Tandem Facial Amphiphiles for Membrane Protein Stabilization

Pil Seok Chae; Kamil Gotfryd; Jennifer Pacyna; Larry J W Miercke; Søren G F Rasmussen; Rebecca A Robbins; Rohini R Rana; Claus Juul Løland; Brian Kobilka; Robert Stroud; Bernadette Byrne; Ulrik Gether; Samuel H Gellman

doi:10.1021/ja1072959

Tandem Facial Amphiphiles for Membrane Protein Stabilization

Pil Seok Chae, Kamil Gotfryd, Jennifer Pacyna, Larry J W Miercke, Søren G F Rasmussen, Rebecca A Robbins, Rohini R Rana, Claus Juul Løland, Brian Kobilka, Robert Stroud, Bernadette Byrne, Ulrik Gether, Samuel H Gellman

74 Citations (Scopus)

Abstract

We describe a new type of synthetic amphiphile that is intended to support biochemical characterization of intrinsic membrane proteins. Members of this new family displayed favorable behavior with four of five membrane proteins tested, and these amphiphiles formed relatively small micelles.

Original language	English
Journal	Journal of the American Chemical Society
Volume	132
Issue number	47
Pages (from-to)	16750-2
Number of pages	3
ISSN	0002-7863
DOIs	https://doi.org/10.1021/ja1072959
Publication status	Published - 1 Dec 2010

Access to Document

10.1021/ja1072959

Cite this

@article{3bd94a20ecc611dfb6d2000ea68e967b,

title = "Tandem Facial Amphiphiles for Membrane Protein Stabilization",

abstract = "We describe a new type of synthetic amphiphile that is intended to support biochemical characterization of intrinsic membrane proteins. Members of this new family displayed favorable behavior with four of five membrane proteins tested, and these amphiphiles formed relatively small micelles.",

author = "Chae, {Pil Seok} and Kamil Gotfryd and Jennifer Pacyna and Miercke, {Larry J W} and Rasmussen, {S{\o}ren G F} and Robbins, {Rebecca A} and Rana, {Rohini R} and L{\o}land, {Claus Juul} and Brian Kobilka and Robert Stroud and Bernadette Byrne and Ulrik Gether and Gellman, {Samuel H}",

year = "2010",

month = dec,

day = "1",

doi = "10.1021/ja1072959",

language = "English",

volume = "132",

pages = "16750--2",

journal = "Journal of the American Chemical Society",

issn = "0002-7863",

publisher = "ACS Publications",

number = "47",

}

TY - JOUR

T1 - Tandem Facial Amphiphiles for Membrane Protein Stabilization

AU - Chae, Pil Seok

AU - Gotfryd, Kamil

AU - Pacyna, Jennifer

AU - Miercke, Larry J W

AU - Rasmussen, Søren G F

AU - Robbins, Rebecca A

AU - Rana, Rohini R

AU - Løland, Claus Juul

AU - Kobilka, Brian

AU - Stroud, Robert

AU - Byrne, Bernadette

AU - Gether, Ulrik

AU - Gellman, Samuel H

PY - 2010/12/1

Y1 - 2010/12/1

N2 - We describe a new type of synthetic amphiphile that is intended to support biochemical characterization of intrinsic membrane proteins. Members of this new family displayed favorable behavior with four of five membrane proteins tested, and these amphiphiles formed relatively small micelles.

AB - We describe a new type of synthetic amphiphile that is intended to support biochemical characterization of intrinsic membrane proteins. Members of this new family displayed favorable behavior with four of five membrane proteins tested, and these amphiphiles formed relatively small micelles.

U2 - 10.1021/ja1072959

DO - 10.1021/ja1072959

M3 - Journal article

C2 - 21049926

SN - 0002-7863

VL - 132

SP - 16750

EP - 16752

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 47

ER -

Tandem Facial Amphiphiles for Membrane Protein Stabilization

Abstract

Access to Document

Fingerprint

Cite this