Abstract
Background and purpose - Currently, no clear evidence exists on the pattern of use of antithrombotics at admission in hip fracture patients and how this has changed over time. We investigated temporal trends in-and factors associated with-the use of antithrombotics in patients admitted with a fractured hip. Patients and methods - This was a population-based cohort study including all patients aged 18 years or above who were admitted with a hip fracture in Denmark from 1996 to 2012. The Danish national registries were used to collect information on medication use, vital status, and comorbidity. Results - From 1996 to 2012, the proportion of patients using antithrombotics in general increased by a factor of 2.3 from 19% to 43% (p < 0.001). More specifically, the use of anticoagulants increased by a factor of 6.8 and the use of antiplatelets increased by a factor of 2.1. When we adjusted for possible confounders, the use of antithrombotics still increased for every calendar year (relative risk (RR) = 1.03, CI: 1.03-1.04; p < 0.001). Age, sex, and Charlson comorbidity index were all associated with the use of antithrombotics (all p < 0.001). Interpretation - The proportion of hip fracture patients using antithrombotics at admission has increased substantially in Denmark over the last 2 decades. This highlights the need for evidence-based guidelines on how to handle patients using antithrombotics to ensure safe surgery and to avoid surgical delay.
| Original language | English |
|---|---|
| Journal | Acta Orthopaedica (Print Edition) |
| Volume | 87 |
| Issue number | 4 |
| Pages (from-to) | 368-73 |
| Number of pages | 6 |
| ISSN | 1745-3674 |
| DOIs | |
| Publication status | Published - Aug 2016 |
Keywords
- Aged
- Aged, 80 and over
- Anticoagulants
- Denmark
- Female
- Hip Fractures
- Humans
- Incidence
- Male
- Patient Admission
- Population Surveillance
- Registries
- Thrombosis
- Time Factors
- Journal Article
- Multicenter Study
- Observational Study