Syncytin immunoreactivity in colorectal cancer: Potential prognostic impact

Julie Mou Larsen; Ib Jarle Christensen; Hans Jørgen Nielsen; Ulla Hansen; Bolette Bjerregaard; Jan Fredrik Talts; Lars-Inge Larsson

doi:http://dx.doi.org/10.1016/j.canlet.2009.02.008

Syncytin immunoreactivity in colorectal cancer: Potential prognostic impact

Julie Mou Larsen, Ib Jarle Christensen, Hans Jørgen Nielsen, Ulla Hansen, Bolette Bjerregaard, Jan Fredrik Talts, Lars-Inge Larsson

Department of Clinical Medicine

32 Citations (Scopus)

Abstract

The endogenous retroviral envelope protein syncytin is involved in cell fusions and has also been associated with immunomodulatory functions. Syncytin is currently known to be expressed in the placenta, testis and brain as well as in breast and endometrial carcinomas. Using a newly developed monoclonal syncytin antibody we have assessed syncytin expression in a retrospective series of 140 colorectal cancer patients. Variable degrees of syncytin expression were detected in both colonic and rectal tumors and the prognostic impact of such expression was analysed with the Kaplan-Meier method and the Cox proportional hazard model. Interestingly, increased syncytin expression was associated with decreased overall survival in rectal but not in colonic cancer patients. Thus, the prognostic impact of syncytin expression appears to vary with the tumor type.

Original language	English
Journal	Cancer Letters
Volume	280
Issue number	1
Pages (from-to)	44-9
ISSN	0304-3835
DOIs	https://doi.org/10.1016/j.canlet.2009.02.008
Publication status	Published - 2009

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title = "Syncytin immunoreactivity in colorectal cancer: Potential prognostic impact",

abstract = "The endogenous retroviral envelope protein syncytin is involved in cell fusions and has also been associated with immunomodulatory functions. Syncytin is currently known to be expressed in the placenta, testis and brain as well as in breast and endometrial carcinomas. Using a newly developed monoclonal syncytin antibody we have assessed syncytin expression in a retrospective series of 140 colorectal cancer patients. Variable degrees of syncytin expression were detected in both colonic and rectal tumors and the prognostic impact of such expression was analysed with the Kaplan-Meier method and the Cox proportional hazard model. Interestingly, increased syncytin expression was associated with decreased overall survival in rectal but not in colonic cancer patients. Thus, the prognostic impact of syncytin expression appears to vary with the tumor type.",

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T1 - Syncytin immunoreactivity in colorectal cancer: Potential prognostic impact

AU - Larsen, Julie Mou

AU - Christensen, Ib Jarle

AU - Nielsen, Hans Jørgen

AU - Hansen, Ulla

AU - Bjerregaard, Bolette

AU - Talts, Jan Fredrik

AU - Larsson, Lars-Inge

PY - 2009

Y1 - 2009

N2 - The endogenous retroviral envelope protein syncytin is involved in cell fusions and has also been associated with immunomodulatory functions. Syncytin is currently known to be expressed in the placenta, testis and brain as well as in breast and endometrial carcinomas. Using a newly developed monoclonal syncytin antibody we have assessed syncytin expression in a retrospective series of 140 colorectal cancer patients. Variable degrees of syncytin expression were detected in both colonic and rectal tumors and the prognostic impact of such expression was analysed with the Kaplan-Meier method and the Cox proportional hazard model. Interestingly, increased syncytin expression was associated with decreased overall survival in rectal but not in colonic cancer patients. Thus, the prognostic impact of syncytin expression appears to vary with the tumor type.

AB - The endogenous retroviral envelope protein syncytin is involved in cell fusions and has also been associated with immunomodulatory functions. Syncytin is currently known to be expressed in the placenta, testis and brain as well as in breast and endometrial carcinomas. Using a newly developed monoclonal syncytin antibody we have assessed syncytin expression in a retrospective series of 140 colorectal cancer patients. Variable degrees of syncytin expression were detected in both colonic and rectal tumors and the prognostic impact of such expression was analysed with the Kaplan-Meier method and the Cox proportional hazard model. Interestingly, increased syncytin expression was associated with decreased overall survival in rectal but not in colonic cancer patients. Thus, the prognostic impact of syncytin expression appears to vary with the tumor type.

U2 - http://dx.doi.org/10.1016/j.canlet.2009.02.008

DO - http://dx.doi.org/10.1016/j.canlet.2009.02.008

M3 - Journal article

SN - 0304-3835

VL - 280

SP - 44

EP - 49

JO - Cancer Letters

JF - Cancer Letters

IS - 1

ER -

Syncytin immunoreactivity in colorectal cancer: Potential prognostic impact

Abstract

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