The Dissolution of Double Holliday Junctions

Anna H Bizard; Ian D Hickson

doi:10.1101/cshperspect.a016477

The Dissolution of Double Holliday Junctions

94 Citations (Scopus)

Abstract

Double Holliday junctions (dHJS) are important intermediates of homologous recombination. The separate junctions can each be cleaved by DNA structure-selective endonucleases known as Holliday junction resolvases. Alternatively, double Holliday junctions can be processed by a reaction known as "double Holliday junction dissolution." This reaction requires the cooperative action ofaso-called "dissolvasome" comprisingaHolliday junction branch migration enzyme (Sgs1/BLM RecQ helicase) and a type IA topoisomerase (Top3/ TopoIIIa) in complex with its OB (oligonucleotide/oligosaccharide binding) fold containing accessory factor (Rmi1). This review details our current knowledge of the dissolution process and the players involved in catalyzing this mechanistically complex means of completing homologous recombination reactions.

Original language	English
Article number	a016477
Journal	Cold Spring Harbor perspectives in biology
Volume	6
Pages (from-to)	1-16
Number of pages	16
ISSN	1943-0264
DOIs	https://doi.org/10.1101/cshperspect.a016477
Publication status	Published - 1 Jul 2014

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abstract = "Double Holliday junctions (dHJS) are important intermediates of homologous recombination. The separate junctions can each be cleaved by DNA structure-selective endonucleases known as Holliday junction resolvases. Alternatively, double Holliday junctions can be processed by a reaction known as {"}double Holliday junction dissolution.{"} This reaction requires the cooperative action ofaso-called {"}dissolvasome{"} comprisingaHolliday junction branch migration enzyme (Sgs1/BLM RecQ helicase) and a type IA topoisomerase (Top3/ TopoIIIa) in complex with its OB (oligonucleotide/oligosaccharide binding) fold containing accessory factor (Rmi1). This review details our current knowledge of the dissolution process and the players involved in catalyzing this mechanistically complex means of completing homologous recombination reactions.",

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AU - Bizard, Anna H

AU - Hickson, Ian D

PY - 2014/7/1

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N2 - Double Holliday junctions (dHJS) are important intermediates of homologous recombination. The separate junctions can each be cleaved by DNA structure-selective endonucleases known as Holliday junction resolvases. Alternatively, double Holliday junctions can be processed by a reaction known as "double Holliday junction dissolution." This reaction requires the cooperative action ofaso-called "dissolvasome" comprisingaHolliday junction branch migration enzyme (Sgs1/BLM RecQ helicase) and a type IA topoisomerase (Top3/ TopoIIIa) in complex with its OB (oligonucleotide/oligosaccharide binding) fold containing accessory factor (Rmi1). This review details our current knowledge of the dissolution process and the players involved in catalyzing this mechanistically complex means of completing homologous recombination reactions.

AB - Double Holliday junctions (dHJS) are important intermediates of homologous recombination. The separate junctions can each be cleaved by DNA structure-selective endonucleases known as Holliday junction resolvases. Alternatively, double Holliday junctions can be processed by a reaction known as "double Holliday junction dissolution." This reaction requires the cooperative action ofaso-called "dissolvasome" comprisingaHolliday junction branch migration enzyme (Sgs1/BLM RecQ helicase) and a type IA topoisomerase (Top3/ TopoIIIa) in complex with its OB (oligonucleotide/oligosaccharide binding) fold containing accessory factor (Rmi1). This review details our current knowledge of the dissolution process and the players involved in catalyzing this mechanistically complex means of completing homologous recombination reactions.

U2 - 10.1101/cshperspect.a016477

DO - 10.1101/cshperspect.a016477

M3 - Review

C2 - 24984776

SN - 1943-0264

VL - 6

SP - 1

EP - 16

JO - Cold Spring Harbor Perspectives in Biology

JF - Cold Spring Harbor Perspectives in Biology

M1 - a016477

ER -

The Dissolution of Double Holliday Junctions

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