Synchronized renal blood flow dynamics mapped with wavelet analysis of laser speckle flowmetry data

TY - JOUR

T1 - Synchronized renal blood flow dynamics mapped with wavelet analysis of laser speckle flowmetry data

AU - Brazhe, Alexey R

AU - Marsh, Donald J

AU - von Holstein-Rathlou, Niels-Henrik

AU - Sosnovtseva, Olga

PY - 2014/9

Y1 - 2014/9

N2 - Full-field laser speckle microscopy provides real-time imaging of superficial blood flow rate. Here we apply continuous wavelet transform to time series of speckle-estimated blood flow from each pixel of the images to map synchronous patterns in instantaneous frequency and phase on the surface of rat kidneys. The regulatory mechanism in the renal microcirculation generates oscillations in arterial blood flow at several characteristic frequencies. Our approach to laser speckle image processing allows detection of frequency and phase entrainments, visualization of their patterns, and estimation of the extent of synchronization in renal cortex dynamics.

AB - Full-field laser speckle microscopy provides real-time imaging of superficial blood flow rate. Here we apply continuous wavelet transform to time series of speckle-estimated blood flow from each pixel of the images to map synchronous patterns in instantaneous frequency and phase on the surface of rat kidneys. The regulatory mechanism in the renal microcirculation generates oscillations in arterial blood flow at several characteristic frequencies. Our approach to laser speckle image processing allows detection of frequency and phase entrainments, visualization of their patterns, and estimation of the extent of synchronization in renal cortex dynamics.

U2 - 10.1371/journal.pone.0105879

DO - 10.1371/journal.pone.0105879

M3 - Journal article

C2 - 25216274

SN - 1932-6203

VL - 9

SP - 1

EP - 9

JO - PLoS Computational Biology

JF - PLoS Computational Biology

IS - 9

M1 - e105879

ER -