The association of fatigue, comorbidity burden, disease activity, disability and gross domestic product in patients with rheumatoid arthritis. Results from 34 countries participating in the Quest-RA program

Kathrine Lederballe Grøn; Lykke Midtbøll Ornbjerg; Merete Lund Hetland; Fawad Aslam; Nasim A Khan; Johannes W G Jacobs; Dan Henrohn; J J Rasker; Markku J Kauppi; Hui-Chu Lang; Licia M H Mota; Amita Aggarwal; Hisahi Yamanaka; Humeira Badsha; Laure Gossec; Maurizio Cutolo; Gianfranco Ferraccioli; Elisa Gremese; Eun Bong Lee; Nevsun Inanc; Haner Direskeneli; Peter Taylor; Margriet Huisman; Rieke Alten; Christoph Pohl; Omondi Oyoo; Sigita Stropuviene; Alexandrosos A Drosos; Eduardo Kerzberg; Codorina Ancuta; Ayman Mofti; Martin Bergman; Jaqueline Detert; Zaraa I Selim; Essam A Abda; Blerta Rexhepi; Tuulikki Sokka

The association of fatigue, comorbidity burden, disease activity, disability and gross domestic product in patients with rheumatoid arthritis. Results from 34 countries participating in the Quest-RA program

Kathrine Lederballe Grøn, Lykke Midtbøll Ornbjerg, Merete Lund Hetland, Fawad Aslam, Nasim A Khan, Johannes W G Jacobs, Dan Henrohn, J J Rasker, Markku J Kauppi, Hui-Chu Lang, Licia M H Mota, Amita Aggarwal, Hisahi Yamanaka, Humeira Badsha, Laure Gossec, Maurizio Cutolo, Gianfranco Ferraccioli, Elisa Gremese, Eun Bong Lee, Nevsun InancHaner Direskeneli, Peter Taylor, Margriet Huisman, Rieke Alten, Christoph Pohl, Omondi Oyoo, Sigita Stropuviene, Alexandrosos A Drosos, Eduardo Kerzberg, Codorina Ancuta, Ayman Mofti, Martin Bergman, Jaqueline Detert, Zaraa I Selim, Essam A Abda, Blerta Rexhepi, Tuulikki Sokka

Department of Clinical Medicine

41 Citations (Scopus)

Abstract

Objective The aim is to assess the prevalence of comorbidities and to further analyse to which degree fatigue can be explained by comorbidity burden, disease activity, disability and gross domestic product (GDP) in patients with rheumatoid arthritis (RA). Methods Nine thousands eight hundred seventy-four patients from 34 countries, 16 with high GDP (>24.000 US dollars [USD] per capita) and 18 low-GDP countries (<24.000 USD) participated in the Quantitative Standard monitoring of Patients with RA (QUEST-RA) study. The prevalence of 31 comorbid conditions, fatigue (0-10 cm visual analogue scale [VAS] [10=worst]), disease activity in 28 joints (DAS28), and physical disability (Health Assessment Questionnaire score [HAQ]) were assessed. Univariate and multivariate linear regression analyses were performed to assess the association between fatigue and comorbidities, disease activity, disability and GDP. Results Overall, patients reported a median of 2 comorbid conditions of which hypertension (31.5%), osteoporosis (17.6%), osteoarthritis (15.5%) and hyperlipidaemia (14.2%) were the most prevalent. The majority of comorbidities were more common in high-GDP countries. The median fatigue score was 4.4 (4.8 in low-GDP countries and 3.8 in high-GDP countries, p<0.001). In low-GDP countries 25.4% of the patients had a high level of fatigue (>6.6) compared with 23.0% in high-GDP countries (p<0.001). In univariate analysis, fatigue increased with increasing number of comorbidities, disease activity and disability in both high- and low-GDP countries. In multivariate analysis of all countries, these 3 variables explained 29.4% of the variability, whereas GDP was not significant. Conclusion Fatigue is a widespread problem associated with high comorbidity burden, disease activity and disability regardless of GDP.

Original language	English
Journal	Clinical and Experimental Rheumatology
Volume	32
Issue number	6
Pages (from-to)	869-877
Number of pages	9
ISSN	0392-856X
Publication status	Published - 21 Oct 2014

Keywords

Arthritis, Rheumatoid
Chi-Square Distribution
Comorbidity
Cost of Illness
Disability Evaluation
Fatigue
Female
Gross Domestic Product
Humans
Linear Models
Male
Middle Aged
Multivariate Analysis
Predictive Value of Tests
Prevalence
Questionnaires
Risk Factors
Severity of Illness Index
Socioeconomic Factors

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Grøn, K. L., Ornbjerg, L. M., Hetland, M. L., Aslam, F., Khan, N. A., Jacobs, J. W. G., Henrohn, D., Rasker, J. J., Kauppi, M. J., Lang, H-C., Mota, L. M. H., Aggarwal, A., Yamanaka, H., Badsha, H., Gossec, L., Cutolo, M., Ferraccioli, G., Gremese, E., Bong Lee, E., ... Sokka, T. (2014). The association of fatigue, comorbidity burden, disease activity, disability and gross domestic product in patients with rheumatoid arthritis. Results from 34 countries participating in the Quest-RA program. Clinical and Experimental Rheumatology, 32(6), 869-877.

The association of fatigue, comorbidity burden, disease activity, disability and gross domestic product in patients with rheumatoid arthritis. Results from 34 countries participating in the Quest-RA program. / Grøn, Kathrine Lederballe; Ornbjerg, Lykke Midtbøll; Hetland, Merete Lund et al.

In: Clinical and Experimental Rheumatology, Vol. 32, No. 6, 21.10.2014, p. 869-877.

Research output: Contribution to journal › Journal article › Research › peer-review

Grøn, KL, Ornbjerg, LM, Hetland, ML, Aslam, F, Khan, NA, Jacobs, JWG, Henrohn, D, Rasker, JJ, Kauppi, MJ, Lang, H-C, Mota, LMH, Aggarwal, A, Yamanaka, H, Badsha, H, Gossec, L, Cutolo, M, Ferraccioli, G, Gremese, E, Bong Lee, E, Inanc, N, Direskeneli, H, Taylor, P, Huisman, M, Alten, R, Pohl, C, Oyoo, O, Stropuviene, S, Drosos, AA, Kerzberg, E, Ancuta, C, Mofti, A, Bergman, M, Detert, J, Selim, ZI, Abda, EA, Rexhepi, B & Sokka, T 2014, 'The association of fatigue, comorbidity burden, disease activity, disability and gross domestic product in patients with rheumatoid arthritis. Results from 34 countries participating in the Quest-RA program', Clinical and Experimental Rheumatology, vol. 32, no. 6, pp. 869-877.

Grøn, Kathrine Lederballe ; Ornbjerg, Lykke Midtbøll ; Hetland, Merete Lund et al. / The association of fatigue, comorbidity burden, disease activity, disability and gross domestic product in patients with rheumatoid arthritis. Results from 34 countries participating in the Quest-RA program. In: Clinical and Experimental Rheumatology. 2014 ; Vol. 32, No. 6. pp. 869-877.

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title = "The association of fatigue, comorbidity burden, disease activity, disability and gross domestic product in patients with rheumatoid arthritis. Results from 34 countries participating in the Quest-RA program",

abstract = "Objective The aim is to assess the prevalence of comorbidities and to further analyse to which degree fatigue can be explained by comorbidity burden, disease activity, disability and gross domestic product (GDP) in patients with rheumatoid arthritis (RA). Methods Nine thousands eight hundred seventy-four patients from 34 countries, 16 with high GDP (>24.000 US dollars [USD] per capita) and 18 low-GDP countries (<24.000 USD) participated in the Quantitative Standard monitoring of Patients with RA (QUEST-RA) study. The prevalence of 31 comorbid conditions, fatigue (0-10 cm visual analogue scale [VAS] [10=worst]), disease activity in 28 joints (DAS28), and physical disability (Health Assessment Questionnaire score [HAQ]) were assessed. Univariate and multivariate linear regression analyses were performed to assess the association between fatigue and comorbidities, disease activity, disability and GDP. Results Overall, patients reported a median of 2 comorbid conditions of which hypertension (31.5%), osteoporosis (17.6%), osteoarthritis (15.5%) and hyperlipidaemia (14.2%) were the most prevalent. The majority of comorbidities were more common in high-GDP countries. The median fatigue score was 4.4 (4.8 in low-GDP countries and 3.8 in high-GDP countries, p<0.001). In low-GDP countries 25.4% of the patients had a high level of fatigue (>6.6) compared with 23.0% in high-GDP countries (p<0.001). In univariate analysis, fatigue increased with increasing number of comorbidities, disease activity and disability in both high- and low-GDP countries. In multivariate analysis of all countries, these 3 variables explained 29.4% of the variability, whereas GDP was not significant. Conclusion Fatigue is a widespread problem associated with high comorbidity burden, disease activity and disability regardless of GDP.",

keywords = "Arthritis, Rheumatoid, Chi-Square Distribution, Comorbidity, Cost of Illness, Disability Evaluation, Fatigue, Female, Gross Domestic Product, Humans, Linear Models, Male, Middle Aged, Multivariate Analysis, Predictive Value of Tests, Prevalence, Questionnaires, Risk Factors, Severity of Illness Index, Socioeconomic Factors",

author = "Gr{\o}n, {Kathrine Lederballe} and Ornbjerg, {Lykke Midtb{\o}ll} and Hetland, {Merete Lund} and Fawad Aslam and Khan, {Nasim A} and Jacobs, {Johannes W G} and Dan Henrohn and Rasker, {J J} and Kauppi, {Markku J} and Hui-Chu Lang and Mota, {Licia M H} and Amita Aggarwal and Hisahi Yamanaka and Humeira Badsha and Laure Gossec and Maurizio Cutolo and Gianfranco Ferraccioli and Elisa Gremese and {Bong Lee}, Eun and Nevsun Inanc and Haner Direskeneli and Peter Taylor and Margriet Huisman and Rieke Alten and Christoph Pohl and Omondi Oyoo and Sigita Stropuviene and Drosos, {Alexandrosos A} and Eduardo Kerzberg and Codorina Ancuta and Ayman Mofti and Martin Bergman and Jaqueline Detert and Selim, {Zaraa I} and Abda, {Essam A} and Blerta Rexhepi and Tuulikki Sokka",

year = "2014",

month = oct,

day = "21",

language = "English",

volume = "32",

pages = "869--877",

journal = "Clinical and Experimental Rheumatology",

issn = "0392-856X",

publisher = "Pacini Editore SpA",

number = "6",

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TY - JOUR

T1 - The association of fatigue, comorbidity burden, disease activity, disability and gross domestic product in patients with rheumatoid arthritis. Results from 34 countries participating in the Quest-RA program

AU - Grøn, Kathrine Lederballe

AU - Ornbjerg, Lykke Midtbøll

AU - Hetland, Merete Lund

AU - Aslam, Fawad

AU - Khan, Nasim A

AU - Jacobs, Johannes W G

AU - Henrohn, Dan

AU - Rasker, J J

AU - Kauppi, Markku J

AU - Lang, Hui-Chu

AU - Mota, Licia M H

AU - Aggarwal, Amita

AU - Yamanaka, Hisahi

AU - Badsha, Humeira

AU - Gossec, Laure

AU - Cutolo, Maurizio

AU - Ferraccioli, Gianfranco

AU - Gremese, Elisa

AU - Bong Lee, Eun

AU - Inanc, Nevsun

AU - Direskeneli, Haner

AU - Taylor, Peter

AU - Huisman, Margriet

AU - Alten, Rieke

AU - Pohl, Christoph

AU - Oyoo, Omondi

AU - Stropuviene, Sigita

AU - Drosos, Alexandrosos A

AU - Kerzberg, Eduardo

AU - Ancuta, Codorina

AU - Mofti, Ayman

AU - Bergman, Martin

AU - Detert, Jaqueline

AU - Selim, Zaraa I

AU - Abda, Essam A

AU - Rexhepi, Blerta

AU - Sokka, Tuulikki

PY - 2014/10/21

Y1 - 2014/10/21

N2 - Objective The aim is to assess the prevalence of comorbidities and to further analyse to which degree fatigue can be explained by comorbidity burden, disease activity, disability and gross domestic product (GDP) in patients with rheumatoid arthritis (RA). Methods Nine thousands eight hundred seventy-four patients from 34 countries, 16 with high GDP (>24.000 US dollars [USD] per capita) and 18 low-GDP countries (<24.000 USD) participated in the Quantitative Standard monitoring of Patients with RA (QUEST-RA) study. The prevalence of 31 comorbid conditions, fatigue (0-10 cm visual analogue scale [VAS] [10=worst]), disease activity in 28 joints (DAS28), and physical disability (Health Assessment Questionnaire score [HAQ]) were assessed. Univariate and multivariate linear regression analyses were performed to assess the association between fatigue and comorbidities, disease activity, disability and GDP. Results Overall, patients reported a median of 2 comorbid conditions of which hypertension (31.5%), osteoporosis (17.6%), osteoarthritis (15.5%) and hyperlipidaemia (14.2%) were the most prevalent. The majority of comorbidities were more common in high-GDP countries. The median fatigue score was 4.4 (4.8 in low-GDP countries and 3.8 in high-GDP countries, p<0.001). In low-GDP countries 25.4% of the patients had a high level of fatigue (>6.6) compared with 23.0% in high-GDP countries (p<0.001). In univariate analysis, fatigue increased with increasing number of comorbidities, disease activity and disability in both high- and low-GDP countries. In multivariate analysis of all countries, these 3 variables explained 29.4% of the variability, whereas GDP was not significant. Conclusion Fatigue is a widespread problem associated with high comorbidity burden, disease activity and disability regardless of GDP.

AB - Objective The aim is to assess the prevalence of comorbidities and to further analyse to which degree fatigue can be explained by comorbidity burden, disease activity, disability and gross domestic product (GDP) in patients with rheumatoid arthritis (RA). Methods Nine thousands eight hundred seventy-four patients from 34 countries, 16 with high GDP (>24.000 US dollars [USD] per capita) and 18 low-GDP countries (<24.000 USD) participated in the Quantitative Standard monitoring of Patients with RA (QUEST-RA) study. The prevalence of 31 comorbid conditions, fatigue (0-10 cm visual analogue scale [VAS] [10=worst]), disease activity in 28 joints (DAS28), and physical disability (Health Assessment Questionnaire score [HAQ]) were assessed. Univariate and multivariate linear regression analyses were performed to assess the association between fatigue and comorbidities, disease activity, disability and GDP. Results Overall, patients reported a median of 2 comorbid conditions of which hypertension (31.5%), osteoporosis (17.6%), osteoarthritis (15.5%) and hyperlipidaemia (14.2%) were the most prevalent. The majority of comorbidities were more common in high-GDP countries. The median fatigue score was 4.4 (4.8 in low-GDP countries and 3.8 in high-GDP countries, p<0.001). In low-GDP countries 25.4% of the patients had a high level of fatigue (>6.6) compared with 23.0% in high-GDP countries (p<0.001). In univariate analysis, fatigue increased with increasing number of comorbidities, disease activity and disability in both high- and low-GDP countries. In multivariate analysis of all countries, these 3 variables explained 29.4% of the variability, whereas GDP was not significant. Conclusion Fatigue is a widespread problem associated with high comorbidity burden, disease activity and disability regardless of GDP.

KW - Arthritis, Rheumatoid

KW - Chi-Square Distribution

KW - Comorbidity

KW - Cost of Illness

KW - Disability Evaluation

KW - Fatigue

KW - Female

KW - Gross Domestic Product

KW - Humans

KW - Linear Models

KW - Male

KW - Middle Aged

KW - Multivariate Analysis

KW - Predictive Value of Tests

KW - Prevalence

KW - Questionnaires

KW - Risk Factors

KW - Severity of Illness Index

KW - Socioeconomic Factors

M3 - Journal article

C2 - 25327997

SN - 0392-856X

VL - 32

SP - 869

EP - 877

JO - Clinical and Experimental Rheumatology

JF - Clinical and Experimental Rheumatology

IS - 6

ER -