The association between norepinephrine and metabolism in patients with major depression

Jesper Futtrup; Merete Nordentoft; Betina Elfving; Jesper Krogh

doi:10.1016/j.npbr.2018.07.002

The association between norepinephrine and metabolism in patients with major depression

Jesper Futtrup^*, Merete Nordentoft, Betina Elfving, Jesper Krogh

^*Corresponding author for this work

Department of Clinical Medicine

3 Citations (Scopus)

Abstract

Background: Previous studies indicate that levels of plasma norepinephrine (p-NE) are altered in depressed patients. However, it is unclear whether altered NE metabolism is involved in the pathogenic association between depression and cardiovascular disease. The aim of the present study was, firstly, to investigate if p-NE levels differ between patients with major depression and healthy controls. Secondly, the study sought to assess the associations between p-NE and metabolic variables in all participants. The third and final aim of the study was to assess if the associations between p-NE and metabolic variables are influenced by disease status (depression vs. healthy). Methods: 108 patients with major depression and 44 healthy controls were tested for levels of p-NE and metabolic variables that affect cardiovascular risk. Results: The median level of p-NE in depressed patients (DSM-IV) was 2636 pg/ml, (IQR 2094–3143) and 2279 pg/ml (IQR 2007–2562) in non-depressed controls (p = 0.013). However, the difference between p-NE levels was non-significant when adjusted for daily smoking (p = 0.138). Significant associations (p ≤ 0.05) were observed between p-NE and p-lipids, mean arterial blood pressure, p-insulin, quantitative insulin sensitivity check index as well as inflammatory markers. Conclusions: Elevated levels of p-NE observed in patients with major depression were attributable to daily smoking, rather than to the depressive disorder. Important associations were found between p-NE and metabolic variables that affect cardiovascular risk. This is interesting from a clinical point of view, since affected individuals may benefit from simple and inexpensive treatments that influence sympathetic activity. All associations were independent of disease status.

Original language	English
Journal	Neurology Psychiatry and Brain Research
Volume	30
Pages (from-to)	91-97
Number of pages	7
ISSN	0941-9500
DOIs	https://doi.org/10.1016/j.npbr.2018.07.002
Publication status	Published - 1 Dec 2018

Keywords

Cardiovascular risk
Depression
Metabolism
Norepinephrine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.npbr.2018.07.002

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@article{56d78c16621541d59fbb50bc37e61dea,

title = "The association between norepinephrine and metabolism in patients with major depression",

abstract = "Background: Previous studies indicate that levels of plasma norepinephrine (p-NE) are altered in depressed patients. However, it is unclear whether altered NE metabolism is involved in the pathogenic association between depression and cardiovascular disease. The aim of the present study was, firstly, to investigate if p-NE levels differ between patients with major depression and healthy controls. Secondly, the study sought to assess the associations between p-NE and metabolic variables in all participants. The third and final aim of the study was to assess if the associations between p-NE and metabolic variables are influenced by disease status (depression vs. healthy). Methods: 108 patients with major depression and 44 healthy controls were tested for levels of p-NE and metabolic variables that affect cardiovascular risk. Results: The median level of p-NE in depressed patients (DSM-IV) was 2636 pg/ml, (IQR 2094–3143) and 2279 pg/ml (IQR 2007–2562) in non-depressed controls (p = 0.013). However, the difference between p-NE levels was non-significant when adjusted for daily smoking (p = 0.138). Significant associations (p ≤ 0.05) were observed between p-NE and p-lipids, mean arterial blood pressure, p-insulin, quantitative insulin sensitivity check index as well as inflammatory markers. Conclusions: Elevated levels of p-NE observed in patients with major depression were attributable to daily smoking, rather than to the depressive disorder. Important associations were found between p-NE and metabolic variables that affect cardiovascular risk. This is interesting from a clinical point of view, since affected individuals may benefit from simple and inexpensive treatments that influence sympathetic activity. All associations were independent of disease status.",

keywords = "Cardiovascular risk, Depression, Metabolism, Norepinephrine",

author = "Jesper Futtrup and Merete Nordentoft and Betina Elfving and Jesper Krogh",

year = "2018",

month = dec,

day = "1",

doi = "10.1016/j.npbr.2018.07.002",

language = "English",

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pages = "91--97",

journal = "Neurology, Psychiatry and Brain Research",

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T1 - The association between norepinephrine and metabolism in patients with major depression

AU - Futtrup, Jesper

AU - Nordentoft, Merete

AU - Elfving, Betina

AU - Krogh, Jesper

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Background: Previous studies indicate that levels of plasma norepinephrine (p-NE) are altered in depressed patients. However, it is unclear whether altered NE metabolism is involved in the pathogenic association between depression and cardiovascular disease. The aim of the present study was, firstly, to investigate if p-NE levels differ between patients with major depression and healthy controls. Secondly, the study sought to assess the associations between p-NE and metabolic variables in all participants. The third and final aim of the study was to assess if the associations between p-NE and metabolic variables are influenced by disease status (depression vs. healthy). Methods: 108 patients with major depression and 44 healthy controls were tested for levels of p-NE and metabolic variables that affect cardiovascular risk. Results: The median level of p-NE in depressed patients (DSM-IV) was 2636 pg/ml, (IQR 2094–3143) and 2279 pg/ml (IQR 2007–2562) in non-depressed controls (p = 0.013). However, the difference between p-NE levels was non-significant when adjusted for daily smoking (p = 0.138). Significant associations (p ≤ 0.05) were observed between p-NE and p-lipids, mean arterial blood pressure, p-insulin, quantitative insulin sensitivity check index as well as inflammatory markers. Conclusions: Elevated levels of p-NE observed in patients with major depression were attributable to daily smoking, rather than to the depressive disorder. Important associations were found between p-NE and metabolic variables that affect cardiovascular risk. This is interesting from a clinical point of view, since affected individuals may benefit from simple and inexpensive treatments that influence sympathetic activity. All associations were independent of disease status.

AB - Background: Previous studies indicate that levels of plasma norepinephrine (p-NE) are altered in depressed patients. However, it is unclear whether altered NE metabolism is involved in the pathogenic association between depression and cardiovascular disease. The aim of the present study was, firstly, to investigate if p-NE levels differ between patients with major depression and healthy controls. Secondly, the study sought to assess the associations between p-NE and metabolic variables in all participants. The third and final aim of the study was to assess if the associations between p-NE and metabolic variables are influenced by disease status (depression vs. healthy). Methods: 108 patients with major depression and 44 healthy controls were tested for levels of p-NE and metabolic variables that affect cardiovascular risk. Results: The median level of p-NE in depressed patients (DSM-IV) was 2636 pg/ml, (IQR 2094–3143) and 2279 pg/ml (IQR 2007–2562) in non-depressed controls (p = 0.013). However, the difference between p-NE levels was non-significant when adjusted for daily smoking (p = 0.138). Significant associations (p ≤ 0.05) were observed between p-NE and p-lipids, mean arterial blood pressure, p-insulin, quantitative insulin sensitivity check index as well as inflammatory markers. Conclusions: Elevated levels of p-NE observed in patients with major depression were attributable to daily smoking, rather than to the depressive disorder. Important associations were found between p-NE and metabolic variables that affect cardiovascular risk. This is interesting from a clinical point of view, since affected individuals may benefit from simple and inexpensive treatments that influence sympathetic activity. All associations were independent of disease status.

KW - Cardiovascular risk

KW - Depression

KW - Metabolism

KW - Norepinephrine

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U2 - 10.1016/j.npbr.2018.07.002

DO - 10.1016/j.npbr.2018.07.002

M3 - Journal article

AN - SCOPUS:85049922735

SN - 0941-9500

VL - 30

SP - 91

EP - 97

JO - Neurology, Psychiatry and Brain Research

JF - Neurology, Psychiatry and Brain Research

ER -

The association between norepinephrine and metabolism in patients with major depression

Abstract

Keywords

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