The Carcinogenic Agent Azoxymethane (AOM) Enhances Early Inflammation-induced Colon Crypt Pathology

Freja Albjerg Venning; Mogens Helweg Claesson; Hannelouise Kissow

doi:10.4172/1948-5956.1000229

The Carcinogenic Agent Azoxymethane (AOM) Enhances Early Inflammation-induced Colon Crypt Pathology

Freja Albjerg Venning, Mogens Helweg Claesson, Hannelouise Kissow

Endocrinology and Metabolism

4 Citations (Scopus)

Abstract

Severe combined immunodeficiency (SCID) mice transplanted with CD4+ T cells depleted of CD25+ regulatory T cells develop colitis within 2-3 weeks after the T cell transfer. In the present study we studied the effect of the carcinogen azoxymethane (AOM) on the colon crypt pathology of normal SCID mice and SCID mice with transfer colitis. AOM itself did not result in neither weight loss nor inflammation although treatment affected crypt widths and numbers. Although AOM together with T cell transfer did not increase the level of gut inflammation including COX-2 expression, AOM increased crypt changes associated with colon inflammation such as a decline in crypt numbers and an increase in crypts width throughout the large intestine. Thus it appears that AOM lower the threshold level for inflammation-induced changes which potentially may lead to neoplasia.

Original language	English
Journal	Journal of Cancer Science & Therapy
Volume	5
Issue number	11
Pages (from-to)	377-383
Number of pages	7
ISSN	1948-5956
DOIs	https://doi.org/10.4172/1948-5956.1000229
Publication status	Published - 2013

Keywords

Faculty of Health and Medical Sciences

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10.4172/1948-5956.1000229

http://dx.doi.org/10.4172/1948-5956.1000229

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title = "The Carcinogenic Agent Azoxymethane (AOM) Enhances Early Inflammation-induced Colon Crypt Pathology",

abstract = "Severe combined immunodeficiency (SCID) mice transplanted with CD4+ T cells depleted of CD25+ regulatory T cells develop colitis within 2-3 weeks after the T cell transfer. In the present study we studied the effect of the carcinogen azoxymethane (AOM) on the colon crypt pathology of normal SCID mice and SCID mice with transfer colitis. AOM itself did not result in neither weight loss nor inflammation although treatment affected crypt widths and numbers. Although AOM together with T cell transfer did not increase the level of gut inflammation including COX-2 expression, AOM increased crypt changes associated with colon inflammation such as a decline in crypt numbers and an increase in crypts width throughout the large intestine. Thus it appears that AOM lower the threshold level for inflammation-induced changes which potentially may lead to neoplasia.",

keywords = "Faculty of Health and Medical Sciences, Neoplasia, Carcinogenic agent azoxymethane, Histopathology",

author = "Venning, {Freja Albjerg} and Claesson, {Mogens Helweg} and Hannelouise Kissow",

year = "2013",

doi = "10.4172/1948-5956.1000229",

language = "English",

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T1 - The Carcinogenic Agent Azoxymethane (AOM) Enhances Early Inflammation-induced Colon Crypt Pathology

AU - Venning, Freja Albjerg

AU - Claesson, Mogens Helweg

AU - Kissow, Hannelouise

PY - 2013

Y1 - 2013

N2 - Severe combined immunodeficiency (SCID) mice transplanted with CD4+ T cells depleted of CD25+ regulatory T cells develop colitis within 2-3 weeks after the T cell transfer. In the present study we studied the effect of the carcinogen azoxymethane (AOM) on the colon crypt pathology of normal SCID mice and SCID mice with transfer colitis. AOM itself did not result in neither weight loss nor inflammation although treatment affected crypt widths and numbers. Although AOM together with T cell transfer did not increase the level of gut inflammation including COX-2 expression, AOM increased crypt changes associated with colon inflammation such as a decline in crypt numbers and an increase in crypts width throughout the large intestine. Thus it appears that AOM lower the threshold level for inflammation-induced changes which potentially may lead to neoplasia.

AB - Severe combined immunodeficiency (SCID) mice transplanted with CD4+ T cells depleted of CD25+ regulatory T cells develop colitis within 2-3 weeks after the T cell transfer. In the present study we studied the effect of the carcinogen azoxymethane (AOM) on the colon crypt pathology of normal SCID mice and SCID mice with transfer colitis. AOM itself did not result in neither weight loss nor inflammation although treatment affected crypt widths and numbers. Although AOM together with T cell transfer did not increase the level of gut inflammation including COX-2 expression, AOM increased crypt changes associated with colon inflammation such as a decline in crypt numbers and an increase in crypts width throughout the large intestine. Thus it appears that AOM lower the threshold level for inflammation-induced changes which potentially may lead to neoplasia.

KW - Faculty of Health and Medical Sciences

KW - Neoplasia

KW - Carcinogenic agent azoxymethane

KW - Histopathology

U2 - 10.4172/1948-5956.1000229

DO - 10.4172/1948-5956.1000229

M3 - Journal article

SN - 1948-5956

VL - 5

SP - 377

EP - 383

JO - Journal of Cancer Science & Therapy

JF - Journal of Cancer Science & Therapy

IS - 11

ER -

The Carcinogenic Agent Azoxymethane (AOM) Enhances Early Inflammation-induced Colon Crypt Pathology

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