Tandem neopentyl glycol maltosides (TNMs) for membrane protein stabilisation

Hyoung Eun Bae; Jonas S Mortensen; Orquidea Ribeiro; Yang Du; Muhammad Ehsan; Brian K Kobilka; Claus J Loland; Bernadette Byrne; Pil Seok Chae

doi:10.1039/c6cc06147h

Tandem neopentyl glycol maltosides (TNMs) for membrane protein stabilisation

Hyoung Eun Bae, Jonas S Mortensen, Orquidea Ribeiro, Yang Du, Muhammad Ehsan, Brian K Kobilka, Claus J Loland, Bernadette Byrne, Pil Seok Chae

Neuropharm and Genetics

9 Citations (Scopus)

Abstract

A novel class of detergents, designated tandem neopentyl glycol maltosides (TNMs), were evaluated with four target membrane proteins. The best detergent varied depending on the target, but TNM-C12L and TNM-C11S were notable for their ability to confer increased membrane protein stability compared to DDM. These agents have potential for use in membrane protein research.

Original language	English
Journal	Chemical communications (Cambridge, England)
Volume	52
Issue number	81
Pages (from-to)	12104-12107
Number of pages	4
ISSN	1359-7345
DOIs	https://doi.org/10.1039/c6cc06147h
Publication status	Published - 4 Oct 2016

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title = "Tandem neopentyl glycol maltosides (TNMs) for membrane protein stabilisation",

abstract = "A novel class of detergents, designated tandem neopentyl glycol maltosides (TNMs), were evaluated with four target membrane proteins. The best detergent varied depending on the target, but TNM-C12L and TNM-C11S were notable for their ability to confer increased membrane protein stability compared to DDM. These agents have potential for use in membrane protein research.",

author = "Bae, {Hyoung Eun} and Mortensen, {Jonas S} and Orquidea Ribeiro and Yang Du and Muhammad Ehsan and Kobilka, {Brian K} and Loland, {Claus J} and Bernadette Byrne and Chae, {Pil Seok}",

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AU - Bae, Hyoung Eun

AU - Mortensen, Jonas S

AU - Ribeiro, Orquidea

AU - Du, Yang

AU - Ehsan, Muhammad

AU - Kobilka, Brian K

AU - Loland, Claus J

AU - Byrne, Bernadette

AU - Chae, Pil Seok

PY - 2016/10/4

Y1 - 2016/10/4

N2 - A novel class of detergents, designated tandem neopentyl glycol maltosides (TNMs), were evaluated with four target membrane proteins. The best detergent varied depending on the target, but TNM-C12L and TNM-C11S were notable for their ability to confer increased membrane protein stability compared to DDM. These agents have potential for use in membrane protein research.

AB - A novel class of detergents, designated tandem neopentyl glycol maltosides (TNMs), were evaluated with four target membrane proteins. The best detergent varied depending on the target, but TNM-C12L and TNM-C11S were notable for their ability to confer increased membrane protein stability compared to DDM. These agents have potential for use in membrane protein research.

U2 - 10.1039/c6cc06147h

DO - 10.1039/c6cc06147h

M3 - Journal article

C2 - 27711401

SN - 1359-7345

VL - 52

SP - 12104

EP - 12107

JO - Chemical Communications

JF - Chemical Communications

IS - 81

ER -

Tandem neopentyl glycol maltosides (TNMs) for membrane protein stabilisation

Abstract

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