The challenge of preserving cardiorespiratory fitness in physically inactive patients with colon or breast cancer during adjuvant chemotherapy: A randomised feasibility study

Tom Møller; Christian Lillelund; Christina Andersen; Kira Bloomquist; Karl Bang Christensen; Bent Ejlertsen; Lone Nørgaard; Liza Wiedenbein; Peter Oturai; Ulla Breitenstein; Lis Adamsen

doi:10.1136/bmjsem-2015-000021

The challenge of preserving cardiorespiratory fitness in physically inactive patients with colon or breast cancer during adjuvant chemotherapy: A randomised feasibility study

Tom Møller^*, Christian Lillelund, Christina Andersen, Kira Bloomquist, Karl Bang Christensen, Bent Ejlertsen, Lone Nørgaard, Liza Wiedenbein, Peter Oturai, Ulla Breitenstein, Lis Adamsen

^*Corresponding author for this work

14 Citations (Scopus)

Abstract

Introduction Anti-neoplastic treatment is synonymous with an inactive daily life for a substantial number of patients. It remains unclear what is the optimal setting, dosage and combination of exercise and health promoting components that best facilitate patient adherence and symptom management in order to support cardio-respiratory fitness and lifestyle changes in an at-risk population of pre-illness physically inactive cancer patients. Methods Patients with breast or colon cancer referred to adjuvant chemotherapy and by the oncologists pre-screening verified as physically inactive were eligible to enter a randomised three-armed feasibility study comparing a 12-week supervised hospital-based moderate to high intensity exercise intervention or alternate an instructive home-based12-week pedometer intervention, with usual care. Results Using a recommendation based physical activity screening instrument in order to correspond with cardio-respiratory fitness (VO2 peak) proved to be an applicable method to identify pre-illness physically inactive breast and colon cancer patients. The study demonstrated convincing recruitment (67%), safety and intervention adherence among breast cancer patients; while the attendance rate for colon cancer patients was notably lower (33%). VO2-peak declined on average 12% across study groups from baseline to 12 weeks though indices towards sustaining watt performance and reduce fat mass favoured the hospital-based intervention. Pedometer use was well adapted in both breast and colon cancer patients. Conclusions Despite a fair adherence and safety, the current study calls into question whether aerobic exercise, regardless of intensity, is able to increase VO2-peak during texane-based chemotherapy in combination with Neulasta in physically inactive breast cancer patients. Trial Registration: ISRCTN24901641

Original language	English
Article number	e000021
Journal	BMJ Open Sport and Exercise Medicine
Volume	1
Number of pages	14
ISSN	2055-7647
DOIs	https://doi.org/10.1136/bmjsem-2015-000021
Publication status	Published - 2015

Keywords

Cancer
Feasibility
Rehabilitation
Research
Sports & exercise medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Møller, T., Lillelund, C., Andersen, C., Bloomquist, K., Christensen, K. B., Ejlertsen, B., Nørgaard, L., Wiedenbein, L., Oturai, P., Breitenstein, U., & Adamsen, L. (2015). The challenge of preserving cardiorespiratory fitness in physically inactive patients with colon or breast cancer during adjuvant chemotherapy: A randomised feasibility study. BMJ Open Sport and Exercise Medicine, 1, [e000021]. https://doi.org/10.1136/bmjsem-2015-000021

The challenge of preserving cardiorespiratory fitness in physically inactive patients with colon or breast cancer during adjuvant chemotherapy : A randomised feasibility study. / Møller, Tom; Lillelund, Christian; Andersen, Christina et al.

In: BMJ Open Sport and Exercise Medicine, Vol. 1, e000021, 2015.

Research output: Contribution to journal › Journal article › Research › peer-review

Møller, T, Lillelund, C, Andersen, C, Bloomquist, K, Christensen, KB , Ejlertsen, B, Nørgaard, L, Wiedenbein, L, Oturai, P, Breitenstein, U & Adamsen, L 2015, 'The challenge of preserving cardiorespiratory fitness in physically inactive patients with colon or breast cancer during adjuvant chemotherapy: A randomised feasibility study', BMJ Open Sport and Exercise Medicine, vol. 1, e000021. https://doi.org/10.1136/bmjsem-2015-000021

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abstract = "Introduction Anti-neoplastic treatment is synonymous with an inactive daily life for a substantial number of patients. It remains unclear what is the optimal setting, dosage and combination of exercise and health promoting components that best facilitate patient adherence and symptom management in order to support cardio-respiratory fitness and lifestyle changes in an at-risk population of pre-illness physically inactive cancer patients. Methods Patients with breast or colon cancer referred to adjuvant chemotherapy and by the oncologists pre-screening verified as physically inactive were eligible to enter a randomised three-armed feasibility study comparing a 12-week supervised hospital-based moderate to high intensity exercise intervention or alternate an instructive home-based12-week pedometer intervention, with usual care. Results Using a recommendation based physical activity screening instrument in order to correspond with cardio-respiratory fitness (VO2 peak) proved to be an applicable method to identify pre-illness physically inactive breast and colon cancer patients. The study demonstrated convincing recruitment (67%), safety and intervention adherence among breast cancer patients; while the attendance rate for colon cancer patients was notably lower (33%). VO2-peak declined on average 12% across study groups from baseline to 12 weeks though indices towards sustaining watt performance and reduce fat mass favoured the hospital-based intervention. Pedometer use was well adapted in both breast and colon cancer patients. Conclusions Despite a fair adherence and safety, the current study calls into question whether aerobic exercise, regardless of intensity, is able to increase VO2-peak during texane-based chemotherapy in combination with Neulasta in physically inactive breast cancer patients. Trial Registration: ISRCTN24901641",

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T2 - A randomised feasibility study

AU - Møller, Tom

AU - Lillelund, Christian

AU - Andersen, Christina

AU - Bloomquist, Kira

AU - Christensen, Karl Bang

AU - Ejlertsen, Bent

AU - Nørgaard, Lone

AU - Wiedenbein, Liza

AU - Oturai, Peter

AU - Breitenstein, Ulla

AU - Adamsen, Lis

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N2 - Introduction Anti-neoplastic treatment is synonymous with an inactive daily life for a substantial number of patients. It remains unclear what is the optimal setting, dosage and combination of exercise and health promoting components that best facilitate patient adherence and symptom management in order to support cardio-respiratory fitness and lifestyle changes in an at-risk population of pre-illness physically inactive cancer patients. Methods Patients with breast or colon cancer referred to adjuvant chemotherapy and by the oncologists pre-screening verified as physically inactive were eligible to enter a randomised three-armed feasibility study comparing a 12-week supervised hospital-based moderate to high intensity exercise intervention or alternate an instructive home-based12-week pedometer intervention, with usual care. Results Using a recommendation based physical activity screening instrument in order to correspond with cardio-respiratory fitness (VO2 peak) proved to be an applicable method to identify pre-illness physically inactive breast and colon cancer patients. The study demonstrated convincing recruitment (67%), safety and intervention adherence among breast cancer patients; while the attendance rate for colon cancer patients was notably lower (33%). VO2-peak declined on average 12% across study groups from baseline to 12 weeks though indices towards sustaining watt performance and reduce fat mass favoured the hospital-based intervention. Pedometer use was well adapted in both breast and colon cancer patients. Conclusions Despite a fair adherence and safety, the current study calls into question whether aerobic exercise, regardless of intensity, is able to increase VO2-peak during texane-based chemotherapy in combination with Neulasta in physically inactive breast cancer patients. Trial Registration: ISRCTN24901641

AB - Introduction Anti-neoplastic treatment is synonymous with an inactive daily life for a substantial number of patients. It remains unclear what is the optimal setting, dosage and combination of exercise and health promoting components that best facilitate patient adherence and symptom management in order to support cardio-respiratory fitness and lifestyle changes in an at-risk population of pre-illness physically inactive cancer patients. Methods Patients with breast or colon cancer referred to adjuvant chemotherapy and by the oncologists pre-screening verified as physically inactive were eligible to enter a randomised three-armed feasibility study comparing a 12-week supervised hospital-based moderate to high intensity exercise intervention or alternate an instructive home-based12-week pedometer intervention, with usual care. Results Using a recommendation based physical activity screening instrument in order to correspond with cardio-respiratory fitness (VO2 peak) proved to be an applicable method to identify pre-illness physically inactive breast and colon cancer patients. The study demonstrated convincing recruitment (67%), safety and intervention adherence among breast cancer patients; while the attendance rate for colon cancer patients was notably lower (33%). VO2-peak declined on average 12% across study groups from baseline to 12 weeks though indices towards sustaining watt performance and reduce fat mass favoured the hospital-based intervention. Pedometer use was well adapted in both breast and colon cancer patients. Conclusions Despite a fair adherence and safety, the current study calls into question whether aerobic exercise, regardless of intensity, is able to increase VO2-peak during texane-based chemotherapy in combination with Neulasta in physically inactive breast cancer patients. Trial Registration: ISRCTN24901641

KW - Cancer

KW - Feasibility

KW - Rehabilitation

KW - Research

KW - Sports & exercise medicine

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DO - 10.1136/bmjsem-2015-000021

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JO - BMJ Open Sport & Exercise Medicine

JF - BMJ Open Sport & Exercise Medicine

M1 - e000021

ER -

The challenge of preserving cardiorespiratory fitness in physically inactive patients with colon or breast cancer during adjuvant chemotherapy: A randomised feasibility study

Abstract

Keywords

UN SDGs

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