The CMG Helicase Bypasses DNA-Protein Cross-Links to Facilitate Their Repair

Justin L Sparks; Gheorghe Chistol; Alan O. Gao; Markus Räschle; Nicolai B. Larsen; Matthias Mann; Julien P. Duxin; Johannes C. Walter

doi:10.1016/j.cell.2018.10.053

The CMG Helicase Bypasses DNA-Protein Cross-Links to Facilitate Their Repair

Justin L Sparks, Gheorghe Chistol, Alan O. Gao, Markus Räschle, Nicolai B. Larsen, Matthias Mann, Julien P. Duxin, Johannes C. Walter^*

^*Corresponding author for this work

Novo Nordisk Foundation Center for Protein Research

54 Citations (Scopus)

Abstract

A collaboration between helicases ensures that DNA damage in the form of DNA-protein cross-links does not derail replication, helping to preserve genome stability.

Original language	English
Journal	Cell
Volume	176
Issue number	1-2
Pages (from-to)	167-181.e21
Number of pages	36
ISSN	0092-8674
DOIs	https://doi.org/10.1016/j.cell.2018.10.053
Publication status	Published - 10 Jan 2019

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title = "The CMG Helicase Bypasses DNA-Protein Cross-Links to Facilitate Their Repair",

abstract = "A collaboration between helicases ensures that DNA damage in the form of DNA-protein cross-links does not derail replication, helping to preserve genome stability.",

author = "Sparks, {Justin L} and Gheorghe Chistol and Gao, {Alan O.} and Markus R{\"a}schle and Larsen, {Nicolai B.} and Matthias Mann and Duxin, {Julien P.} and Walter, {Johannes C.}",

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T1 - The CMG Helicase Bypasses DNA-Protein Cross-Links to Facilitate Their Repair

AU - Sparks, Justin L

AU - Chistol, Gheorghe

AU - Gao, Alan O.

AU - Räschle, Markus

AU - Larsen, Nicolai B.

AU - Mann, Matthias

AU - Duxin, Julien P.

AU - Walter, Johannes C.

PY - 2019/1/10

Y1 - 2019/1/10

N2 - A collaboration between helicases ensures that DNA damage in the form of DNA-protein cross-links does not derail replication, helping to preserve genome stability.

AB - A collaboration between helicases ensures that DNA damage in the form of DNA-protein cross-links does not derail replication, helping to preserve genome stability.

U2 - 10.1016/j.cell.2018.10.053

DO - 10.1016/j.cell.2018.10.053

M3 - Journal article

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SN - 0092-8674

VL - 176

SP - 167-181.e21

JO - Cell

JF - Cell

IS - 1-2

ER -

The CMG Helicase Bypasses DNA-Protein Cross-Links to Facilitate Their Repair

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