Abstract
During chromosome analysis the finding of few cells with X-chromosome aneuploidy in a phenotypically normal woman is not unusual - so-called low-grade mosaicism for X aneuploidy (LLX-A). Such results can be difficult to interpret. In this review, LLX-A and its clinical implications are discussed, and based on the current literature it can be concluded, that LLX-A is an age-related phenomenon not related to reproductive issues such as recurrent abortions. This should be taken into account in any laboratory performing chromosome analysis.
| Translated title of the contribution | X-chromosome loss can be an age-related phenomenon in women |
|---|---|
| Original language | Danish |
| Article number | V10170731 |
| Journal | Ugeskrift for Laeger |
| Volume | 180 |
| Issue number | 23 |
| Number of pages | 4 |
| ISSN | 0041-5782 |
| Publication status | Published - 2018 |