Targeting ECM Disrupts Cancer Progression

TY - JOUR

T1 - Targeting ECM Disrupts Cancer Progression

AU - Venning, Freja A

AU - Wullkopf, Lena

AU - Erler, Janine T

PY - 2015

Y1 - 2015

N2 - Metastatic complications are responsible for more than 90% of cancer-related deaths. The progression from an isolated tumor to disseminated metastatic disease is a multistep process, with each step involving intricate cross talk between the cancer cells and their non-cellular surroundings, the extracellular matrix (ECM). Many ECM proteins are significantly deregulated during the progression of cancer, causing both biochemical and biomechanical changes that together promote the metastatic cascade. In this review, the influence of several ECM proteins on these multiple steps of cancer spread is summarized. In addition, we highlight the promising (pre-)clinical data showing benefits of targeting these ECM macromolecules to prevent cancer progression.

AB - Metastatic complications are responsible for more than 90% of cancer-related deaths. The progression from an isolated tumor to disseminated metastatic disease is a multistep process, with each step involving intricate cross talk between the cancer cells and their non-cellular surroundings, the extracellular matrix (ECM). Many ECM proteins are significantly deregulated during the progression of cancer, causing both biochemical and biomechanical changes that together promote the metastatic cascade. In this review, the influence of several ECM proteins on these multiple steps of cancer spread is summarized. In addition, we highlight the promising (pre-)clinical data showing benefits of targeting these ECM macromolecules to prevent cancer progression.

U2 - 10.3389/fonc.2015.00224

DO - 10.3389/fonc.2015.00224

M3 - Review

C2 - 26539408

SN - 2234-943X

VL - 5

SP - 224

JO - Frontiers in Oncology

JF - Frontiers in Oncology

ER -