel, A, Barnes, J, Firbank, M, Gerritsen, L, Henneman, W, Malykhin, N, Pruessner, JC, Wang, L, Watson, C, Wolf, H, deLeon, M, Pantel, J, Ferrari, C, Bosco, P & EADC-ADNI Working Group on The Harmonized Protocol for Manual Hippocampal Volumetry and for the Alzheimer's Disease Neuroimaging Initiative 2015, 'The EADC-ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance: Evidence of validity', Alzheimer's & Dementia, vol. 11, no. 2, pp. 111-125. https://doi.org/10.1016/j.jalz.2014.05.1756

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title = "The EADC-ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance: Evidence of validity",

abstract = "Background: An international Delphi panel has defined a harmonized protocol (HarP) for the manual segmentation of the hippocampus on MR. The aim of this study is to study the concurrent validity of the HarP toward local protocols, and its major sources of variance. Methods: Fourteen tracers segmented 10 Alzheimer's Disease Neuroimaging Initiative (ADNI) cases scanned at 1.5 T and 3T following local protocols, qualified for segmentation based on the HarP through a standard web-platform and resegmented following the HarP. The five most accurate tracers followed the HarP to segment 15 ADNI cases acquired at three time points on both 1.5 T and 3T. Results: The agreement among tracers was relatively low with the local protocols (absolute left/right ICC 0.44/0.43) and much higher with the HarP (absolute left/right ICC 0.88/0.89). On the larger set of 15 cases, the HarP agreement within (left/right ICC range: 0.94/0.95 to 0.99/0.99) and among tracers (left/right ICC range: 0.89/0.90) was very high. The volume variance due to different tracers was 0.9% of the total, comparing favorably to variance due to scanner manufacturer (1.2), atrophy rates (3.5), hemispheric asymmetry (3.7), field strength (4.4), and significantly smaller than the variance due to atrophy (33.5%, P <.001), and physiological variability (49.2%, P <.001). Conclusions: The HarP has high measurement stability compared with local segmentation protocols, and good reproducibility within and among human tracers. Hippocampi segmented with the HarP can be used as a reference for the qualification of human tracers and automated segmentation algorithms.",

keywords = "Aged, Alzheimer Disease, Atrophy, Female, Functional Laterality, Hippocampus, Humans, Image Processing, Computer-Assisted, Imaging, Three-Dimensional, Internet, Magnetic Resonance Imaging, Male, Middle Aged, Neuroimaging, Organ Size, Reproducibility of Results",

author = "Frisoni, {Giovanni B} and Jack, {Clifford R} and Martina Bocchetta and Corinna Bauer and Frederiksen, {Kristian S} and Yawu Liu and Gregory Preboske and Tim Swihart and Melanie Blair and Enrica Cavedo and Grothe, {Michel J} and Mariangela Lanfredi and Oliver Martinez and Masami Nishikawa and Marileen Portegies and Travis Stoub and Chadwich Ward and Apostolova, {Liana G} and Rossana Ganzola and Dominik Wolf and Frederik Barkhof and George Bartzokis and Charles DeCarli and Csernansky, {John G} and Leyla deToledo-Morrell and Geerlings, {Mirjam I} and Jeffrey Kaye and Killiany, {Ronald J} and Stephane Leh{\'e}ricy and Hiroshi Matsuda and John O'Brien and Silbert, {Lisa C} and Philip Scheltens and Hilkka Soininen and Stefan Teipel and Gunhild Waldemar and Andreas Fellgiebel and Josephine Barnes and Michael Firbank and Lotte Gerritsen and Wouter Henneman and Nikolai Malykhin and Pruessner, {Jens C} and Lei Wang and Craig Watson and Henrike Wolf and Mony deLeon and Johannes Pantel and Clarissa Ferrari and Paolo Bosco and {EADC-ADNI Working Group on The Harmonized Protocol for Manual Hippocampal Volumetry and for the Alzheimer's Disease Neuroimaging Initiative}",

year = "2015",

month = feb,

doi = "10.1016/j.jalz.2014.05.1756",

language = "English",

volume = "11",

pages = "111--125",

journal = "Alzheimer's & Dementia",

issn = "1552-5260",

publisher = "Elsevier",

number = "2",

}

TY - JOUR

T1 - The EADC-ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance

T2 - Evidence of validity

AU - Frisoni, Giovanni B

AU - Jack, Clifford R

AU - Bocchetta, Martina

AU - Bauer, Corinna

AU - Frederiksen, Kristian S

AU - Liu, Yawu

AU - Preboske, Gregory

AU - Swihart, Tim

AU - Blair, Melanie

AU - Cavedo, Enrica

AU - Grothe, Michel J

AU - Lanfredi, Mariangela

AU - Martinez, Oliver

AU - Nishikawa, Masami

AU - Portegies, Marileen

AU - Stoub, Travis

AU - Ward, Chadwich

AU - Apostolova, Liana G

AU - Ganzola, Rossana

AU - Wolf, Dominik

AU - Barkhof, Frederik

AU - Bartzokis, George

AU - DeCarli, Charles

AU - Csernansky, John G

AU - deToledo-Morrell, Leyla

AU - Geerlings, Mirjam I

AU - Kaye, Jeffrey

AU - Killiany, Ronald J

AU - Lehéricy, Stephane

AU - Matsuda, Hiroshi

AU - O'Brien, John

AU - Silbert, Lisa C

AU - Scheltens, Philip

AU - Soininen, Hilkka

AU - Teipel, Stefan

AU - Waldemar, Gunhild

AU - Fellgiebel, Andreas

AU - Barnes, Josephine

AU - Firbank, Michael

AU - Gerritsen, Lotte

AU - Henneman, Wouter

AU - Malykhin, Nikolai

AU - Pruessner, Jens C

AU - Wang, Lei

AU - Watson, Craig

AU - Wolf, Henrike

AU - deLeon, Mony

AU - Pantel, Johannes

AU - Ferrari, Clarissa

AU - Bosco, Paolo

AU - EADC-ADNI Working Group on The Harmonized Protocol for Manual Hippocampal Volumetry and for the Alzheimer's Disease Neuroimaging Initiative

PY - 2015/2

Y1 - 2015/2

N2 - Background: An international Delphi panel has defined a harmonized protocol (HarP) for the manual segmentation of the hippocampus on MR. The aim of this study is to study the concurrent validity of the HarP toward local protocols, and its major sources of variance. Methods: Fourteen tracers segmented 10 Alzheimer's Disease Neuroimaging Initiative (ADNI) cases scanned at 1.5 T and 3T following local protocols, qualified for segmentation based on the HarP through a standard web-platform and resegmented following the HarP. The five most accurate tracers followed the HarP to segment 15 ADNI cases acquired at three time points on both 1.5 T and 3T. Results: The agreement among tracers was relatively low with the local protocols (absolute left/right ICC 0.44/0.43) and much higher with the HarP (absolute left/right ICC 0.88/0.89). On the larger set of 15 cases, the HarP agreement within (left/right ICC range: 0.94/0.95 to 0.99/0.99) and among tracers (left/right ICC range: 0.89/0.90) was very high. The volume variance due to different tracers was 0.9% of the total, comparing favorably to variance due to scanner manufacturer (1.2), atrophy rates (3.5), hemispheric asymmetry (3.7), field strength (4.4), and significantly smaller than the variance due to atrophy (33.5%, P <.001), and physiological variability (49.2%, P <.001). Conclusions: The HarP has high measurement stability compared with local segmentation protocols, and good reproducibility within and among human tracers. Hippocampi segmented with the HarP can be used as a reference for the qualification of human tracers and automated segmentation algorithms.

AB - Background: An international Delphi panel has defined a harmonized protocol (HarP) for the manual segmentation of the hippocampus on MR. The aim of this study is to study the concurrent validity of the HarP toward local protocols, and its major sources of variance. Methods: Fourteen tracers segmented 10 Alzheimer's Disease Neuroimaging Initiative (ADNI) cases scanned at 1.5 T and 3T following local protocols, qualified for segmentation based on the HarP through a standard web-platform and resegmented following the HarP. The five most accurate tracers followed the HarP to segment 15 ADNI cases acquired at three time points on both 1.5 T and 3T. Results: The agreement among tracers was relatively low with the local protocols (absolute left/right ICC 0.44/0.43) and much higher with the HarP (absolute left/right ICC 0.88/0.89). On the larger set of 15 cases, the HarP agreement within (left/right ICC range: 0.94/0.95 to 0.99/0.99) and among tracers (left/right ICC range: 0.89/0.90) was very high. The volume variance due to different tracers was 0.9% of the total, comparing favorably to variance due to scanner manufacturer (1.2), atrophy rates (3.5), hemispheric asymmetry (3.7), field strength (4.4), and significantly smaller than the variance due to atrophy (33.5%, P <.001), and physiological variability (49.2%, P <.001). Conclusions: The HarP has high measurement stability compared with local segmentation protocols, and good reproducibility within and among human tracers. Hippocampi segmented with the HarP can be used as a reference for the qualification of human tracers and automated segmentation algorithms.

KW - Aged

KW - Alzheimer Disease

KW - Atrophy

KW - Female

KW - Functional Laterality

KW - Hippocampus

KW - Humans

KW - Image Processing, Computer-Assisted

KW - Imaging, Three-Dimensional

KW - Internet

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Neuroimaging

KW - Organ Size

KW - Reproducibility of Results

U2 - 10.1016/j.jalz.2014.05.1756

DO - 10.1016/j.jalz.2014.05.1756

M3 - Journal article

C2 - 25267715

SN - 1552-5260

VL - 11

SP - 111

EP - 125

JO - Alzheimer's & Dementia

JF - Alzheimer's & Dementia

IS - 2

ER -

The EADC-ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance: Evidence of validity

Abstract

Keywords

UN SDGs

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