Tetranectin positive expression in tumour tissue leads to longer survival in Danish women with ovarian cancer. Results from the 'Malova' ovarian cancer study

Mel C Heeran; Lene Rask; Claus K Høgdall; Susanne K Kjaer; Lise Christensen; Allan Jensen; Jan Blaakaer; I B Jarle Christensen; Estrid V S Høgdall

doi:10.1111/apm.12368

Tetranectin positive expression in tumour tissue leads to longer survival in Danish women with ovarian cancer. Results from the 'Malova' ovarian cancer study

Mel C Heeran, Lene Rask, Claus K Høgdall, Susanne K Kjaer, Lise Christensen, Allan Jensen, Jan Blaakaer, I B Jarle Christensen, Estrid V S Høgdall

Department of Clinical Medicine

6 Citations (Scopus)

Abstract

The primary objective of this study was to analyse Tetranectin (TN) expression in tumour tissues and TN serum concentration in 758 women with epithelial ovarian tumours. The second was to evaluate, whether TN tissue expression levels correlate with clinico-pathological parameters and prognosis of the disease. Using tissue arrays we analysed the expression levels in tissues from 166 women with borderline ovarian tumours (BOTs) and 592 women with ovarian cancer (OC). A panel of three antibodies was used for immunohistochemistry: a polyclonal and two monoclonal antibodies. Serum TN was measured using the polyclonal antibody A-371. Univariate survival analyses stratified for chemotherapy showed that positive tissue TN as demonstrated by the polyclonal antibody indicated a significantly longer overall survival (OS) (p = 0.0001) as well as cancer specific survival (CSS) (p < 0.0001). High serum TN was likewise found to imply longer OS (p < 0.0001) and CSS (p < 0.0001), whereas tissue staining with the two monoclonal antibodies failed to demonstrate any significant correlation with either survival type. Univariate Kaplan-Meier survival analysis performed on all OC cases showed a significantly longer OS (p = 0.0009) and CSS (p = 0.0006) for women with TN positive tumour tissue and in women with high serum TN levels (p < 0.0001 for both). However, in the multivariate Cox regression analysis, only serum TN was found to be an independent prognostic factor for OS (p = 0.01) and not for CSS (p = 0.08). In conclusion, our results predict that a positive TN expression of both tumour tissue and serum points to a more favourable outcome for OC patients.

Original language	English
Journal	APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
Volume	123
Issue number	5
Pages (from-to)	401-409
Number of pages	9
ISSN	0903-4641
DOIs	https://doi.org/10.1111/apm.12368
Publication status	Published - 1 May 2015

Keywords

Adult
Aged
Biomarkers, Tumor
Denmark
Female
Follow-Up Studies
Humans
Immunohistochemistry
Kaplan-Meier Estimate
Lectins, C-Type
Middle Aged
Neoplasms, Glandular and Epithelial
Ovarian Neoplasms
Prognosis
Risk Factors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/apm.12368

Cite this

Heeran, M. C., Rask, L., Høgdall, C. K., Kjaer, S. K., Christensen, L., Jensen, A., Blaakaer, J., Jarle Christensen, I. B., & Høgdall, E. V. S. (2015). Tetranectin positive expression in tumour tissue leads to longer survival in Danish women with ovarian cancer. Results from the 'Malova' ovarian cancer study. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 123(5), 401-409. https://doi.org/10.1111/apm.12368

Tetranectin positive expression in tumour tissue leads to longer survival in Danish women with ovarian cancer. Results from the 'Malova' ovarian cancer study. / Heeran, Mel C; Rask, Lene; Høgdall, Claus K et al.
In: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, Vol. 123, No. 5, 01.05.2015, p. 401-409.

Research output: Contribution to journal › Journal article › Research › peer-review

Heeran, MC, Rask, L, Høgdall, CK , Kjaer, SK, Christensen, L, Jensen, A, Blaakaer, J, Jarle Christensen, IB & Høgdall, EVS 2015, 'Tetranectin positive expression in tumour tissue leads to longer survival in Danish women with ovarian cancer. Results from the 'Malova' ovarian cancer study', APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, vol. 123, no. 5, pp. 401-409. https://doi.org/10.1111/apm.12368

@article{7310bfe4dfd244f4a0f1afb0c3d08aed,

title = "Tetranectin positive expression in tumour tissue leads to longer survival in Danish women with ovarian cancer. Results from the 'Malova' ovarian cancer study",

abstract = "The primary objective of this study was to analyse Tetranectin (TN) expression in tumour tissues and TN serum concentration in 758 women with epithelial ovarian tumours. The second was to evaluate, whether TN tissue expression levels correlate with clinico-pathological parameters and prognosis of the disease. Using tissue arrays we analysed the expression levels in tissues from 166 women with borderline ovarian tumours (BOTs) and 592 women with ovarian cancer (OC). A panel of three antibodies was used for immunohistochemistry: a polyclonal and two monoclonal antibodies. Serum TN was measured using the polyclonal antibody A-371. Univariate survival analyses stratified for chemotherapy showed that positive tissue TN as demonstrated by the polyclonal antibody indicated a significantly longer overall survival (OS) (p = 0.0001) as well as cancer specific survival (CSS) (p < 0.0001). High serum TN was likewise found to imply longer OS (p < 0.0001) and CSS (p < 0.0001), whereas tissue staining with the two monoclonal antibodies failed to demonstrate any significant correlation with either survival type. Univariate Kaplan-Meier survival analysis performed on all OC cases showed a significantly longer OS (p = 0.0009) and CSS (p = 0.0006) for women with TN positive tumour tissue and in women with high serum TN levels (p < 0.0001 for both). However, in the multivariate Cox regression analysis, only serum TN was found to be an independent prognostic factor for OS (p = 0.01) and not for CSS (p = 0.08). In conclusion, our results predict that a positive TN expression of both tumour tissue and serum points to a more favourable outcome for OC patients.",

keywords = "Adult, Aged, Biomarkers, Tumor, Denmark, Female, Follow-Up Studies, Humans, Immunohistochemistry, Kaplan-Meier Estimate, Lectins, C-Type, Middle Aged, Neoplasms, Glandular and Epithelial, Ovarian Neoplasms, Prognosis, Risk Factors",

author = "Heeran, {Mel C} and Lene Rask and H{\o}gdall, {Claus K} and Kjaer, {Susanne K} and Lise Christensen and Allan Jensen and Jan Blaakaer and {Jarle Christensen}, {I B} and H{\o}gdall, {Estrid V S}",

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doi = "10.1111/apm.12368",

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T1 - Tetranectin positive expression in tumour tissue leads to longer survival in Danish women with ovarian cancer. Results from the 'Malova' ovarian cancer study

AU - Heeran, Mel C

AU - Rask, Lene

AU - Høgdall, Claus K

AU - Kjaer, Susanne K

AU - Christensen, Lise

AU - Jensen, Allan

AU - Blaakaer, Jan

AU - Jarle Christensen, I B

AU - Høgdall, Estrid V S

PY - 2015/5/1

Y1 - 2015/5/1

N2 - The primary objective of this study was to analyse Tetranectin (TN) expression in tumour tissues and TN serum concentration in 758 women with epithelial ovarian tumours. The second was to evaluate, whether TN tissue expression levels correlate with clinico-pathological parameters and prognosis of the disease. Using tissue arrays we analysed the expression levels in tissues from 166 women with borderline ovarian tumours (BOTs) and 592 women with ovarian cancer (OC). A panel of three antibodies was used for immunohistochemistry: a polyclonal and two monoclonal antibodies. Serum TN was measured using the polyclonal antibody A-371. Univariate survival analyses stratified for chemotherapy showed that positive tissue TN as demonstrated by the polyclonal antibody indicated a significantly longer overall survival (OS) (p = 0.0001) as well as cancer specific survival (CSS) (p < 0.0001). High serum TN was likewise found to imply longer OS (p < 0.0001) and CSS (p < 0.0001), whereas tissue staining with the two monoclonal antibodies failed to demonstrate any significant correlation with either survival type. Univariate Kaplan-Meier survival analysis performed on all OC cases showed a significantly longer OS (p = 0.0009) and CSS (p = 0.0006) for women with TN positive tumour tissue and in women with high serum TN levels (p < 0.0001 for both). However, in the multivariate Cox regression analysis, only serum TN was found to be an independent prognostic factor for OS (p = 0.01) and not for CSS (p = 0.08). In conclusion, our results predict that a positive TN expression of both tumour tissue and serum points to a more favourable outcome for OC patients.

AB - The primary objective of this study was to analyse Tetranectin (TN) expression in tumour tissues and TN serum concentration in 758 women with epithelial ovarian tumours. The second was to evaluate, whether TN tissue expression levels correlate with clinico-pathological parameters and prognosis of the disease. Using tissue arrays we analysed the expression levels in tissues from 166 women with borderline ovarian tumours (BOTs) and 592 women with ovarian cancer (OC). A panel of three antibodies was used for immunohistochemistry: a polyclonal and two monoclonal antibodies. Serum TN was measured using the polyclonal antibody A-371. Univariate survival analyses stratified for chemotherapy showed that positive tissue TN as demonstrated by the polyclonal antibody indicated a significantly longer overall survival (OS) (p = 0.0001) as well as cancer specific survival (CSS) (p < 0.0001). High serum TN was likewise found to imply longer OS (p < 0.0001) and CSS (p < 0.0001), whereas tissue staining with the two monoclonal antibodies failed to demonstrate any significant correlation with either survival type. Univariate Kaplan-Meier survival analysis performed on all OC cases showed a significantly longer OS (p = 0.0009) and CSS (p = 0.0006) for women with TN positive tumour tissue and in women with high serum TN levels (p < 0.0001 for both). However, in the multivariate Cox regression analysis, only serum TN was found to be an independent prognostic factor for OS (p = 0.01) and not for CSS (p = 0.08). In conclusion, our results predict that a positive TN expression of both tumour tissue and serum points to a more favourable outcome for OC patients.

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KW - Aged

KW - Biomarkers, Tumor

KW - Denmark

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Immunohistochemistry

KW - Kaplan-Meier Estimate

KW - Lectins, C-Type

KW - Middle Aged

KW - Neoplasms, Glandular and Epithelial

KW - Ovarian Neoplasms

KW - Prognosis

KW - Risk Factors

U2 - 10.1111/apm.12368

DO - 10.1111/apm.12368

M3 - Journal article

C2 - 25846370

SN - 0903-4641

VL - 123

SP - 401

EP - 409

JO - APMIS : acta pathologica, microbiologica, et immunologica Scandinavica

JF - APMIS : acta pathologica, microbiologica, et immunologica Scandinavica

IS - 5

ER -

Tetranectin positive expression in tumour tissue leads to longer survival in Danish women with ovarian cancer. Results from the 'Malova' ovarian cancer study

Abstract

Keywords

UN SDGs

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