Abstract
We tested the hypothesis that moderate increases in endogenous angiotensin II (Ang II) concentrations, induced by withdrawal of angiotensin converting enzyme inhibition (ACE-I) in patients with compensated heart failure (HF) on chronic medical therapy, do not increase or impair control of systemic vascular resistance (SVR). SVR was determined in supine and seated positions in 12 HF patients [NYHA class II-III; ejection fraction=0.29 +/- 0.03 (mean +/- SE)] and 9 control subjects. HF patients were investigated during high (n=11; withdrawal of ACE-I treatment for 24 h) and low (n=9; sustained ACE-I therapy) endogenous plasma Ang II concentrations. Withdrawal of ACE-I therapy in HF caused moderately increased Ang II concentrations of 30 +/- 5 pg/ml compared with 12 +/- 2 pg/ml in controls (p
| Original language | English |
|---|---|
| Journal | Scandinavian Journal of Clinical & Laboratory Investigation |
| Volume | 62 |
| Issue number | 4 |
| Pages (from-to) | 245-54 |
| Number of pages | 10 |
| ISSN | 0036-5513 |
| Publication status | Published - 1 Jan 2002 |
Keywords
- Angiotensin-Converting Enzyme Inhibitors
- Baroreflex
- Blood Pressure
- Cardiac Output
- Heart Failure
- Humans
- Male
- Middle Aged
- Posture
- Substance Withdrawal Syndrome
- Sympathetic Nervous System
- Vascular Resistance