The D-vitamin metabolite 1,25(OH)2 D in serum is associated with disease activity and Anti-Citrullinated Protein Antibodies in active and treatment naïve, early Rheumatoid Arthritis Patients

Mette Herly; Kristian Stengaard-Pedersen; Peter Vestergaard; Mikkel Østergaard; Peter Junker; Merete L Hetland; Kim Hørslev-Petersen; Torkell Ellingsen

doi:10.1111/sji.12704

The D-vitamin metabolite 1,25(OH)₂ D in serum is associated with disease activity and Anti-Citrullinated Protein Antibodies in active and treatment naïve, early Rheumatoid Arthritis Patients

Mette Herly, Kristian Stengaard-Pedersen, Peter Vestergaard, Mikkel Østergaard, Peter Junker, Merete L Hetland, Kim Hørslev-Petersen, Torkell Ellingsen

Department of Clinical Medicine

8 Citations (Scopus)

Abstract

RATIONALE: Sufficient levels of vitamin D seem to be essential for proper immune function, and low levels might be associated to disease activity in Rheumatoid Arthritis (RA). Most studies investigate only 25OHD and not the physiologically active vitamin D metabolite, 1,25(OH)2 D.

OBJECTIVE: To investigate associations between serum level of vitamin D metabolites and disease activity parameters in 160 inflammatory active and treatment naïve early RA patients. Serum level of vitamin D metabolites (25OHD2 , 25OHD3 and 1,25(OH)2 D) was measured by isotope dilution mass spectrometry and radio-immunoassays at baseline. Disease characteristics were gender, number of tender joints, number of swollen joints, DAS28-CRP, HAQ, VAS-scores, CRP, erosive status (Total Sharp Score; TSS), ACPA and IgM-RF-status. Associations were evaluated using Spearman's and Wilcoxon rank-sum tests. The study was registered in clinical trials; trial registration number: NCT00209859.

FINDINGS: Statistically significant inverse associations were found between the active metabolite 1,25(OH)2 D and DAS28-CRP (P = 0.004, rho = -0.23), HAQ (P = 0.005, rho = -0.22), CRP (P = 0.001, rho = -0.25), VASpatient-pain (P = 0.008, rho = -0.21), and a positive association was found to ACPA-status (P = 0.04).

CONCLUSION: The vitamin D metabolite 1,25(OH)2 D was inversely associated with disease activity and positively associated with ACPA in treatment naïve and inflammatory active early RA. The results indicate that in RA, both the degree of inflammatory activity, and the diagnostic sensitivity and specificity might affect-or might be affected by the level of vitamin 1,25(OH)2 D.

Original language	English
Article number	e12704
Journal	Scandinavian Journal of Immunology
Volume	88
Issue number	3
Number of pages	9
ISSN	0300-9475
DOIs	https://doi.org/10.1111/sji.12704
Publication status	Published - Sept 2018

Keywords

Adult
Aged
Anti-Citrullinated Protein Antibodies/blood
Antirheumatic Agents/therapeutic use
Arthritis, Rheumatoid/diagnosis
Biomarkers/blood
Calcitriol/blood
Disease Progression
Ergocalciferols/blood
Female
Humans
Immunity, Humoral
Male
Middle Aged
Severity of Illness Index
Vitamin D/analogs & derivatives
Young Adult

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Herly, M., Stengaard-Pedersen, K., Vestergaard, P., Østergaard, M., Junker, P., Hetland, M. L., Hørslev-Petersen, K., & Ellingsen, T. (2018). The D-vitamin metabolite 1,25(OH)₂ D in serum is associated with disease activity and Anti-Citrullinated Protein Antibodies in active and treatment naïve, early Rheumatoid Arthritis Patients. Scandinavian Journal of Immunology, 88(3), Article e12704. https://doi.org/10.1111/sji.12704

The D-vitamin metabolite 1,25(OH)₂ D in serum is associated with disease activity and Anti-Citrullinated Protein Antibodies in active and treatment naïve, early Rheumatoid Arthritis Patients. / Herly, Mette; Stengaard-Pedersen, Kristian; Vestergaard, Peter et al.
In: Scandinavian Journal of Immunology, Vol. 88, No. 3, e12704, 09.2018.

Research output: Contribution to journal › Journal article › Research › peer-review

Herly, M, Stengaard-Pedersen, K, Vestergaard, P, Østergaard, M, Junker, P, Hetland, ML, Hørslev-Petersen, K & Ellingsen, T 2018, 'The D-vitamin metabolite 1,25(OH)₂ D in serum is associated with disease activity and Anti-Citrullinated Protein Antibodies in active and treatment naïve, early Rheumatoid Arthritis Patients', Scandinavian Journal of Immunology, vol. 88, no. 3, e12704. https://doi.org/10.1111/sji.12704

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title = "The D-vitamin metabolite 1,25(OH)2 D in serum is associated with disease activity and Anti-Citrullinated Protein Antibodies in active and treatment na{\"i}ve, early Rheumatoid Arthritis Patients",

abstract = "RATIONALE: Sufficient levels of vitamin D seem to be essential for proper immune function, and low levels might be associated to disease activity in Rheumatoid Arthritis (RA). Most studies investigate only 25OHD and not the physiologically active vitamin D metabolite, 1,25(OH)2 D.OBJECTIVE: To investigate associations between serum level of vitamin D metabolites and disease activity parameters in 160 inflammatory active and treatment na{\"i}ve early RA patients. Serum level of vitamin D metabolites (25OHD2 , 25OHD3 and 1,25(OH)2 D) was measured by isotope dilution mass spectrometry and radio-immunoassays at baseline. Disease characteristics were gender, number of tender joints, number of swollen joints, DAS28-CRP, HAQ, VAS-scores, CRP, erosive status (Total Sharp Score; TSS), ACPA and IgM-RF-status. Associations were evaluated using Spearman's and Wilcoxon rank-sum tests. The study was registered in clinical trials; trial registration number: NCT00209859.FINDINGS: Statistically significant inverse associations were found between the active metabolite 1,25(OH)2 D and DAS28-CRP (P = 0.004, rho = -0.23), HAQ (P = 0.005, rho = -0.22), CRP (P = 0.001, rho = -0.25), VASpatient-pain (P = 0.008, rho = -0.21), and a positive association was found to ACPA-status (P = 0.04).CONCLUSION: The vitamin D metabolite 1,25(OH)2 D was inversely associated with disease activity and positively associated with ACPA in treatment na{\"i}ve and inflammatory active early RA. The results indicate that in RA, both the degree of inflammatory activity, and the diagnostic sensitivity and specificity might affect-or might be affected by the level of vitamin 1,25(OH)2 D.",

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T1 - The D-vitamin metabolite 1,25(OH)2 D in serum is associated with disease activity and Anti-Citrullinated Protein Antibodies in active and treatment naïve, early Rheumatoid Arthritis Patients

AU - Herly, Mette

AU - Stengaard-Pedersen, Kristian

AU - Vestergaard, Peter

AU - Østergaard, Mikkel

AU - Junker, Peter

AU - Hetland, Merete L

AU - Hørslev-Petersen, Kim

AU - Ellingsen, Torkell

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Y1 - 2018/9

N2 - RATIONALE: Sufficient levels of vitamin D seem to be essential for proper immune function, and low levels might be associated to disease activity in Rheumatoid Arthritis (RA). Most studies investigate only 25OHD and not the physiologically active vitamin D metabolite, 1,25(OH)2 D.OBJECTIVE: To investigate associations between serum level of vitamin D metabolites and disease activity parameters in 160 inflammatory active and treatment naïve early RA patients. Serum level of vitamin D metabolites (25OHD2 , 25OHD3 and 1,25(OH)2 D) was measured by isotope dilution mass spectrometry and radio-immunoassays at baseline. Disease characteristics were gender, number of tender joints, number of swollen joints, DAS28-CRP, HAQ, VAS-scores, CRP, erosive status (Total Sharp Score; TSS), ACPA and IgM-RF-status. Associations were evaluated using Spearman's and Wilcoxon rank-sum tests. The study was registered in clinical trials; trial registration number: NCT00209859.FINDINGS: Statistically significant inverse associations were found between the active metabolite 1,25(OH)2 D and DAS28-CRP (P = 0.004, rho = -0.23), HAQ (P = 0.005, rho = -0.22), CRP (P = 0.001, rho = -0.25), VASpatient-pain (P = 0.008, rho = -0.21), and a positive association was found to ACPA-status (P = 0.04).CONCLUSION: The vitamin D metabolite 1,25(OH)2 D was inversely associated with disease activity and positively associated with ACPA in treatment naïve and inflammatory active early RA. The results indicate that in RA, both the degree of inflammatory activity, and the diagnostic sensitivity and specificity might affect-or might be affected by the level of vitamin 1,25(OH)2 D.

AB - RATIONALE: Sufficient levels of vitamin D seem to be essential for proper immune function, and low levels might be associated to disease activity in Rheumatoid Arthritis (RA). Most studies investigate only 25OHD and not the physiologically active vitamin D metabolite, 1,25(OH)2 D.OBJECTIVE: To investigate associations between serum level of vitamin D metabolites and disease activity parameters in 160 inflammatory active and treatment naïve early RA patients. Serum level of vitamin D metabolites (25OHD2 , 25OHD3 and 1,25(OH)2 D) was measured by isotope dilution mass spectrometry and radio-immunoassays at baseline. Disease characteristics were gender, number of tender joints, number of swollen joints, DAS28-CRP, HAQ, VAS-scores, CRP, erosive status (Total Sharp Score; TSS), ACPA and IgM-RF-status. Associations were evaluated using Spearman's and Wilcoxon rank-sum tests. The study was registered in clinical trials; trial registration number: NCT00209859.FINDINGS: Statistically significant inverse associations were found between the active metabolite 1,25(OH)2 D and DAS28-CRP (P = 0.004, rho = -0.23), HAQ (P = 0.005, rho = -0.22), CRP (P = 0.001, rho = -0.25), VASpatient-pain (P = 0.008, rho = -0.21), and a positive association was found to ACPA-status (P = 0.04).CONCLUSION: The vitamin D metabolite 1,25(OH)2 D was inversely associated with disease activity and positively associated with ACPA in treatment naïve and inflammatory active early RA. The results indicate that in RA, both the degree of inflammatory activity, and the diagnostic sensitivity and specificity might affect-or might be affected by the level of vitamin 1,25(OH)2 D.

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KW - Aged

KW - Anti-Citrullinated Protein Antibodies/blood

KW - Antirheumatic Agents/therapeutic use

KW - Arthritis, Rheumatoid/diagnosis

KW - Biomarkers/blood

KW - Calcitriol/blood

KW - Disease Progression

KW - Ergocalciferols/blood

KW - Female

KW - Humans

KW - Immunity, Humoral

KW - Male

KW - Middle Aged

KW - Severity of Illness Index

KW - Vitamin D/analogs & derivatives

KW - Young Adult

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DO - 10.1111/sji.12704

M3 - Journal article

C2 - 30048002

SN - 0300-9475

VL - 88

JO - Scandinavian Journal of Immunology

JF - Scandinavian Journal of Immunology

IS - 3

M1 - e12704

ER -