Temporal changes of new-onset atrial fibrillation in patients randomized to surgical or transcatheter aortic valve replacement

TY - JOUR

T1 - Temporal changes of new-onset atrial fibrillation in patients randomized to surgical or transcatheter aortic valve replacement

AU - Jørgensen, Troels Højsgaard

AU - Thyregod, Hans Gustav Hørsted

AU - Tarp, Julie Bjerre

AU - Svendsen, Jesper Hastrup

AU - Søndergaard, Lars

N1 - Copyright © 2017 Elsevier B.V. All rights reserved.

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Background Temporal development of new-onset atrial fibrillation (NOAF) after aortic valve replacement is unclear, and opportunistic screening has limited diagnostic accuracy. This is the first study to investigate the incidence and temporal development of NOAF detected by implantable loop recorder (ILR) in patients with aortic stenosis, randomized to surgical aortic valve replacement (SAVR) or transcatheter aortic valve replacement (TAVR). Method An ILR was implanted in a subgroup of patients without pre-procedural atrial fibrillation (AF), randomized to SAVR or TAVR in the NOTION trial. Data from the ILR were transmitted in intervals of 2 weeks for 12 weeks post-procedurally and analyzed. Results The study included 25 and 27 patients who underwent SAVR and TAVR, respectively. The cumulative rate of NOAF was 100% and 81.5% for patients undergoing SAVR and TAVR, respectively (P = 0.06). TAVR patients without NOAF 6 weeks post-procedurally remained free from NOAF. The prevalence of AF after SAVR decreased significantly after 8 weeks when compared with the first 2 weeks (50.0% vs. 84.0%, respectively; P < 0.05). The prevalence of AF after TAVR did not change significantly during follow-up. The median AF burden (percentage of time with AF) was 2.8% and 0.04% during the first 2 weeks after SAVR and TAVR, respectively (P = 0.01) and it decreased significantly over time after SAVR but not after TAVR. Conclusion NOAF subsided 6 weeks after TAVR. AF prevalence and burden decreased significantly over time after SAVR, but remained stable after TAVR. These findings may be considered for post-procedural anti-coagulation strategy.

AB - Background Temporal development of new-onset atrial fibrillation (NOAF) after aortic valve replacement is unclear, and opportunistic screening has limited diagnostic accuracy. This is the first study to investigate the incidence and temporal development of NOAF detected by implantable loop recorder (ILR) in patients with aortic stenosis, randomized to surgical aortic valve replacement (SAVR) or transcatheter aortic valve replacement (TAVR). Method An ILR was implanted in a subgroup of patients without pre-procedural atrial fibrillation (AF), randomized to SAVR or TAVR in the NOTION trial. Data from the ILR were transmitted in intervals of 2 weeks for 12 weeks post-procedurally and analyzed. Results The study included 25 and 27 patients who underwent SAVR and TAVR, respectively. The cumulative rate of NOAF was 100% and 81.5% for patients undergoing SAVR and TAVR, respectively (P = 0.06). TAVR patients without NOAF 6 weeks post-procedurally remained free from NOAF. The prevalence of AF after SAVR decreased significantly after 8 weeks when compared with the first 2 weeks (50.0% vs. 84.0%, respectively; P < 0.05). The prevalence of AF after TAVR did not change significantly during follow-up. The median AF burden (percentage of time with AF) was 2.8% and 0.04% during the first 2 weeks after SAVR and TAVR, respectively (P = 0.01) and it decreased significantly over time after SAVR but not after TAVR. Conclusion NOAF subsided 6 weeks after TAVR. AF prevalence and burden decreased significantly over time after SAVR, but remained stable after TAVR. These findings may be considered for post-procedural anti-coagulation strategy.

KW - Aged

KW - Aged, 80 and over

KW - Aortic Valve

KW - Aortic Valve Stenosis

KW - Atrial Fibrillation

KW - Female

KW - Heart Valve Prosthesis Implantation

KW - Humans

KW - Male

KW - Postoperative Complications

KW - Prevalence

KW - Risk Factors

KW - Severity of Illness Index

KW - Statistics as Topic

KW - Time Factors

KW - Transcatheter Aortic Valve Replacement

KW - Treatment Outcome

KW - Journal Article

KW - Randomized Controlled Trial

U2 - 10.1016/j.ijcard.2017.02.098

DO - 10.1016/j.ijcard.2017.02.098

M3 - Journal article

C2 - 28258844

SN - 0167-5273

VL - 234

SP - 16

EP - 21

JO - International Journal of Cardiology

JF - International Journal of Cardiology

ER -