Abstract
As emphasized in several of the preceding chapters, rhythmic activity is a characteristic behavioral pattern for living systems. At the cellular level, this type of activity manifests itself as a sequence of more or less regular spikes in neuron membrane potentials, as bursting patterns for insulin releasing beta-cells, and as oscillations in the intra-cellular calcium concentration for smooth muscle cells in the vascular resistance vessels. The physiological level also displays a variety of processes that exhibit oscillatory behavior, including breathing and the beating of the heart [9, 14], and at the genetic level each individual cell disposes of mechanisms to generate the 24-h circadian rhythm [8].
Original language | English |
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Title of host publication | Biosimulation in Biomedical Research, Health Care and Drug Development |
Editors | Erik Mosekilde, Olga Sosnovtseva, Amin Rostami-Hodjegan |
Publisher | Springer |
Publication date | 1 Jan 2014 |
Pages | 285-310 |
ISBN (Print) | 978-3-7091-0417-0 |
DOIs | |
Publication status | Published - 1 Jan 2014 |