Taurine protects DNA of lymphocytes against oxidative alteration in riding horses

Janusz Leszek Sokól; Ewa Sawosz; Tomasz Niemiec; Katarzyna Majchrzak; Szczepan Chrzanowski; Anna Lojek; André Chwalibog

Taurine protects DNA of lymphocytes against oxidative alteration in riding horses

Janusz Leszek Sokól, Ewa Sawosz, Tomasz Niemiec, Katarzyna Majchrzak, Szczepan Chrzanowski, Anna Lojek, André Chwalibog

4 Citations (Scopus)

Abstract

The study aimed at evaluation the effect of dietary supplement of taurine on the oxidation-reduction status in riding horses, and especially on the extent of oxidative DNA degradation in lymphocytes. Ten Thoroughbred and half-bred geldings aged 6-13 years were classified according to breed and amount of work done into two groups - control (C, n=5) and experimental (E, n=5), the latter fed the diet with addition of 40 g taurine/horse/day. Blood samples were withdrawn from the horses' jugular vein before commencing the riding season and then after 30 days of working. In the blood some selected morphological and biochemical indicators were determined including the TBA-RS and 8-oxo-dG in lymphocyte DNA. It was found that physical effort of horses, being used for 30 days in recreation riding, affected homeostasis of redox status, and especially the rate of oxidative DNA degradation of lymphocytes. The addition of taurine to feed caused smaller oxidative stress, manifested by lower concentration of TBA-RS in plasma and of 8-oxo-dG in lymphocytes. The taurine lowered the lipid peroxidation intensity that occurred in horses due to the oxidative stress caused by physical effort. Furthermore, taurine revealed affinity to nucleic acids, counteracted the oxidative DNA degradation and decreased the damages of DNA in lymphocytes.

Original language	English
Journal	Animal Science Papers and Reports
Volume	27
Issue number	1
Pages (from-to)	33-40
Number of pages	8
ISSN	0860-4037
Publication status	Published - 2009

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@article{d3123cc071e911de8bc9000ea68e967b,

title = "Taurine protects DNA of lymphocytes against oxidative alteration in riding horses",

abstract = "The study aimed at evaluation the effect of dietary supplement of taurine on the oxidation-reduction status in riding horses, and especially on the extent of oxidative DNA degradation in lymphocytes. Ten Thoroughbred and half-bred geldings aged 6-13 years were classified according to breed and amount of work done into two groups - control (C, n=5) and experimental (E, n=5), the latter fed the diet with addition of 40 g taurine/horse/day. Blood samples were withdrawn from the horses' jugular vein before commencing the riding season and then after 30 days of working. In the blood some selected morphological and biochemical indicators were determined including the TBA-RS and 8-oxo-dG in lymphocyte DNA. It was found that physical effort of horses, being used for 30 days in recreation riding, affected homeostasis of redox status, and especially the rate of oxidative DNA degradation of lymphocytes. The addition of taurine to feed caused smaller oxidative stress, manifested by lower concentration of TBA-RS in plasma and of 8-oxo-dG in lymphocytes. The taurine lowered the lipid peroxidation intensity that occurred in horses due to the oxidative stress caused by physical effort. Furthermore, taurine revealed affinity to nucleic acids, counteracted the oxidative DNA degradation and decreased the damages of DNA in lymphocytes.",

author = "Sok{\'o}l, {Janusz Leszek} and Ewa Sawosz and Tomasz Niemiec and Katarzyna Majchrzak and Szczepan Chrzanowski and Anna Lojek and Andr{\'e} Chwalibog",

year = "2009",

language = "English",

volume = "27",

pages = "33--40",

journal = "Animal Science Papers and Reports",

issn = "0860-4037",

publisher = "Polska Akademia Nauk Instytut Genetyki i Hodowli Zwierzat",

number = "1",

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TY - JOUR

T1 - Taurine protects DNA of lymphocytes against oxidative alteration in riding horses

AU - Sokól, Janusz Leszek

AU - Sawosz, Ewa

AU - Niemiec, Tomasz

AU - Majchrzak, Katarzyna

AU - Chrzanowski, Szczepan

AU - Lojek, Anna

AU - Chwalibog, André

PY - 2009

Y1 - 2009

N2 - The study aimed at evaluation the effect of dietary supplement of taurine on the oxidation-reduction status in riding horses, and especially on the extent of oxidative DNA degradation in lymphocytes. Ten Thoroughbred and half-bred geldings aged 6-13 years were classified according to breed and amount of work done into two groups - control (C, n=5) and experimental (E, n=5), the latter fed the diet with addition of 40 g taurine/horse/day. Blood samples were withdrawn from the horses' jugular vein before commencing the riding season and then after 30 days of working. In the blood some selected morphological and biochemical indicators were determined including the TBA-RS and 8-oxo-dG in lymphocyte DNA. It was found that physical effort of horses, being used for 30 days in recreation riding, affected homeostasis of redox status, and especially the rate of oxidative DNA degradation of lymphocytes. The addition of taurine to feed caused smaller oxidative stress, manifested by lower concentration of TBA-RS in plasma and of 8-oxo-dG in lymphocytes. The taurine lowered the lipid peroxidation intensity that occurred in horses due to the oxidative stress caused by physical effort. Furthermore, taurine revealed affinity to nucleic acids, counteracted the oxidative DNA degradation and decreased the damages of DNA in lymphocytes.

AB - The study aimed at evaluation the effect of dietary supplement of taurine on the oxidation-reduction status in riding horses, and especially on the extent of oxidative DNA degradation in lymphocytes. Ten Thoroughbred and half-bred geldings aged 6-13 years were classified according to breed and amount of work done into two groups - control (C, n=5) and experimental (E, n=5), the latter fed the diet with addition of 40 g taurine/horse/day. Blood samples were withdrawn from the horses' jugular vein before commencing the riding season and then after 30 days of working. In the blood some selected morphological and biochemical indicators were determined including the TBA-RS and 8-oxo-dG in lymphocyte DNA. It was found that physical effort of horses, being used for 30 days in recreation riding, affected homeostasis of redox status, and especially the rate of oxidative DNA degradation of lymphocytes. The addition of taurine to feed caused smaller oxidative stress, manifested by lower concentration of TBA-RS in plasma and of 8-oxo-dG in lymphocytes. The taurine lowered the lipid peroxidation intensity that occurred in horses due to the oxidative stress caused by physical effort. Furthermore, taurine revealed affinity to nucleic acids, counteracted the oxidative DNA degradation and decreased the damages of DNA in lymphocytes.

M3 - Journal article

SN - 0860-4037

VL - 27

SP - 33

EP - 40

JO - Animal Science Papers and Reports

JF - Animal Science Papers and Reports

IS - 1

ER -

Taurine protects DNA of lymphocytes against oxidative alteration in riding horses

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