The Danish PEP Registry: Experience with the use of post-exposure prophylaxis following blood exposure to HIV from 1999-2012

Suzanne Lunding; Terese L Katzenstein; Gitte Kronborg; Merete Storgaard; Court Pedersen; Birgitte Mørn; Jens Å Lindberg; Thit M Kronborg; Janne Jensen

doi:10.3109/23744235.2015.1103896

The Danish PEP Registry: Experience with the use of post-exposure prophylaxis following blood exposure to HIV from 1999-2012

Suzanne Lunding, Terese L Katzenstein, Gitte Kronborg, Merete Storgaard, Court Pedersen, Birgitte Mørn, Jens Å Lindberg, Thit M Kronborg, Janne Jensen

Department of Clinical Medicine

3 Citations (Scopus)

Abstract

BACKGROUND: The risk of occupational exposures to blood cannot be eliminated completely and access to post-exposure prophylaxis (PEP) to prevent HIV transmission is important. However, PEP administration has been associated with frequent adverse effects, low compliance and difficulties to ensure a proper risk assessment. This nationwide study describes 14 years of experience with the use of PEP following blood exposure in Denmark.

METHODS: A descriptive study of all PEP cases following non-sexual exposure to HIV in Denmark from 1999-2012.

RESULTS: A total of 411 cases of PEP were described. There was a mean of 29.4 cases/year, increasing from 23 cases in 1999 to 49 cases in 2005 and then decreasing to 16 cases in 2012. Overall 67.2% of source patients were known to be HIV-positive at the time of PEP initiation, with no significant change over time. The median time to initiation of PEP was 2.5 h (0.15-28.5) following occupational exposure. Adverse effects were reported by 50.9% with no significant difference according to PEP regimen. In 85.1% of cases with available data, either a full course of PEP was completed or PEP was stopped because the source was tested HIV-negative. Only 6.6% stopped PEP early due to adverse effects.

CONCLUSIONS: PEP in Denmark is generally prescribed according to the guidelines and the annual number of cases has declined since 2005. Adverse effects were common regardless of PEP regimens used and new drug regimens should be considered.

Original language	English
Journal	Infectious Diseases
Volume	48
Issue number	3
Pages (from-to)	195-200
Number of pages	6
ISSN	2374-4235
DOIs	https://doi.org/10.3109/23744235.2015.1103896
Publication status	Published - 2016

Keywords

Adolescent
Adult
Aged
Anti-HIV Agents
Blood-Borne Pathogens
Child
Denmark
Female
Guideline Adherence
HIV
HIV Infections
Health Personnel
Hepatitis, Viral, Human
Humans
Infectious Disease Transmission, Patient-to-Professional
Male
Middle Aged
Occupational Exposure
Post-Exposure Prophylaxis
Practice Guidelines as Topic
Registries
Risk Factors
Young Adult
Journal Article

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3109/23744235.2015.1103896

Cite this

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title = "The Danish PEP Registry: Experience with the use of post-exposure prophylaxis following blood exposure to HIV from 1999-2012",

abstract = "BACKGROUND: The risk of occupational exposures to blood cannot be eliminated completely and access to post-exposure prophylaxis (PEP) to prevent HIV transmission is important. However, PEP administration has been associated with frequent adverse effects, low compliance and difficulties to ensure a proper risk assessment. This nationwide study describes 14 years of experience with the use of PEP following blood exposure in Denmark.METHODS: A descriptive study of all PEP cases following non-sexual exposure to HIV in Denmark from 1999-2012.RESULTS: A total of 411 cases of PEP were described. There was a mean of 29.4 cases/year, increasing from 23 cases in 1999 to 49 cases in 2005 and then decreasing to 16 cases in 2012. Overall 67.2% of source patients were known to be HIV-positive at the time of PEP initiation, with no significant change over time. The median time to initiation of PEP was 2.5 h (0.15-28.5) following occupational exposure. Adverse effects were reported by 50.9% with no significant difference according to PEP regimen. In 85.1% of cases with available data, either a full course of PEP was completed or PEP was stopped because the source was tested HIV-negative. Only 6.6% stopped PEP early due to adverse effects.CONCLUSIONS: PEP in Denmark is generally prescribed according to the guidelines and the annual number of cases has declined since 2005. Adverse effects were common regardless of PEP regimens used and new drug regimens should be considered.",

keywords = "Adolescent, Adult, Aged, Anti-HIV Agents, Blood-Borne Pathogens, Child, Denmark, Female, Guideline Adherence, HIV, HIV Infections, Health Personnel, Hepatitis, Viral, Human, Humans, Infectious Disease Transmission, Patient-to-Professional, Male, Middle Aged, Occupational Exposure, Post-Exposure Prophylaxis, Practice Guidelines as Topic, Registries, Risk Factors, Young Adult, Journal Article",

author = "Suzanne Lunding and Katzenstein, {Terese L} and Gitte Kronborg and Merete Storgaard and Court Pedersen and Birgitte M{\o}rn and Lindberg, {Jens {\AA}} and Kronborg, {Thit M} and Janne Jensen",

year = "2016",

doi = "10.3109/23744235.2015.1103896",

language = "English",

volume = "48",

pages = "195--200",

journal = "Infectious Diseases",

issn = "2374-4235",

publisher = "Taylor & Francis",

number = "3",

}

TY - JOUR

T1 - The Danish PEP Registry

T2 - Experience with the use of post-exposure prophylaxis following blood exposure to HIV from 1999-2012

AU - Lunding, Suzanne

AU - Katzenstein, Terese L

AU - Kronborg, Gitte

AU - Storgaard, Merete

AU - Pedersen, Court

AU - Mørn, Birgitte

AU - Lindberg, Jens Å

AU - Kronborg, Thit M

AU - Jensen, Janne

PY - 2016

Y1 - 2016

N2 - BACKGROUND: The risk of occupational exposures to blood cannot be eliminated completely and access to post-exposure prophylaxis (PEP) to prevent HIV transmission is important. However, PEP administration has been associated with frequent adverse effects, low compliance and difficulties to ensure a proper risk assessment. This nationwide study describes 14 years of experience with the use of PEP following blood exposure in Denmark.METHODS: A descriptive study of all PEP cases following non-sexual exposure to HIV in Denmark from 1999-2012.RESULTS: A total of 411 cases of PEP were described. There was a mean of 29.4 cases/year, increasing from 23 cases in 1999 to 49 cases in 2005 and then decreasing to 16 cases in 2012. Overall 67.2% of source patients were known to be HIV-positive at the time of PEP initiation, with no significant change over time. The median time to initiation of PEP was 2.5 h (0.15-28.5) following occupational exposure. Adverse effects were reported by 50.9% with no significant difference according to PEP regimen. In 85.1% of cases with available data, either a full course of PEP was completed or PEP was stopped because the source was tested HIV-negative. Only 6.6% stopped PEP early due to adverse effects.CONCLUSIONS: PEP in Denmark is generally prescribed according to the guidelines and the annual number of cases has declined since 2005. Adverse effects were common regardless of PEP regimens used and new drug regimens should be considered.

AB - BACKGROUND: The risk of occupational exposures to blood cannot be eliminated completely and access to post-exposure prophylaxis (PEP) to prevent HIV transmission is important. However, PEP administration has been associated with frequent adverse effects, low compliance and difficulties to ensure a proper risk assessment. This nationwide study describes 14 years of experience with the use of PEP following blood exposure in Denmark.METHODS: A descriptive study of all PEP cases following non-sexual exposure to HIV in Denmark from 1999-2012.RESULTS: A total of 411 cases of PEP were described. There was a mean of 29.4 cases/year, increasing from 23 cases in 1999 to 49 cases in 2005 and then decreasing to 16 cases in 2012. Overall 67.2% of source patients were known to be HIV-positive at the time of PEP initiation, with no significant change over time. The median time to initiation of PEP was 2.5 h (0.15-28.5) following occupational exposure. Adverse effects were reported by 50.9% with no significant difference according to PEP regimen. In 85.1% of cases with available data, either a full course of PEP was completed or PEP was stopped because the source was tested HIV-negative. Only 6.6% stopped PEP early due to adverse effects.CONCLUSIONS: PEP in Denmark is generally prescribed according to the guidelines and the annual number of cases has declined since 2005. Adverse effects were common regardless of PEP regimens used and new drug regimens should be considered.

KW - Adolescent

KW - Adult

KW - Aged

KW - Anti-HIV Agents

KW - Blood-Borne Pathogens

KW - Child

KW - Denmark

KW - Female

KW - Guideline Adherence

KW - HIV

KW - HIV Infections

KW - Health Personnel

KW - Hepatitis, Viral, Human

KW - Humans

KW - Infectious Disease Transmission, Patient-to-Professional

KW - Male

KW - Middle Aged

KW - Occupational Exposure

KW - Post-Exposure Prophylaxis

KW - Practice Guidelines as Topic

KW - Registries

KW - Risk Factors

KW - Young Adult

KW - Journal Article

U2 - 10.3109/23744235.2015.1103896

DO - 10.3109/23744235.2015.1103896

M3 - Journal article

C2 - 26529586

SN - 2374-4235

VL - 48

SP - 195

EP - 200

JO - Infectious Diseases

JF - Infectious Diseases

IS - 3

ER -

The Danish PEP Registry: Experience with the use of post-exposure prophylaxis following blood exposure to HIV from 1999-2012

Abstract

Keywords

UN SDGs

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