The Danish PET/depression project: clinical symptoms and cerebral blood flow. A regions-of-interest analysis.

P Videbech; B Ravnkilde; T H Pedersen; H Hartvig; A Egander; K Clemmensen; N A Rasmussen; Flemming Andersen; A Gjedde; R Rosenberg

The Danish PET/depression project: clinical symptoms and cerebral blood flow. A regions-of-interest analysis.

P Videbech, B Ravnkilde, T H Pedersen, H Hartvig, A Egander, K Clemmensen, N A Rasmussen, Flemming Andersen, A Gjedde, R Rosenberg

123 Citations (Scopus)

Abstract

OBJECTIVE: We wanted to explore associations between clinical symptoms of depression and the blood flow to specific regions of the brain. Furthermore, we wanted to compare the regions-of-interest (ROI) method with the functions-of-interest (FOI) approach. METHOD: The resting blood flow to 42 ROI in the brain was obtained with positron emission tomography (PET) imaging in 42 representative in-patients with major depression and 47 matched healthy controls. RESULTS: The patients had increased blood flow to hippocampus, cerebellum, anterior cingulate gyrus, and the basal ganglia. A strong negative correlation was found between the degree of psychomotor retardation of the patients and the blood flow to the dorsolateral and supraorbital prefrontal cortices. The total Hamilton score was correlated with the blood flow to the hippocampus. CONCLUSION: Our findings support the notion that depressed patients have disturbances in the loops connecting the frontal lobes, limbic system, basal ganglia, and cerebellum.

Original language	English
Journal	Acta Psychiatrica Scandinavica
Volume	106
Issue number	1
Pages (from-to)	35-44
Number of pages	9
ISSN	0001-690X
Publication status	Published - 2002
Externally published	Yes

Cite this

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title = "The Danish PET/depression project: clinical symptoms and cerebral blood flow. A regions-of-interest analysis.",

abstract = "OBJECTIVE: We wanted to explore associations between clinical symptoms of depression and the blood flow to specific regions of the brain. Furthermore, we wanted to compare the regions-of-interest (ROI) method with the functions-of-interest (FOI) approach. METHOD: The resting blood flow to 42 ROI in the brain was obtained with positron emission tomography (PET) imaging in 42 representative in-patients with major depression and 47 matched healthy controls. RESULTS: The patients had increased blood flow to hippocampus, cerebellum, anterior cingulate gyrus, and the basal ganglia. A strong negative correlation was found between the degree of psychomotor retardation of the patients and the blood flow to the dorsolateral and supraorbital prefrontal cortices. The total Hamilton score was correlated with the blood flow to the hippocampus. CONCLUSION: Our findings support the notion that depressed patients have disturbances in the loops connecting the frontal lobes, limbic system, basal ganglia, and cerebellum.",

author = "P Videbech and B Ravnkilde and Pedersen, {T H} and H Hartvig and A Egander and K Clemmensen and Rasmussen, {N A} and Flemming Andersen and A Gjedde and R Rosenberg",

year = "2002",

language = "English",

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journal = "Acta Psychiatrica Scandinavica",

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TY - JOUR

T1 - The Danish PET/depression project: clinical symptoms and cerebral blood flow. A regions-of-interest analysis.

AU - Videbech, P

AU - Ravnkilde, B

AU - Pedersen, T H

AU - Hartvig, H

AU - Egander, A

AU - Clemmensen, K

AU - Rasmussen, N A

AU - Andersen, Flemming

AU - Gjedde, A

AU - Rosenberg, R

PY - 2002

Y1 - 2002

N2 - OBJECTIVE: We wanted to explore associations between clinical symptoms of depression and the blood flow to specific regions of the brain. Furthermore, we wanted to compare the regions-of-interest (ROI) method with the functions-of-interest (FOI) approach. METHOD: The resting blood flow to 42 ROI in the brain was obtained with positron emission tomography (PET) imaging in 42 representative in-patients with major depression and 47 matched healthy controls. RESULTS: The patients had increased blood flow to hippocampus, cerebellum, anterior cingulate gyrus, and the basal ganglia. A strong negative correlation was found between the degree of psychomotor retardation of the patients and the blood flow to the dorsolateral and supraorbital prefrontal cortices. The total Hamilton score was correlated with the blood flow to the hippocampus. CONCLUSION: Our findings support the notion that depressed patients have disturbances in the loops connecting the frontal lobes, limbic system, basal ganglia, and cerebellum.

AB - OBJECTIVE: We wanted to explore associations between clinical symptoms of depression and the blood flow to specific regions of the brain. Furthermore, we wanted to compare the regions-of-interest (ROI) method with the functions-of-interest (FOI) approach. METHOD: The resting blood flow to 42 ROI in the brain was obtained with positron emission tomography (PET) imaging in 42 representative in-patients with major depression and 47 matched healthy controls. RESULTS: The patients had increased blood flow to hippocampus, cerebellum, anterior cingulate gyrus, and the basal ganglia. A strong negative correlation was found between the degree of psychomotor retardation of the patients and the blood flow to the dorsolateral and supraorbital prefrontal cortices. The total Hamilton score was correlated with the blood flow to the hippocampus. CONCLUSION: Our findings support the notion that depressed patients have disturbances in the loops connecting the frontal lobes, limbic system, basal ganglia, and cerebellum.

M3 - Journal article

C2 - 12100346

SN - 0001-690X

VL - 106

SP - 35

EP - 44

JO - Acta Psychiatrica Scandinavica

JF - Acta Psychiatrica Scandinavica

IS - 1

ER -

The Danish PET/depression project: clinical symptoms and cerebral blood flow. A regions-of-interest analysis.

Abstract

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