Targeted microbubbles for imaging tumor angiogenesis: assessment of whole-body biodistribution with dynamic micro-PET in mice

Jürgen K Willmann; Zhen Cheng; Corrine Davis; Amelie M Lutz; Meike L Schipper; Carsten Haagen Nielsen; Sanjiv S Gambhir

doi:10.1148/radiol.2491072050

Targeted microbubbles for imaging tumor angiogenesis: assessment of whole-body biodistribution with dynamic micro-PET in mice

Jürgen K Willmann, Zhen Cheng, Corrine Davis, Amelie M Lutz, Meike L Schipper, Carsten Haagen Nielsen, Sanjiv S Gambhir

Cluster for Molecular Imaging

136 Citations (Scopus)

Abstract

To evaluate in vivo whole-body biodistribution of microbubbles (MBs) targeted to tumor angiogenesis-related vascular endothelial growth factor (VEGF) receptor 2 (VEGFR2) by using dynamic micro-positron emission tomography (PET) in living mice.

Original language	English
Journal	Radiology
Volume	249
Issue number	1
Pages (from-to)	212-9
Number of pages	8
ISSN	0033-8419
DOIs	https://doi.org/10.1148/radiol.2491072050
Publication status	Published - 2008

Keywords

Animals
Antibodies
Benzoates
Fluorescent Antibody Technique
Fluorocarbons
Hemangiosarcoma
Liver
Mice
Mice, Nude
Microbubbles
Neoplasms, Experimental
Neovascularization, Pathologic
Positron-Emission Tomography
Spleen
Succinimides
Tissue Distribution
Vascular Endothelial Growth Factor Receptor-2

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10.1148/radiol.2491072050

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title = "Targeted microbubbles for imaging tumor angiogenesis: assessment of whole-body biodistribution with dynamic micro-PET in mice",

abstract = "To evaluate in vivo whole-body biodistribution of microbubbles (MBs) targeted to tumor angiogenesis-related vascular endothelial growth factor (VEGF) receptor 2 (VEGFR2) by using dynamic micro-positron emission tomography (PET) in living mice.",

keywords = "Animals, Antibodies, Benzoates, Fluorescent Antibody Technique, Fluorocarbons, Hemangiosarcoma, Liver, Mice, Mice, Nude, Microbubbles, Neoplasms, Experimental, Neovascularization, Pathologic, Positron-Emission Tomography, Spleen, Succinimides, Tissue Distribution, Vascular Endothelial Growth Factor Receptor-2",

author = "Willmann, {J{\"u}rgen K} and Zhen Cheng and Corrine Davis and Lutz, {Amelie M} and Schipper, {Meike L} and Nielsen, {Carsten Haagen} and Gambhir, {Sanjiv S}",

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year = "2008",

doi = "10.1148/radiol.2491072050",

language = "English",

volume = "249",

pages = "212--9",

journal = "Radiology",

issn = "0033-8419",

publisher = "Radiological Society of North America, Inc.",

number = "1",

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TY - JOUR

T1 - Targeted microbubbles for imaging tumor angiogenesis: assessment of whole-body biodistribution with dynamic micro-PET in mice

AU - Willmann, Jürgen K

AU - Cheng, Zhen

AU - Davis, Corrine

AU - Lutz, Amelie M

AU - Schipper, Meike L

AU - Nielsen, Carsten Haagen

AU - Gambhir, Sanjiv S

N1 - (c) RSNA, 2008.

PY - 2008

Y1 - 2008

N2 - To evaluate in vivo whole-body biodistribution of microbubbles (MBs) targeted to tumor angiogenesis-related vascular endothelial growth factor (VEGF) receptor 2 (VEGFR2) by using dynamic micro-positron emission tomography (PET) in living mice.

AB - To evaluate in vivo whole-body biodistribution of microbubbles (MBs) targeted to tumor angiogenesis-related vascular endothelial growth factor (VEGF) receptor 2 (VEGFR2) by using dynamic micro-positron emission tomography (PET) in living mice.

KW - Animals

KW - Antibodies

KW - Benzoates

KW - Fluorescent Antibody Technique

KW - Fluorocarbons

KW - Hemangiosarcoma

KW - Liver

KW - Mice

KW - Mice, Nude

KW - Microbubbles

KW - Neoplasms, Experimental

KW - Neovascularization, Pathologic

KW - Positron-Emission Tomography

KW - Spleen

KW - Succinimides

KW - Tissue Distribution

KW - Vascular Endothelial Growth Factor Receptor-2

U2 - 10.1148/radiol.2491072050

DO - 10.1148/radiol.2491072050

M3 - Journal article

C2 - 18695212

SN - 0033-8419

VL - 249

SP - 212

EP - 219

JO - Radiology

JF - Radiology

IS - 1

ER -

Targeted microbubbles for imaging tumor angiogenesis: assessment of whole-body biodistribution with dynamic micro-PET in mice

Abstract

Keywords

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