The DNA-damage response in human biology and disease

TY - JOUR

T1 - The DNA-damage response in human biology and disease

AU - Jackson, Stephen P

AU - Bartek, Jiri

N1 - Keywords: Cell Cycle; DNA Damage; DNA Repair; Disease; Genome, Human; Humans; Signal Transduction

PY - 2009

Y1 - 2009

N2 - The prime objective for every life form is to deliver its genetic material, intact and unchanged, to the next generation. This must be achieved despite constant assaults by endogenous and environmental agents on the DNA. To counter this threat, life has evolved several systems to detect DNA damage, signal its presence and mediate its repair. Such responses, which have an impact on a wide range of cellular events, are biologically significant because they prevent diverse human diseases. Our improving understanding of DNA-damage responses is providing new avenues for disease management.

AB - The prime objective for every life form is to deliver its genetic material, intact and unchanged, to the next generation. This must be achieved despite constant assaults by endogenous and environmental agents on the DNA. To counter this threat, life has evolved several systems to detect DNA damage, signal its presence and mediate its repair. Such responses, which have an impact on a wide range of cellular events, are biologically significant because they prevent diverse human diseases. Our improving understanding of DNA-damage responses is providing new avenues for disease management.

U2 - 10.1038/nature08467

DO - 10.1038/nature08467

M3 - Journal article

C2 - 19847258

SN - 0028-0836

VL - 461

SP - 1071

EP - 1078

JO - Nature

JF - Nature

IS - 7267

ER -