The associative brain at work: Evidence from paired associative stimulation studies in humans

TY - JOUR

T1 - The associative brain at work

T2 - Evidence from paired associative stimulation studies in humans

AU - Suppa, A.

AU - Quartarone, A.

AU - Siebner, H.

AU - Chen, R.

AU - Di Lazzaro, V.

AU - Del Giudice, P.

AU - Paulus, Walter

AU - Rothwell, J. C.

AU - Ziemann, U.

AU - Classen, J.

PY - 2017

Y1 - 2017

N2 - The original protocol of Paired Associative Stimulation (PAS) in humans implies repetitive cortical and peripheral nerve stimuli, delivered at specific inter-stimulus intervals, able to elicit non-invasively long-term potentiation (LTP)- and long-term depression (LTD)-like plasticity in the human motor cortex. PAS has been designed to drive cortical LTP/LTD according to the Hebbian rule of associative plasticity. Over the last two decades, a growing number of researchers have increasingly used the PAS technique to assess cortical associative plasticity in healthy humans and in patients with movement disorders and other neuropsychiatric diseases. The present review covers the physiology, pharmacology, pathology and motor effects of PAS. Further sections of the review focus on new protocols of “modified PAS” and possible future application of PAS in neuromorphic circuits designed for brain-computer interface.

AB - The original protocol of Paired Associative Stimulation (PAS) in humans implies repetitive cortical and peripheral nerve stimuli, delivered at specific inter-stimulus intervals, able to elicit non-invasively long-term potentiation (LTP)- and long-term depression (LTD)-like plasticity in the human motor cortex. PAS has been designed to drive cortical LTP/LTD according to the Hebbian rule of associative plasticity. Over the last two decades, a growing number of researchers have increasingly used the PAS technique to assess cortical associative plasticity in healthy humans and in patients with movement disorders and other neuropsychiatric diseases. The present review covers the physiology, pharmacology, pathology and motor effects of PAS. Further sections of the review focus on new protocols of “modified PAS” and possible future application of PAS in neuromorphic circuits designed for brain-computer interface.

KW - Paired associative stimulation

KW - Plasticity

KW - Primary motor cortex

KW - STDP

U2 - 10.1016/j.clinph.2017.08.003

DO - 10.1016/j.clinph.2017.08.003

M3 - Review

C2 - 28938144

AN - SCOPUS:85029515782

SN - 1388-2457

VL - 128

SP - 2140

EP - 2164

JO - Clinical Neurophysiology

JF - Clinical Neurophysiology

IS - 11

ER -