Systemic treatment with epidermal growth factor in pigs induces ductal proliferations in the pancreas

Lars Vinter-Jensen; C O Juhl; P S Teglbjaerg; Steen Seier Poulsen; E Z Dajani; Ebba Nexø

Systemic treatment with epidermal growth factor in pigs induces ductal proliferations in the pancreas

Lars Vinter-Jensen, C O Juhl, P S Teglbjaerg, Steen Seier Poulsen, E Z Dajani, Ebba Nexø

Endocrinology and Metabolism

31 Citations (Scopus)

Abstract

Epidermal growth factor (EGF), transforming growth factor alpha (TGF-alpha), and the EGF receptor are often overexpressed in chronic pancreatitis and in malignant pancreatic growth. Transgenic mice overexpressing TGF-alpha develop tissue changes in the pancrease resembling changes found in chronic pancreatitis. The effects of systemic treatment with EGF on the porcine pancrease were investigated in this study.

Original language	English
Journal	Gastroenterology
Volume	113
Issue number	4
Pages (from-to)	1367-1374
Number of pages	8
ISSN	0016-5085
Publication status	Published - Oct 1997

Keywords

Animals
Cell Division
Cytoplasmic Granules
Epidermal Growth Factor
Epithelial Cells
Epithelium
Female
Glycoconjugates
Islets of Langerhans
Male
Mice
Mice, Transgenic
Mucins
Pancreatic Ducts
Pancreatic Polypeptide
Proliferating Cell Nuclear Antigen
Somatostatin
Swine
Swine, Miniature

Cite this

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title = "Systemic treatment with epidermal growth factor in pigs induces ductal proliferations in the pancreas",

abstract = "Epidermal growth factor (EGF), transforming growth factor alpha (TGF-alpha), and the EGF receptor are often overexpressed in chronic pancreatitis and in malignant pancreatic growth. Transgenic mice overexpressing TGF-alpha develop tissue changes in the pancrease resembling changes found in chronic pancreatitis. The effects of systemic treatment with EGF on the porcine pancrease were investigated in this study.",

keywords = "Animals, Cell Division, Cytoplasmic Granules, Epidermal Growth Factor, Epithelial Cells, Epithelium, Female, Glycoconjugates, Islets of Langerhans, Male, Mice, Mice, Transgenic, Mucins, Pancreatic Ducts, Pancreatic Polypeptide, Proliferating Cell Nuclear Antigen, Somatostatin, Swine, Swine, Miniature",

author = "Lars Vinter-Jensen and Juhl, {C O} and Teglbjaerg, {P S} and Poulsen, {Steen Seier} and Dajani, {E Z} and Ebba Nex{\o}",

year = "1997",

month = oct,

language = "English",

volume = "113",

pages = "1367--1374",

journal = "Gastroenterology",

issn = "0016-5085",

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TY - JOUR

T1 - Systemic treatment with epidermal growth factor in pigs induces ductal proliferations in the pancreas

AU - Vinter-Jensen, Lars

AU - Juhl, C O

AU - Teglbjaerg, P S

AU - Poulsen, Steen Seier

AU - Dajani, E Z

AU - Nexø, Ebba

PY - 1997/10

Y1 - 1997/10

N2 - Epidermal growth factor (EGF), transforming growth factor alpha (TGF-alpha), and the EGF receptor are often overexpressed in chronic pancreatitis and in malignant pancreatic growth. Transgenic mice overexpressing TGF-alpha develop tissue changes in the pancrease resembling changes found in chronic pancreatitis. The effects of systemic treatment with EGF on the porcine pancrease were investigated in this study.

AB - Epidermal growth factor (EGF), transforming growth factor alpha (TGF-alpha), and the EGF receptor are often overexpressed in chronic pancreatitis and in malignant pancreatic growth. Transgenic mice overexpressing TGF-alpha develop tissue changes in the pancrease resembling changes found in chronic pancreatitis. The effects of systemic treatment with EGF on the porcine pancrease were investigated in this study.

KW - Animals

KW - Cell Division

KW - Cytoplasmic Granules

KW - Epidermal Growth Factor

KW - Epithelial Cells

KW - Epithelium

KW - Female

KW - Glycoconjugates

KW - Islets of Langerhans

KW - Male

KW - Mice

KW - Mice, Transgenic

KW - Mucins

KW - Pancreatic Ducts

KW - Pancreatic Polypeptide

KW - Proliferating Cell Nuclear Antigen

KW - Somatostatin

KW - Swine

KW - Swine, Miniature

M3 - Journal article

C2 - 9322532

SN - 0016-5085

VL - 113

SP - 1367

EP - 1374

JO - Gastroenterology

JF - Gastroenterology

IS - 4

ER -

Systemic treatment with epidermal growth factor in pigs induces ductal proliferations in the pancreas

Abstract

Keywords

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