Systolic heart failure: a prothrombotic state

Olav R de Peuter; Wouter E M Kok; Christian Torp-Pedersen; Harry R Büller; Pieter W Kamphuisen; Olav R de Peuter; Wouter E M Kok; Christian Torp-Pedersen; Harry R Büller; Pieter W Kamphuisen

doi:10.1055/s-0029-1234145

Systolic heart failure: a prothrombotic state

Olav R de Peuter, Wouter E M Kok, Christian Torp-Pedersen, Harry R Büller, Pieter W Kamphuisen, Olav R de Peuter, Wouter E M Kok, Christian Torp-Pedersen, Harry R Büller, Pieter W Kamphuisen

26 Citations (Scopus)

Abstract

Systolic heart failure is a common syndrome whose incidence is expected to increase. Several treatment modalities, such as beta-blockers and angiotensin-converting enzyme inhibitors, improve survival. Whether antithrombotic treatment is effective remains to be elucidated, although observations suggest a prothrombotic state in heart failure. This article focuses on this prothrombotic state and discusses the risk of thromboembolic events, pathophysiological mechanisms, and the potential role of anticoagulant treatment.

Original language	English
Journal	Seminars in Thrombosis and Hemostasis
Volume	35
Issue number	5
Pages (from-to)	497-504
Number of pages	8
ISSN	0094-6176
DOIs	https://doi.org/10.1055/s-0029-1234145 https://doi.org/10.1055/s-0029-1234145
Publication status	Published - 1 Jul 2009

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title = "Systolic heart failure: a prothrombotic state",

abstract = "Systolic heart failure is a common syndrome whose incidence is expected to increase. Several treatment modalities, such as beta-blockers and angiotensin-converting enzyme inhibitors, improve survival. Whether antithrombotic treatment is effective remains to be elucidated, although observations suggest a prothrombotic state in heart failure. This article focuses on this prothrombotic state and discusses the risk of thromboembolic events, pathophysiological mechanisms, and the potential role of anticoagulant treatment.",

author = "{de Peuter}, {Olav R} and Kok, {Wouter E M} and Christian Torp-Pedersen and B{\"u}ller, {Harry R} and Kamphuisen, {Pieter W} and {de Peuter}, {Olav R} and Kok, {Wouter E M} and Christian Torp-Pedersen and B{\"u}ller, {Harry R} and Kamphuisen, {Pieter W}",

note = "Keywords: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anticoagulants; Aspirin; Fibrinolytic Agents; Heart Failure, Systolic; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Prognosis; Pulmonary Embolism; Randomized Controlled Trials as Topic; Receptors, Angiotensin; Renin-Angiotensin System; Thromboembolism; Warfarin",

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doi = "10.1055/s-0029-1234145",

language = "English",

volume = "35",

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T1 - Systolic heart failure: a prothrombotic state

AU - de Peuter, Olav R

AU - Kok, Wouter E M

AU - Torp-Pedersen, Christian

AU - Büller, Harry R

AU - Kamphuisen, Pieter W

AU - de Peuter, Olav R

AU - Kok, Wouter E M

AU - Torp-Pedersen, Christian

AU - Büller, Harry R

AU - Kamphuisen, Pieter W

N1 - Keywords: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anticoagulants; Aspirin; Fibrinolytic Agents; Heart Failure, Systolic; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Prognosis; Pulmonary Embolism; Randomized Controlled Trials as Topic; Receptors, Angiotensin; Renin-Angiotensin System; Thromboembolism; Warfarin

PY - 2009/7/1

Y1 - 2009/7/1

N2 - Systolic heart failure is a common syndrome whose incidence is expected to increase. Several treatment modalities, such as beta-blockers and angiotensin-converting enzyme inhibitors, improve survival. Whether antithrombotic treatment is effective remains to be elucidated, although observations suggest a prothrombotic state in heart failure. This article focuses on this prothrombotic state and discusses the risk of thromboembolic events, pathophysiological mechanisms, and the potential role of anticoagulant treatment.

AB - Systolic heart failure is a common syndrome whose incidence is expected to increase. Several treatment modalities, such as beta-blockers and angiotensin-converting enzyme inhibitors, improve survival. Whether antithrombotic treatment is effective remains to be elucidated, although observations suggest a prothrombotic state in heart failure. This article focuses on this prothrombotic state and discusses the risk of thromboembolic events, pathophysiological mechanisms, and the potential role of anticoagulant treatment.

U2 - 10.1055/s-0029-1234145

DO - 10.1055/s-0029-1234145

M3 - Journal article

C2 - 19739040

SN - 0094-6176

VL - 35

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EP - 504

JO - Seminars in Thrombosis and Hemostasis

JF - Seminars in Thrombosis and Hemostasis

IS - 5

ER -

Systolic heart failure: a prothrombotic state

Abstract

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