Systemic oxidative DNA and RNA damage are not increased during early phases of psychosis: A case control study

TY - JOUR

T1 - Systemic oxidative DNA and RNA damage are not increased during early phases of psychosis

T2 - A case control study

AU - Nordholm, Dorte

AU - Poulsen, Henrik Enghusen

AU - Hjorthøj, Carsten

AU - Randers, Lasse

AU - Nielsen, Mette Ø.

AU - Wulff, Sanne

AU - Krakauer, Kristine

AU - Nørbak-Emig, Henrik

AU - Henriksen, Trine

AU - Glenthøj, Birte

AU - Nordentoft, Merete

N1 - Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

PY - 2016/7/30

Y1 - 2016/7/30

N2 - It has been suggested that patients with schizophrenia develop higher levels of oxidative stress, which may contribute to deteriorating mental illness. In order to examine oxidative stress in the early stages of severe mental illness, we examined the levels of systemic Deoxyribonucleic Acid (DNA) and Ribonucleic Acid (RNA) oxidation, 8-oxo-7,8-dihydro-2'-deoxyguanosine and 8-oxo-7,8-dihydroguanosine, perceived stress and recent life events in patients at ultra high-risk (UHR) of developing psychosis, in antipsychotic naïve patients with first-episode schizophrenia (FES), and in healthy controls. We included 41 UHR patients, 35 FES patients, and 29 healthy controls. There was no difference in the level of DNA/RNA oxidative damage between UHR patients and FES patients compared with healthy controls. We found no association between levels of DNA/RNA oxidative damage and perceived stress/life events. Based on the results, we suggest that DNA and RNA oxidative markers are not increased during the early stages of illness, but further longitudinal studies in first-episode psychosis should be carried out to examine whether DNA and RNA oxidative damage are potential markers of severe illness.

AB - It has been suggested that patients with schizophrenia develop higher levels of oxidative stress, which may contribute to deteriorating mental illness. In order to examine oxidative stress in the early stages of severe mental illness, we examined the levels of systemic Deoxyribonucleic Acid (DNA) and Ribonucleic Acid (RNA) oxidation, 8-oxo-7,8-dihydro-2'-deoxyguanosine and 8-oxo-7,8-dihydroguanosine, perceived stress and recent life events in patients at ultra high-risk (UHR) of developing psychosis, in antipsychotic naïve patients with first-episode schizophrenia (FES), and in healthy controls. We included 41 UHR patients, 35 FES patients, and 29 healthy controls. There was no difference in the level of DNA/RNA oxidative damage between UHR patients and FES patients compared with healthy controls. We found no association between levels of DNA/RNA oxidative damage and perceived stress/life events. Based on the results, we suggest that DNA and RNA oxidative markers are not increased during the early stages of illness, but further longitudinal studies in first-episode psychosis should be carried out to examine whether DNA and RNA oxidative damage are potential markers of severe illness.

KW - Journal Article

U2 - 10.1016/j.psychres.2016.04.062

DO - 10.1016/j.psychres.2016.04.062

M3 - Journal article

C2 - 27183105

SN - 0165-1781

VL - 241

SP - 201

EP - 206

JO - Psychiatry Research

JF - Psychiatry Research

ER -