Symptomatic therapy in multiple sclerosis: a review for a multimodal approach in clinical practice

João Carlos Correia de Sa; Laura Airas; Emmanuel Bartholome; Nikolaos Grigoriadis; Heinrich Mattle; Celia Oreja-Guevara; Jonathan O'Riordan; Finn Sellebjerg; Bruno Stankoff; Karl Vass; Agata Walczak; Heinz Wiendl; Bernd C Kieseier

doi:http://dx.doi.org/10.1177/1756285611403646

Symptomatic therapy in multiple sclerosis: a review for a multimodal approach in clinical practice

João Carlos Correia de Sa, Laura Airas, Emmanuel Bartholome, Nikolaos Grigoriadis, Heinrich Mattle, Celia Oreja-Guevara, Jonathan O'Riordan, Finn Sellebjerg, Bruno Stankoff, Karl Vass, Agata Walczak, Heinz Wiendl, Bernd C Kieseier

Department of Clinical Medicine

49 Citations (Scopus)

Abstract

As more investigations into factors affecting the quality of life of patients with multiple sclerosis (MS) are undertaken, it is becoming increasingly apparent that certain comorbidities and associated symptoms commonly found in these patients differ in incidence, pathophysiology and other factors compared with the general population. Many of these MS-related symptoms are frequently ignored in assessments of disease status and are often not considered to be associated with the disease. Research into how such comorbidities and symptoms can be diagnosed and treated within the MS population is lacking. This information gap adds further complexity to disease management and represents an unmet need in MS, particularly as early recognition and treatment of these conditions can improve patient outcomes. In this manuscript, we sought to review the literature on the comorbidities and symptoms of MS and to summarize the evidence for treatments that have been or may be used to alleviate them.

Original language	English
Journal	Therapeutic Advances in Neurological Disorders
Volume	4
Issue number	3
Pages (from-to)	139-68
Number of pages	30
ISSN	1756-2856
DOIs	https://doi.org/10.1177/1756285611403646
Publication status	Published - May 2011

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de Sa, J. C. C., Airas, L., Bartholome, E., Grigoriadis, N., Mattle, H., Oreja-Guevara, C., O'Riordan, J., Sellebjerg, F., Stankoff, B., Vass, K., Walczak, A., Wiendl, H., & Kieseier, B. C. (2011). Symptomatic therapy in multiple sclerosis: a review for a multimodal approach in clinical practice. Therapeutic Advances in Neurological Disorders, 4(3), 139-68. https://doi.org/10.1177/1756285611403646

de Sa, JCC, Airas, L, Bartholome, E, Grigoriadis, N, Mattle, H, Oreja-Guevara, C, O'Riordan, J, Sellebjerg, F, Stankoff, B, Vass, K, Walczak, A, Wiendl, H & Kieseier, BC 2011, 'Symptomatic therapy in multiple sclerosis: a review for a multimodal approach in clinical practice', Therapeutic Advances in Neurological Disorders, vol. 4, no. 3, pp. 139-68. https://doi.org/10.1177/1756285611403646

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abstract = "As more investigations into factors affecting the quality of life of patients with multiple sclerosis (MS) are undertaken, it is becoming increasingly apparent that certain comorbidities and associated symptoms commonly found in these patients differ in incidence, pathophysiology and other factors compared with the general population. Many of these MS-related symptoms are frequently ignored in assessments of disease status and are often not considered to be associated with the disease. Research into how such comorbidities and symptoms can be diagnosed and treated within the MS population is lacking. This information gap adds further complexity to disease management and represents an unmet need in MS, particularly as early recognition and treatment of these conditions can improve patient outcomes. In this manuscript, we sought to review the literature on the comorbidities and symptoms of MS and to summarize the evidence for treatments that have been or may be used to alleviate them.",

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AU - Mattle, Heinrich

AU - Oreja-Guevara, Celia

AU - O'Riordan, Jonathan

AU - Sellebjerg, Finn

AU - Stankoff, Bruno

AU - Vass, Karl

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AU - Wiendl, Heinz

AU - Kieseier, Bernd C

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AB - As more investigations into factors affecting the quality of life of patients with multiple sclerosis (MS) are undertaken, it is becoming increasingly apparent that certain comorbidities and associated symptoms commonly found in these patients differ in incidence, pathophysiology and other factors compared with the general population. Many of these MS-related symptoms are frequently ignored in assessments of disease status and are often not considered to be associated with the disease. Research into how such comorbidities and symptoms can be diagnosed and treated within the MS population is lacking. This information gap adds further complexity to disease management and represents an unmet need in MS, particularly as early recognition and treatment of these conditions can improve patient outcomes. In this manuscript, we sought to review the literature on the comorbidities and symptoms of MS and to summarize the evidence for treatments that have been or may be used to alleviate them.

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Symptomatic therapy in multiple sclerosis: a review for a multimodal approach in clinical practice

Abstract

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