The BIGTT test: a novel test for simultaneous measurement of pancreatic beta-cell function, insulin sensitivity, and glucose tolerance

TY - JOUR

T1 - The BIGTT test

T2 - a novel test for simultaneous measurement of pancreatic beta-cell function, insulin sensitivity, and glucose tolerance

AU - Hansen, Torben

AU - Drivsholm, Thomas

AU - Urhammer, Søren A

AU - Palacios, Rene T

AU - Vølund, Aage

AU - Borch-Johnsen, Knut

AU - Pedersen, Oluf

PY - 2007

Y1 - 2007

N2 - Insulin resistance and impaired beta-cell function are key elements in the pathogenesis of type 2 diabetes. We aimed to develop valid algorithms for estimation of the insulin sensitivity index (S(I)) and acute insulin response (AIR) derived from simple and cheap physiological measurements that could be used in large-scale metabolic, genetic, and epidemiological studies.

AB - Insulin resistance and impaired beta-cell function are key elements in the pathogenesis of type 2 diabetes. We aimed to develop valid algorithms for estimation of the insulin sensitivity index (S(I)) and acute insulin response (AIR) derived from simple and cheap physiological measurements that could be used in large-scale metabolic, genetic, and epidemiological studies.

KW - Aged

KW - Blood Glucose

KW - Glucose Intolerance

KW - Glucose Tolerance Test

KW - Homeostasis

KW - Humans

KW - Hypoglycemic Agents

KW - Insulin

KW - Insulin-Secreting Cells

KW - Middle Aged

KW - Reproducibility of Results

KW - Tolbutamide

U2 - 10.2337/dc06-1240

DO - 10.2337/dc06-1240

M3 - Journal article

C2 - 17259491

SN - 0149-5992

VL - 30

SP - 257

EP - 262

JO - Diabetes Care

JF - Diabetes Care

IS - 2

ER -