The apolipoprotein E epsilon4-allele and antihypertensive treatment are associated with increased risk of cerebral MRI white matter hyperintensities.

TY - JOUR

T1 - The apolipoprotein E epsilon4-allele and antihypertensive treatment are associated with increased risk of cerebral MRI white matter hyperintensities.

AU - Høgh, P

AU - Garde, Ellen

AU - Mortensen, Erik Lykke

AU - Jorgensen, O. S.

AU - Krabbe, Katrine

AU - Waldemar, G

N1 - Keywords: Aged, 80 and over; Alcohol Drinking; Antihypertensive Agents; Apolipoprotein E4; Brain; Cohort Studies; Female; Genotype; Humans; Magnetic Resonance Imaging; Male; Risk Factors

PY - 2007

Y1 - 2007

N2 - OBJECTIVE: Apolipoprotein E-epsilon4 (APOE-epsilon4) is a potential risk factor for cerebral vascular disease. The aim of the present study was to examine the relative importance of APOE-epsilon4 and other relevant risk factors for the extent of cerebral white matter hyperintensity (WMH) in a community-based sample of elderly subjects. MATERIALS AND METHODS: From a cohort of 976 subjects born in 1914, APOE genotype was determined and MRI examinations were carried out in 75 subjects. WMH were rated using a standard semi-quantitative method. ANOVA and regression analyses were conducted to explore the relative importance of the potential risk factors. RESULTS: APOE genotype and antihypertensive treatment were significantly associated with severity of total WMH load (P < 0.05). CONCLUSIONS: The study confirmed the association between APOE-epsilon4 and WMH. Pharmaceutical treatment for arterial hypertension was also associated with the total burden of WMH in this study.

AB - OBJECTIVE: Apolipoprotein E-epsilon4 (APOE-epsilon4) is a potential risk factor for cerebral vascular disease. The aim of the present study was to examine the relative importance of APOE-epsilon4 and other relevant risk factors for the extent of cerebral white matter hyperintensity (WMH) in a community-based sample of elderly subjects. MATERIALS AND METHODS: From a cohort of 976 subjects born in 1914, APOE genotype was determined and MRI examinations were carried out in 75 subjects. WMH were rated using a standard semi-quantitative method. ANOVA and regression analyses were conducted to explore the relative importance of the potential risk factors. RESULTS: APOE genotype and antihypertensive treatment were significantly associated with severity of total WMH load (P < 0.05). CONCLUSIONS: The study confirmed the association between APOE-epsilon4 and WMH. Pharmaceutical treatment for arterial hypertension was also associated with the total burden of WMH in this study.

U2 - 10.1111/j.1600-0404.2006.00779.x

DO - 10.1111/j.1600-0404.2006.00779.x

M3 - Journal article

C2 - 17376122

SN - 0001-6314

VL - 115

SP - 248

EP - 253

JO - Acta Neurologica Scandinavica

JF - Acta Neurologica Scandinavica

IS - 4

ER -