Systemic T-cell activation in acute clinically isolated optic neuritis.

TY - JOUR

T1 - Systemic T-cell activation in acute clinically isolated optic neuritis.

AU - Roed, Hanne

AU - Frederiksen, Jette

AU - Langkilde, Annika Reynberg

AU - Sørensen, Torben Lykke

AU - Lauritzen, Martin

AU - Sellebjerg, Finn

PY - 2005

Y1 - 2005

N2 - We examined untreated 60 patients with acute monosymptomatic optic neuritis (ON). Patients examined early after onset showed increased expression of HLA-DR and CD45R0 on CD4 and CD8 T cells. Expression of HLA-DR on CD4 T cells was higher in patients without IgG oligoclonal bands. Expression of HLA-DR on CD4 and CD8 T cells correlated negatively with measures of disease activity and positively with measures of good visual function, and expression of CD45R0 on CD4 T cells correlated negatively with measures of disease activity. We hypothesize that HLA-DR expression may characterize a protective T-cell subset in ON

AB - We examined untreated 60 patients with acute monosymptomatic optic neuritis (ON). Patients examined early after onset showed increased expression of HLA-DR and CD45R0 on CD4 and CD8 T cells. Expression of HLA-DR on CD4 T cells was higher in patients without IgG oligoclonal bands. Expression of HLA-DR on CD4 and CD8 T cells correlated negatively with measures of disease activity and positively with measures of good visual function, and expression of CD45R0 on CD4 T cells correlated negatively with measures of disease activity. We hypothesize that HLA-DR expression may characterize a protective T-cell subset in ON

M3 - Journal article

SN - 0165-5728

VL - 162

SP - 165

EP - 172

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -