Synaptopathies: synaptic dysfunction in neurological disorders - A review from students to students

Katarzyna Lepeta; Mychael V Lourenco; Barbara C Schweitzer; Pamela V Martino Adami; Priyanjalee Banerjee; Silvina Catuara-Solarz; Mario de La Fuente Revenga; Alain Marc Guillem; Mouna Haidar; Omamuyovwi M Ijomone; Bettina Nadorp; Lin Qi; Nirma D Perera; Louise K Refsgaard; Kimberley M Reid; Mariam Sabbar; Arghyadip Sahoo; Natascha Schaefer; Rebecca K Sheean; Anna Suska; Rajkumar Verma; Cinzia Vicidomini; Dean Wright; Xing-Ding Zhang; Constanze Seidenbecher

doi:10.1111/jnc.13713

Synaptopathies: synaptic dysfunction in neurological disorders - A review from students to students

Katarzyna Lepeta, Mychael V Lourenco, Barbara C Schweitzer, Pamela V Martino Adami, Priyanjalee Banerjee, Silvina Catuara-Solarz, Mario de La Fuente Revenga, Alain Marc Guillem, Mouna Haidar, Omamuyovwi M Ijomone, Bettina Nadorp, Lin Qi, Nirma D Perera, Louise K Refsgaard, Kimberley M Reid, Mariam Sabbar, Arghyadip Sahoo, Natascha Schaefer, Rebecca K Sheean, Anna SuskaRajkumar Verma, Cinzia Vicidomini, Dean Wright, Xing-Ding Zhang, Constanze Seidenbecher

103 Citations (Scopus)

Abstract

Abstract: Synapses are essential components of neurons and allow information to travel coordinately throughout the nervous system to adjust behavior to environmental stimuli and to control body functions, memories, and emotions. Thus, optimal synaptic communication is required for proper brain physiology, and slight perturbations of synapse function can lead to brain disorders. In fact, increasing evidence has demonstrated the relevance of synapse dysfunction as a major determinant of many neurological diseases. This notion has led to the concept of synaptopathies as brain diseases with synapse defects as shared pathogenic features. In this review, which was initiated at the 13th International Society for Neurochemistry Advanced School, we discuss basic concepts of synapse structure and function, and provide a critical view of how aberrant synapse physiology may contribute to neurodevelopmental disorders (autism, Down syndrome, startle disease, and epilepsy) as well as neurodegenerative disorders (Alzheimer and Parkinson disease). We finally discuss the appropriateness and potential implications of gathering synapse diseases under a single term. Understanding common causes and intrinsic differences in disease-associated synaptic dysfunction could offer novel clues toward synapse-based therapeutic intervention for neurological and neuropsychiatric disorders. (Figure presented.) In this Review, which was initiated at the 13th International Society for Neurochemistry (ISN) Advanced School, we discuss basic concepts of synapse structure and function, and provide a critical view of how aberrant synapse physiology may contribute to neurodevelopmental (autism, Down syndrome, startle disease, and epilepsy) as well as neurodegenerative disorders (Alzheimer's and Parkinson's diseases), gathered together under the term of synaptopathies. Read the Editorial Highlight for this article on page 783.

Original language	English
Journal	Journal of Neurochemistry
Volume	138
Issue number	6
Pages (from-to)	785-805
Number of pages	21
ISSN	0022-3042
DOIs	https://doi.org/10.1111/jnc.13713
Publication status	Published - 1 Sept 2016

Keywords

Journal Article
Review

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10.1111/jnc.13713

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Lepeta, K., Lourenco, M. V., Schweitzer, B. C., Martino Adami, P. V., Banerjee, P., Catuara-Solarz, S., de La Fuente Revenga, M., Guillem, A. M., Haidar, M., Ijomone, O. M., Nadorp, B., Qi, L., Perera, N. D., Refsgaard, L. K., Reid, K. M., Sabbar, M., Sahoo, A., Schaefer, N., Sheean, R. K., ... Seidenbecher, C. (2016). Synaptopathies: synaptic dysfunction in neurological disorders - A review from students to students. Journal of Neurochemistry, 138(6), 785-805. https://doi.org/10.1111/jnc.13713

Lepeta, K, Lourenco, MV, Schweitzer, BC, Martino Adami, PV, Banerjee, P, Catuara-Solarz, S, de La Fuente Revenga, M, Guillem, AM, Haidar, M, Ijomone, OM, Nadorp, B, Qi, L, Perera, ND, Refsgaard, LK, Reid, KM, Sabbar, M, Sahoo, A, Schaefer, N, Sheean, RK, Suska, A, Verma, R, Vicidomini, C, Wright, D, Zhang, X-D & Seidenbecher, C 2016, 'Synaptopathies: synaptic dysfunction in neurological disorders - A review from students to students', Journal of Neurochemistry, vol. 138, no. 6, pp. 785-805. https://doi.org/10.1111/jnc.13713

@article{2e0c2051aa384c41938b5b2adbeaa916,

title = "Synaptopathies: synaptic dysfunction in neurological disorders - A review from students to students",

abstract = "Abstract: Synapses are essential components of neurons and allow information to travel coordinately throughout the nervous system to adjust behavior to environmental stimuli and to control body functions, memories, and emotions. Thus, optimal synaptic communication is required for proper brain physiology, and slight perturbations of synapse function can lead to brain disorders. In fact, increasing evidence has demonstrated the relevance of synapse dysfunction as a major determinant of many neurological diseases. This notion has led to the concept of synaptopathies as brain diseases with synapse defects as shared pathogenic features. In this review, which was initiated at the 13th International Society for Neurochemistry Advanced School, we discuss basic concepts of synapse structure and function, and provide a critical view of how aberrant synapse physiology may contribute to neurodevelopmental disorders (autism, Down syndrome, startle disease, and epilepsy) as well as neurodegenerative disorders (Alzheimer and Parkinson disease). We finally discuss the appropriateness and potential implications of gathering synapse diseases under a single term. Understanding common causes and intrinsic differences in disease-associated synaptic dysfunction could offer novel clues toward synapse-based therapeutic intervention for neurological and neuropsychiatric disorders. (Figure presented.) In this Review, which was initiated at the 13th International Society for Neurochemistry (ISN) Advanced School, we discuss basic concepts of synapse structure and function, and provide a critical view of how aberrant synapse physiology may contribute to neurodevelopmental (autism, Down syndrome, startle disease, and epilepsy) as well as neurodegenerative disorders (Alzheimer's and Parkinson's diseases), gathered together under the term of synaptopathies. Read the Editorial Highlight for this article on page 783.",

keywords = "Journal Article, Review",

author = "Katarzyna Lepeta and Lourenco, {Mychael V} and Schweitzer, {Barbara C} and {Martino Adami}, {Pamela V} and Priyanjalee Banerjee and Silvina Catuara-Solarz and {de La Fuente Revenga}, Mario and Guillem, {Alain Marc} and Mouna Haidar and Ijomone, {Omamuyovwi M} and Bettina Nadorp and Lin Qi and Perera, {Nirma D} and Refsgaard, {Louise K} and Reid, {Kimberley M} and Mariam Sabbar and Arghyadip Sahoo and Natascha Schaefer and Sheean, {Rebecca K} and Anna Suska and Rajkumar Verma and Cinzia Vicidomini and Dean Wright and Xing-Ding Zhang and Constanze Seidenbecher",

note = "{\textcopyright} 2016 The Authors. Journal of Neurochemistry published by John Wiley & Sons Ltd on behalf of International Society for Neurochemistry.",

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doi = "10.1111/jnc.13713",

language = "English",

volume = "138",

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TY - JOUR

T1 - Synaptopathies

T2 - synaptic dysfunction in neurological disorders - A review from students to students

AU - Lepeta, Katarzyna

AU - Lourenco, Mychael V

AU - Schweitzer, Barbara C

AU - Martino Adami, Pamela V

AU - Banerjee, Priyanjalee

AU - Catuara-Solarz, Silvina

AU - de La Fuente Revenga, Mario

AU - Guillem, Alain Marc

AU - Haidar, Mouna

AU - Ijomone, Omamuyovwi M

AU - Nadorp, Bettina

AU - Qi, Lin

AU - Perera, Nirma D

AU - Refsgaard, Louise K

AU - Reid, Kimberley M

AU - Sabbar, Mariam

AU - Sahoo, Arghyadip

AU - Schaefer, Natascha

AU - Sheean, Rebecca K

AU - Suska, Anna

AU - Verma, Rajkumar

AU - Vicidomini, Cinzia

AU - Wright, Dean

AU - Zhang, Xing-Ding

AU - Seidenbecher, Constanze

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Abstract: Synapses are essential components of neurons and allow information to travel coordinately throughout the nervous system to adjust behavior to environmental stimuli and to control body functions, memories, and emotions. Thus, optimal synaptic communication is required for proper brain physiology, and slight perturbations of synapse function can lead to brain disorders. In fact, increasing evidence has demonstrated the relevance of synapse dysfunction as a major determinant of many neurological diseases. This notion has led to the concept of synaptopathies as brain diseases with synapse defects as shared pathogenic features. In this review, which was initiated at the 13th International Society for Neurochemistry Advanced School, we discuss basic concepts of synapse structure and function, and provide a critical view of how aberrant synapse physiology may contribute to neurodevelopmental disorders (autism, Down syndrome, startle disease, and epilepsy) as well as neurodegenerative disorders (Alzheimer and Parkinson disease). We finally discuss the appropriateness and potential implications of gathering synapse diseases under a single term. Understanding common causes and intrinsic differences in disease-associated synaptic dysfunction could offer novel clues toward synapse-based therapeutic intervention for neurological and neuropsychiatric disorders. (Figure presented.) In this Review, which was initiated at the 13th International Society for Neurochemistry (ISN) Advanced School, we discuss basic concepts of synapse structure and function, and provide a critical view of how aberrant synapse physiology may contribute to neurodevelopmental (autism, Down syndrome, startle disease, and epilepsy) as well as neurodegenerative disorders (Alzheimer's and Parkinson's diseases), gathered together under the term of synaptopathies. Read the Editorial Highlight for this article on page 783.

AB - Abstract: Synapses are essential components of neurons and allow information to travel coordinately throughout the nervous system to adjust behavior to environmental stimuli and to control body functions, memories, and emotions. Thus, optimal synaptic communication is required for proper brain physiology, and slight perturbations of synapse function can lead to brain disorders. In fact, increasing evidence has demonstrated the relevance of synapse dysfunction as a major determinant of many neurological diseases. This notion has led to the concept of synaptopathies as brain diseases with synapse defects as shared pathogenic features. In this review, which was initiated at the 13th International Society for Neurochemistry Advanced School, we discuss basic concepts of synapse structure and function, and provide a critical view of how aberrant synapse physiology may contribute to neurodevelopmental disorders (autism, Down syndrome, startle disease, and epilepsy) as well as neurodegenerative disorders (Alzheimer and Parkinson disease). We finally discuss the appropriateness and potential implications of gathering synapse diseases under a single term. Understanding common causes and intrinsic differences in disease-associated synaptic dysfunction could offer novel clues toward synapse-based therapeutic intervention for neurological and neuropsychiatric disorders. (Figure presented.) In this Review, which was initiated at the 13th International Society for Neurochemistry (ISN) Advanced School, we discuss basic concepts of synapse structure and function, and provide a critical view of how aberrant synapse physiology may contribute to neurodevelopmental (autism, Down syndrome, startle disease, and epilepsy) as well as neurodegenerative disorders (Alzheimer's and Parkinson's diseases), gathered together under the term of synaptopathies. Read the Editorial Highlight for this article on page 783.

KW - Journal Article

KW - Review

U2 - 10.1111/jnc.13713

DO - 10.1111/jnc.13713

M3 - Journal article

C2 - 27333343

SN - 0022-3042

VL - 138

SP - 785

EP - 805

JO - Journal of Neurochemistry

JF - Journal of Neurochemistry

IS - 6

ER -

Synaptopathies: synaptic dysfunction in neurological disorders - A review from students to students

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