T-cell responses in malaria

TY - JOUR

T1 - T-cell responses in malaria

AU - Hviid, L

AU - Jakobsen, P H

AU - Abu-Zeid, Y A

AU - Theander, T G

N1 - Keywords: Amino Acid Sequence; Animals; Antigens, Protozoan; Humans; Immunity, Cellular; Malaria; Malaria, Falciparum; Molecular Sequence Data; T-Lymphocytes

PY - 1992

Y1 - 1992

N2 - Malaria is caused by infection with protozoan parasites of the genus Plasmodium. It remains one of the most severe health problems in tropical regions of the world, and the rapid spread of resistance to drugs and insecticides has stimulated intensive research aimed at the development of a malaria vaccine. Despite this, no efficient operative vaccine is currently available. A large amount of information on T-cell responses to malaria antigens has been accumulated, concerning antigens derived from all stages of the parasite life cycle. The present review summarizes some of that information, and discusses factors affecting the responses of T cells to malaria antigens.

AB - Malaria is caused by infection with protozoan parasites of the genus Plasmodium. It remains one of the most severe health problems in tropical regions of the world, and the rapid spread of resistance to drugs and insecticides has stimulated intensive research aimed at the development of a malaria vaccine. Despite this, no efficient operative vaccine is currently available. A large amount of information on T-cell responses to malaria antigens has been accumulated, concerning antigens derived from all stages of the parasite life cycle. The present review summarizes some of that information, and discusses factors affecting the responses of T cells to malaria antigens.

M3 - Journal article

C2 - 1554496

SN - 0903-4641

VL - 100

SP - 95

EP - 106

JO - Acta Pathologica Microbiologica et Immunologica Scandinavica

JF - Acta Pathologica Microbiologica et Immunologica Scandinavica

IS - 2

ER -