T-type Ca(2+) channels and Autoregulation of Local Blood Flow

Lars Jørn Jensen; Morten Schak Nielsen; Max Salomonsson; Charlotte Mehlin Sørensen

doi:10.1080/19336950.2016.1273997

T-type Ca(2+) channels and Autoregulation of Local Blood Flow

Lars Jørn Jensen, Morten Schak Nielsen, Max Salomonsson, Charlotte Mehlin Sørensen

6 Citations (Scopus)

Abstract

L-type voltage gated Ca(2+) channels are considered to be the primary source of calcium influx during the myogenic response. However, many vascular beds also express T-type voltage gated Ca(2+) channels. Recent studies suggest that these channels may also play a role in autoregulation. At low pressures (40-80 mm Hg) T-type channels affect myogenic responses in cerebral and mesenteric vascular beds. T-type channels also seem to be involved in skeletal muscle autoregulation. This review discusses the expression and role of T-type voltage gated Ca(2+) channels in the autoregulation of several different vascular beds. Lack of specific pharmacological inhibitors has been a huge challenge in the field. Now the research has been strengthened by genetically modified models such as mice lacking expression of T-type voltage gated Ca(2+) channels (CaV3.1 and CaV3.2). Hopefully, these new tools will help further elucidate the role of voltage gated T-type Ca(2+) channels in autoregulation and vascular function.

Original language	English
Journal	Channels (Austin)
Volume	11
Issue number	3
Pages (from-to)	183-195
Number of pages	13
ISSN	1933-6950
DOIs	https://doi.org/10.1080/19336950.2016.1273997
Publication status	Published - 4 May 2017

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title = "T-type Ca(2+) channels and Autoregulation of Local Blood Flow",

abstract = "L-type voltage gated Ca(2+) channels are considered to be the primary source of calcium influx during the myogenic response. However, many vascular beds also express T-type voltage gated Ca(2+) channels. Recent studies suggest that these channels may also play a role in autoregulation. At low pressures (40-80 mm Hg) T-type channels affect myogenic responses in cerebral and mesenteric vascular beds. T-type channels also seem to be involved in skeletal muscle autoregulation. This review discusses the expression and role of T-type voltage gated Ca(2+) channels in the autoregulation of several different vascular beds. Lack of specific pharmacological inhibitors has been a huge challenge in the field. Now the research has been strengthened by genetically modified models such as mice lacking expression of T-type voltage gated Ca(2+) channels (CaV3.1 and CaV3.2). Hopefully, these new tools will help further elucidate the role of voltage gated T-type Ca(2+) channels in autoregulation and vascular function.",

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T1 - T-type Ca(2+) channels and Autoregulation of Local Blood Flow

AU - Jensen, Lars Jørn

AU - Nielsen, Morten Schak

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AU - Sørensen, Charlotte Mehlin

PY - 2017/5/4

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N2 - L-type voltage gated Ca(2+) channels are considered to be the primary source of calcium influx during the myogenic response. However, many vascular beds also express T-type voltage gated Ca(2+) channels. Recent studies suggest that these channels may also play a role in autoregulation. At low pressures (40-80 mm Hg) T-type channels affect myogenic responses in cerebral and mesenteric vascular beds. T-type channels also seem to be involved in skeletal muscle autoregulation. This review discusses the expression and role of T-type voltage gated Ca(2+) channels in the autoregulation of several different vascular beds. Lack of specific pharmacological inhibitors has been a huge challenge in the field. Now the research has been strengthened by genetically modified models such as mice lacking expression of T-type voltage gated Ca(2+) channels (CaV3.1 and CaV3.2). Hopefully, these new tools will help further elucidate the role of voltage gated T-type Ca(2+) channels in autoregulation and vascular function.

AB - L-type voltage gated Ca(2+) channels are considered to be the primary source of calcium influx during the myogenic response. However, many vascular beds also express T-type voltage gated Ca(2+) channels. Recent studies suggest that these channels may also play a role in autoregulation. At low pressures (40-80 mm Hg) T-type channels affect myogenic responses in cerebral and mesenteric vascular beds. T-type channels also seem to be involved in skeletal muscle autoregulation. This review discusses the expression and role of T-type voltage gated Ca(2+) channels in the autoregulation of several different vascular beds. Lack of specific pharmacological inhibitors has been a huge challenge in the field. Now the research has been strengthened by genetically modified models such as mice lacking expression of T-type voltage gated Ca(2+) channels (CaV3.1 and CaV3.2). Hopefully, these new tools will help further elucidate the role of voltage gated T-type Ca(2+) channels in autoregulation and vascular function.

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T-type Ca(2+) channels and Autoregulation of Local Blood Flow

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