Synovitis assessed on static and dynamic contrast-enhanced magnetic resonance imaging and its association with pain in knee osteoarthritis: A cross-sectional study

TY - JOUR

T1 - Synovitis assessed on static and dynamic contrast-enhanced magnetic resonance imaging and its association with pain in knee osteoarthritis

T2 - A cross-sectional study

AU - Riis, Robert Gabriel Coumine

AU - Gudbergsen, Henrik

AU - Henriksen, Marius

AU - Ballegaard, Christine

AU - Bandak, Elisabeth

AU - Röttger, Diana

AU - Bliddal, Henning

AU - Hansen, Bjarke Brandt

AU - Hangaard, Stine

AU - Boesen, Mikael

N1 - Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Objectives To investigate the association between pain and peripatellar-synovitis on static and dynamic contrast-enhanced MRI in knee osteoarthritis. Methods In a cross-sectional setting, knee synovitis was assessed using 3-Tesla MRI and correlated with pain using the knee injury and osteoarthritis outcome score (KOOS). Synovitis was assessed in the peripatellar recesses with: (i) dynamic contrast-enhanced (DCE)-MRI, using both pharmacokinetic and heuristic models, (ii) contrast-enhanced (CE)-MRI, and (iii) non-CE-MRI. The DCE-MRI variable IRExNvoxel was chosen as the primary variable in the analyses. Results Valid data were available in 94 persons with a mean age of 65 years, a BMI of 32.3 kg/m2 and a mean Kellgren-Lawrence grade of 2.5. IRExNvoxel showed a statically significant correlation with KOOS-Pain (r = -0.34; p = 0.001), as was the case with all DCE-variables but one. Correlations between static MRI-variables and KOOS-Pain ranged between -0.21 < r < -0.29 (p < 0.040). Intraclass correlation coefficients ranged between 0.90-0.99 for the heuristic and 0.66-0.93 for the pharmacokinetic DCE-MRI variables. Conclusions The results confirm an association between peripatellar-synovitis and pain in KOA. Overall, DCE-MRI showed stronger correlations with KOOS-Pain compared to static MRI. DCE-MRI analyses were highly reproducible and have the potential to be used to further investigate the role of inflammation and perfusion in KOA.

AB - Objectives To investigate the association between pain and peripatellar-synovitis on static and dynamic contrast-enhanced MRI in knee osteoarthritis. Methods In a cross-sectional setting, knee synovitis was assessed using 3-Tesla MRI and correlated with pain using the knee injury and osteoarthritis outcome score (KOOS). Synovitis was assessed in the peripatellar recesses with: (i) dynamic contrast-enhanced (DCE)-MRI, using both pharmacokinetic and heuristic models, (ii) contrast-enhanced (CE)-MRI, and (iii) non-CE-MRI. The DCE-MRI variable IRExNvoxel was chosen as the primary variable in the analyses. Results Valid data were available in 94 persons with a mean age of 65 years, a BMI of 32.3 kg/m2 and a mean Kellgren-Lawrence grade of 2.5. IRExNvoxel showed a statically significant correlation with KOOS-Pain (r = -0.34; p = 0.001), as was the case with all DCE-variables but one. Correlations between static MRI-variables and KOOS-Pain ranged between -0.21 < r < -0.29 (p < 0.040). Intraclass correlation coefficients ranged between 0.90-0.99 for the heuristic and 0.66-0.93 for the pharmacokinetic DCE-MRI variables. Conclusions The results confirm an association between peripatellar-synovitis and pain in KOA. Overall, DCE-MRI showed stronger correlations with KOOS-Pain compared to static MRI. DCE-MRI analyses were highly reproducible and have the potential to be used to further investigate the role of inflammation and perfusion in KOA.

KW - Aged

KW - Contrast Media

KW - Cross-Sectional Studies

KW - Female

KW - Gadolinium

KW - Heterocyclic Compounds

KW - Humans

KW - Image Enhancement

KW - Image Processing, Computer-Assisted

KW - Knee Joint

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Organometallic Compounds

KW - Osteoarthritis, Knee

KW - Pain Measurement

KW - Patella

KW - Reproducibility of Results

KW - Self Report

KW - Synovitis

KW - Comparative Study

KW - Journal Article

U2 - 10.1016/j.ejrad.2016.03.017

DO - 10.1016/j.ejrad.2016.03.017

M3 - Journal article

C2 - 27161058

SN - 0720-048X

VL - 85

SP - 1099

EP - 1108

JO - European Journal of Radiology

JF - European Journal of Radiology

IS - 6

ER -