The acid-labile subunit of the ternary insulin-like growth factor complex in cirrhosis: relation to liver dysfunction

TY - JOUR

T1 - The acid-labile subunit of the ternary insulin-like growth factor complex in cirrhosis

T2 - relation to liver dysfunction

AU - Møller, S

AU - Juul, A

AU - Becker, U

AU - Henriksen, J H

PY - 2000

Y1 - 2000

N2 - In the circulation, insulin-like growth factor-I (IGF-I) is bound in a trimeric complex of 150 kDa with IGF binding protein-3 (IGFBP-3) and the acid-labile subunit (ALS). Whereas circulating IGF-I and IGFBP-3 are reported to be low in patients with chronic liver failure, the level of ALS has not been described in relation to hepatic dysfunction. The aim of the present study was therefore to measure circulating and hepatic venous concentrations of ALS in relation to hepatic function and the IGF axis.

AB - In the circulation, insulin-like growth factor-I (IGF-I) is bound in a trimeric complex of 150 kDa with IGF binding protein-3 (IGFBP-3) and the acid-labile subunit (ALS). Whereas circulating IGF-I and IGFBP-3 are reported to be low in patients with chronic liver failure, the level of ALS has not been described in relation to hepatic dysfunction. The aim of the present study was therefore to measure circulating and hepatic venous concentrations of ALS in relation to hepatic function and the IGF axis.

M3 - Journal article

SN - 0169-5185

VL - 32

SP - 441

EP - 446

JO - Journal of Hepatology, Supplement

JF - Journal of Hepatology, Supplement

IS - 3

ER -