Temporal effects of maternal and pregnancy characteristics on serum PAPP-A and free β-hCG at 7-14 weeks' gestation

Susan Ball; Charlotte Ekelund; Dave Wright; Ida Sejersdahl Kirkegaard; Pernille Nørgaard; Olav Bjørn Petersen; Ann Tabor; and the Danish Fetal Medicine Study Group

doi:10.1002/uog.11209

Temporal effects of maternal and pregnancy characteristics on serum PAPP-A and free β-hCG at 7-14 weeks' gestation

Susan Ball, Charlotte Ekelund, Dave Wright, Ida Sejersdahl Kirkegaard, Pernille Nørgaard, Olav Bjørn Petersen, Ann Tabor, and the Danish Fetal Medicine Study Group

Department of Clinical Medicine

11 Citations (Scopus)

Abstract

Objective: Investigate gestational age dependent effects of racial origin, smoking status and mode of conception on maternal serum levels of free ß-human chorionic gonadotropin (β-hCG) and pregnancy associated plasma protein-A (PAPP-A) at 7-14 weeks' gestation. Methods: Data arise from prospective first-trimester combined screening for aneuploidies in singleton pregnancies, with serum free ß-hCG and PAPP-A measured at 7(+1) -14(+3) weeks' gestation. We include 27,908 pregnancies from three centres in the UK and 125,461 pregnancies from 22 centres in Denmark with normal fetal karyotype or birth of a phenotypically normal neonate. Multiple regression modelling of log(10) -transformed marker concentrations was used to produce log(10) multiple of the median (MoM) values for free β-hCG and PAPP-A and to examine pregnancy characteristics that have significant effects on marker concentrations. Results: Serum free ß-hCG and PAPP-A concentrations were significantly affected by gestational age, maternal weight, racial origin, parity, smoking and mode of conception. There were significant gestational age dependent effects of Afro-Caribbean race, smoking and IVF conception on PAPP-A and free ß-hCG levels. In women of Afro-Caribbean race there was a weekly increase in PAPP-A of 5.3% and in free ß-hCG of 1.8%. In smokers there was a weekly decrease in PAPP-A of 2.4% and in free β-hCG of 1.6%. In IVF conceptions there was a weekly increase in PAPP-A of 4.5% and in free ß-hCG of 4.6%. Conclusions: Serum free ß-hCG and PAPP-A concentrations at 7-14 weeks are affected by several pregnancy characteristics. The effects of Afro-Caribbean race, smoking and IVF conception change with gestational age. Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.

Original language	English
Journal	Ultrasound in Obstetrics & Gynecology
Volume	41
Issue number	1
Pages (from-to)	33-39
ISSN	0960-7692
DOIs	https://doi.org/10.1002/uog.11209
Publication status	Published - 2013

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10.1002/uog.11209

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@article{5b02c3f9cc58494695fd28dc2e83cf0e,

title = "Temporal effects of maternal and pregnancy characteristics on serum PAPP-A and free β-hCG at 7-14 weeks' gestation",

abstract = "Objective: Investigate gestational age dependent effects of racial origin, smoking status and mode of conception on maternal serum levels of free {\ss}-human chorionic gonadotropin (β-hCG) and pregnancy associated plasma protein-A (PAPP-A) at 7-14 weeks' gestation. Methods: Data arise from prospective first-trimester combined screening for aneuploidies in singleton pregnancies, with serum free {\ss}-hCG and PAPP-A measured at 7(+1) -14(+3) weeks' gestation. We include 27,908 pregnancies from three centres in the UK and 125,461 pregnancies from 22 centres in Denmark with normal fetal karyotype or birth of a phenotypically normal neonate. Multiple regression modelling of log(10) -transformed marker concentrations was used to produce log(10) multiple of the median (MoM) values for free β-hCG and PAPP-A and to examine pregnancy characteristics that have significant effects on marker concentrations. Results: Serum free {\ss}-hCG and PAPP-A concentrations were significantly affected by gestational age, maternal weight, racial origin, parity, smoking and mode of conception. There were significant gestational age dependent effects of Afro-Caribbean race, smoking and IVF conception on PAPP-A and free {\ss}-hCG levels. In women of Afro-Caribbean race there was a weekly increase in PAPP-A of 5.3% and in free {\ss}-hCG of 1.8%. In smokers there was a weekly decrease in PAPP-A of 2.4% and in free β-hCG of 1.6%. In IVF conceptions there was a weekly increase in PAPP-A of 4.5% and in free {\ss}-hCG of 4.6%. Conclusions: Serum free {\ss}-hCG and PAPP-A concentrations at 7-14 weeks are affected by several pregnancy characteristics. The effects of Afro-Caribbean race, smoking and IVF conception change with gestational age. Copyright {\textcopyright} 2012 ISUOG. Published by John Wiley & Sons, Ltd.",

author = "Susan Ball and Charlotte Ekelund and Dave Wright and Kirkegaard, {Ida Sejersdahl} and Pernille N{\o}rgaard and {Bj{\o}rn Petersen}, Olav and Ann Tabor and Ann Tabor",

note = "Copyright {\textcopyright} 2012 ISUOG. Published by John Wiley & Sons, Ltd.",

year = "2013",

doi = "10.1002/uog.11209",

language = "English",

volume = "41",

pages = "33--39",

journal = "Ultrasound in Obstetrics & Gynecology",

issn = "0960-7692",

publisher = "JohnWiley & Sons Ltd",

number = "1",

}

TY - JOUR

T1 - Temporal effects of maternal and pregnancy characteristics on serum PAPP-A and free β-hCG at 7-14 weeks' gestation

AU - Ball, Susan

AU - Ekelund, Charlotte

AU - Wright, Dave

AU - Kirkegaard, Ida Sejersdahl

AU - Nørgaard, Pernille

AU - Bjørn Petersen, Olav

AU - Tabor, Ann

AU - and the Danish Fetal Medicine Study Group

PY - 2013

Y1 - 2013

N2 - Objective: Investigate gestational age dependent effects of racial origin, smoking status and mode of conception on maternal serum levels of free ß-human chorionic gonadotropin (β-hCG) and pregnancy associated plasma protein-A (PAPP-A) at 7-14 weeks' gestation. Methods: Data arise from prospective first-trimester combined screening for aneuploidies in singleton pregnancies, with serum free ß-hCG and PAPP-A measured at 7(+1) -14(+3) weeks' gestation. We include 27,908 pregnancies from three centres in the UK and 125,461 pregnancies from 22 centres in Denmark with normal fetal karyotype or birth of a phenotypically normal neonate. Multiple regression modelling of log(10) -transformed marker concentrations was used to produce log(10) multiple of the median (MoM) values for free β-hCG and PAPP-A and to examine pregnancy characteristics that have significant effects on marker concentrations. Results: Serum free ß-hCG and PAPP-A concentrations were significantly affected by gestational age, maternal weight, racial origin, parity, smoking and mode of conception. There were significant gestational age dependent effects of Afro-Caribbean race, smoking and IVF conception on PAPP-A and free ß-hCG levels. In women of Afro-Caribbean race there was a weekly increase in PAPP-A of 5.3% and in free ß-hCG of 1.8%. In smokers there was a weekly decrease in PAPP-A of 2.4% and in free β-hCG of 1.6%. In IVF conceptions there was a weekly increase in PAPP-A of 4.5% and in free ß-hCG of 4.6%. Conclusions: Serum free ß-hCG and PAPP-A concentrations at 7-14 weeks are affected by several pregnancy characteristics. The effects of Afro-Caribbean race, smoking and IVF conception change with gestational age. Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.

AB - Objective: Investigate gestational age dependent effects of racial origin, smoking status and mode of conception on maternal serum levels of free ß-human chorionic gonadotropin (β-hCG) and pregnancy associated plasma protein-A (PAPP-A) at 7-14 weeks' gestation. Methods: Data arise from prospective first-trimester combined screening for aneuploidies in singleton pregnancies, with serum free ß-hCG and PAPP-A measured at 7(+1) -14(+3) weeks' gestation. We include 27,908 pregnancies from three centres in the UK and 125,461 pregnancies from 22 centres in Denmark with normal fetal karyotype or birth of a phenotypically normal neonate. Multiple regression modelling of log(10) -transformed marker concentrations was used to produce log(10) multiple of the median (MoM) values for free β-hCG and PAPP-A and to examine pregnancy characteristics that have significant effects on marker concentrations. Results: Serum free ß-hCG and PAPP-A concentrations were significantly affected by gestational age, maternal weight, racial origin, parity, smoking and mode of conception. There were significant gestational age dependent effects of Afro-Caribbean race, smoking and IVF conception on PAPP-A and free ß-hCG levels. In women of Afro-Caribbean race there was a weekly increase in PAPP-A of 5.3% and in free ß-hCG of 1.8%. In smokers there was a weekly decrease in PAPP-A of 2.4% and in free β-hCG of 1.6%. In IVF conceptions there was a weekly increase in PAPP-A of 4.5% and in free ß-hCG of 4.6%. Conclusions: Serum free ß-hCG and PAPP-A concentrations at 7-14 weeks are affected by several pregnancy characteristics. The effects of Afro-Caribbean race, smoking and IVF conception change with gestational age. Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.

U2 - 10.1002/uog.11209

DO - 10.1002/uog.11209

M3 - Journal article

SN - 0960-7692

VL - 41

SP - 33

EP - 39

JO - Ultrasound in Obstetrics & Gynecology

JF - Ultrasound in Obstetrics & Gynecology

IS - 1

ER -

Temporal effects of maternal and pregnancy characteristics on serum PAPP-A and free β-hCG at 7-14 weeks' gestation

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