T-cell ALL in ataxia telangiectasia cured with only 7 weeks of anti-leukemic therapy

Ditte S Hersby; Astrid Sehested; Kim Kristensen; K. Schmiegelow

doi:10.1097/MPH.0000000000000151

T-cell ALL in ataxia telangiectasia cured with only 7 weeks of anti-leukemic therapy

Ditte S Hersby, Astrid Sehested, Kim Kristensen, K. Schmiegelow

Department of Clinical Medicine

2 Citations (Scopus)

Abstract

A 20-month-old girl diagnosed with T-cell acute lymphoblastic leukemia was treated according to the Nordic NOPHO ALL2000 protocol. The patient developed severe immunosuppression and experienced life-threatening adenovirus infection, which was treated with ribavirin and cidofovir. α-fetoprotein was 20- to 30-fold elevated, and genetic analysis confirmed the diagnosis of ataxia telangiectasia. Despite receiving only 7 weeks of anti-leukemic therapy, she has stayed in first remission now 8 years after the diagnosis. We speculate that this could be because of increased chemosensitivity of ATM-mutated leukemic cells, adenovirus causing a direct oncolytic effect, and/or high levels of endogenous cortisol during her severe infection.

Original language	English
Journal	Journal of Pediatric Hematology/Oncology
Volume	37
Issue number	2
Pages (from-to)	154-5
Number of pages	2
ISSN	1077-4114
DOIs	https://doi.org/10.1097/MPH.0000000000000151
Publication status	Published - 6 Mar 2015

Keywords

Adenoviridae
Adenovirus Infections, Human
Antiviral Agents
Ataxia Telangiectasia
Female
Humans
Infant
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Prognosis
Remission Induction

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10.1097/MPH.0000000000000151

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title = "T-cell ALL in ataxia telangiectasia cured with only 7 weeks of anti-leukemic therapy",

abstract = "A 20-month-old girl diagnosed with T-cell acute lymphoblastic leukemia was treated according to the Nordic NOPHO ALL2000 protocol. The patient developed severe immunosuppression and experienced life-threatening adenovirus infection, which was treated with ribavirin and cidofovir. α-fetoprotein was 20- to 30-fold elevated, and genetic analysis confirmed the diagnosis of ataxia telangiectasia. Despite receiving only 7 weeks of anti-leukemic therapy, she has stayed in first remission now 8 years after the diagnosis. We speculate that this could be because of increased chemosensitivity of ATM-mutated leukemic cells, adenovirus causing a direct oncolytic effect, and/or high levels of endogenous cortisol during her severe infection.",

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T1 - T-cell ALL in ataxia telangiectasia cured with only 7 weeks of anti-leukemic therapy

AU - Hersby, Ditte S

AU - Sehested, Astrid

AU - Kristensen, Kim

AU - Schmiegelow, K.

PY - 2015/3/6

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KW - Adenoviridae

KW - Adenovirus Infections, Human

KW - Antiviral Agents

KW - Ataxia Telangiectasia

KW - Female

KW - Humans

KW - Infant

KW - Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

KW - Prognosis

KW - Remission Induction

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T-cell ALL in ataxia telangiectasia cured with only 7 weeks of anti-leukemic therapy

Abstract

Keywords

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